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An Inhibitory Effects of Silsosangami on the Atherosclerosis in Hypercholesterolemic Rabbits
Shin, Sang Seub,Choi, Dall Yeong,Kim, Cherl Ho,Park, Soo Young,Kim, Chang Hwan,Kim, Jun Kee,Park, Sun Dong,Moon, Jin Young,Kim, Beub Jin,Park, Won Hwan 대한동의병리학회 2001 동의생리병리학회지 Vol.15 No.5
The traditinal korean therapeutic system has been used for the treatment of various disease, including the clinical treatment of hypercholesterolemia, diabetes and obesity. Hypercholesterolemia is considered to be a major cause of the lesions associated with atherosclerosis, and a number of hypercholesterolemic drugs are used to improve the plasma lipid level of patients. Silsosangami(SSG) has been reported to have a hypolipidemic effect in patients with hypercholesterolemia and in cholesterol-induced experimental models. The present paper reports the effect of extracts obtained from SSG on heperlipemia and normal rabbits. The inhibitory effects of the traditional herbal medicine SSG on the progression of the atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model , Kurosawa and Kusanagi-hypercholesterolemic(KHC) rabbits. Changes in blood chemistry, pathology and low-density lipoprotein(LDL) oxidation were measured in a control group and a SSG group. In the control group, the area of atheromatous plaques of the aorta progressed between 4 weeks (30.43%) and 8 weeks (47.48%). This progressin of atherosclerotic lesions did not happen in the SSG-treated group between 4 weeks (22.65%) and 8 weeks (23.23%). Antioxidative effects on LDL were seen in the SSG in weeks 12 and 14. SSG improved the hypercholestrolemia in the KHC rabbits. These results suggest that SSG has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH model rabbits.