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Berber, Ufuk,Yilmaz, Ismail,Yilmaz, Omer,Haholu, Aptullah,Kucukodaci, Zafer,Ates, Ferhat,Demirel, Dilaver Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
We aimed to investigate bladder cancer risk with reference to polymorphic variants of cytochrome p450 (CYP) 1A1, CYP1B1, glutathione S-transferase (GST) M1, and GSTT1 genes in a case control study. Polymorphisms were examined in 114 bladder cancer patients and 114 age and sex-matched cancer-free subjects. Genotypes were determined using allele specific PCR for CYP1A1 and CYP1B1 genes, and by multiplex PCR and melting curve analysis for GSTM1 and GSTT1 genes. Our results revealed a statistically significant increased bladder cancer risk for GSTT1 null genotype carriers with an odds ratio of 3.06 (95% confidence interval=1.39-6.74, p=0.006). Differences of CYP1A1, CYP1B1 and GSTM1 genotype frequencies were not statistically significant between patients and controls. However, the specific combination of GSTM1 null, GSTT1 null, and CYP1B1 codon 119 risk allele carriers and specific combination of GSTM1 present, GSTT1 null, and CYP1B1 432 risk allele carriers exhibited increased cancer risk in the combined analysis. We did not observe any association between different genotype groups and prognostic tumor characteristics of bladder cancer. Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.
Ufuk Berber,Ismail Yilmaz,Gizem Narli,Aptullah Haholu,Zafer Kucukodaci,Dilaver Demirel 한국유방암학회 2014 Journal of breast cancer Vol.17 No.2
Purpose: We examined expression profiles of 16 micro RNAs(miRNAs) in triple negative breast cancers to identify their potentialas biomarkers for lymph node metastasis. Methods: The expressionprofiles of miR-9, miR-21, miR-30a, miR-30d, miR-31,miR-34a, miR-34c, miR-100, miR-122, miR-125b, miR-146a,miR-146b, miR-155, miR-181a, miR-200c, and miR-205 wereexamined by using real-time quantitative reverse transcriptionpolymerase chain reaction in tumor samples and correspondingbenign breast tissues. Their associations with histopathologicalfeatures and prognostic parameters were assessed. Results:When compared with the expression in benign breast tissues,seven of the miRNAs (miR-31, miR-205, miR-34a, miR-146a,miR-125b, miR-34c, and miR-181a) were downregulated morethan 1.5-fold in tumor tissues, whereas, only miR-21 was foundto be upregulated more than 1.5-fold in tumor tissues. AlthoughmiR-200c levels were decreased only 1.12-fold in tumor tissues,the reduced expressions of miR-200c and miR-205 were significantlyassociated with lymph node metastasis (p=0.021 and p=0.016, respectively). Conclusion: Our results demonstrate thatmiR-205 and miR-200c expression levels may be useful in predictinglymph node metastasis in triple negative breast cancerpatients.
Tanoglu, Alpaslan,Balta, Ahmet Ziya,Berber, Ufuk,Ozdemir, Yavuz,Emirzeoglu, Levent,Sayilir, Abdurrahim,Sucullu, Ilker Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: There are increasing data about microRNAs (miRNA) in the literature, providing abundant evidence that they play important roles in pathogenesis and development of colorectal cancer. In this study, we aimed to investigate the miRNA expression profiles in surgically resected specimens of patients with recurrent and non-recurrent colorectal cancer. Materials and Methods: The study population included 40 patients with stage II colorectal cancer (20 patients with recurrent tumors, and 20 sex and age matched patients without recurrence), who underwent curative colectomy between 2004 and 2011 without adjuvant therapy. Expression of 16 miRNAs (miRNA-9, 21, 30d, 31, 106a, 127, 133a, 133b, 135b, 143, 145, 155, 182, 200a, 200c, 362) was verified by quantitative real-time polymerase chain reaction (qRT-PCR) in all resected colon cancer tissue samples and in corresponding normal colonic tissues. Data analyses were carried out using SPSS 15 software. Values were statistically significantly changed in 40 cancer tissues when compared to the corresponding 40 normal colonic tissues (p<0.001). MiR-30d, miR-133a, miR-143, miR-145 and miR-362 expression was statistically significantly downregulated in 40 resected colorectal cancer tissue samples (p<0.001). When we compared subgroups, miRNA expression profiles of 20 recurrent cancer tissues were similar to all 40 cancer tissues. However in 20 non-recurrent cancer tissues, miR-133a expression was not significantly downregulated, moreover miR-133b expression was significantly upregulated (p<0.05). Conclusions: Our study revealed dysregulation of expression of ten miRNAs in Turkish colon cancer patients. These miRNAs may be used as potential biomarkers for early detection, screening and surveillance of colorectal cancer, with functional effects on tumor cell behavior.
The electrical properties of ZnO/Si heterojunction diode depending on thin film thickness
Akın Ümmühan,Houimi Amina,Gezgin Bahri,Gündoğdu Yasemin,Kılıç Sümeyye,Mercimek Bedrettin,Berber Adnan,Gezgin Serap Yiğit 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.2
In this work, ZnO thin flms have been produced on p-Si wafer depending on number of laser pulses applied using pulse laser deposition (PLD) technique at room temperature conditions. Three diferent thicknesses of ZnO thin flms (ZnO1, ZnO2 and ZnO3) have been produced by applying 18,000, 36,000 and 54,000 laser pulses and thicknesses of these produced three thin flms have been measured to be 41 nm, 70 nm, 197 nm, respectively. It is observed in this work that while thicknesses of ZnO thin flms increases, crystal structure of thin flms develops, their grain size increase while their band gaps decrease. Ag/ZnO/ Si/Au heterojunction diodes have been produced based on ZnO1, ZnO2 and ZnO3 thin flms. After that, efect of thickness of thin flm on electrical properties of diodes produced depending on number of laser pulses has been analyzed in detail. I–V characteristics of ZnO/Si heterojunction diodes produced have also been measured in darkness environment and under illumination conditions (AM 1.5 solar radiation of 80 mW/cm2 ) and results obtained have been interpreted and a conclusion has been made in this work. Furthermore, ideality factors, barrier heights and serial resistivities of these diodes have been calculated using conventional thermionic emission theory, Norde and Cheung-Cheung methods and then results obtained from analytical methods have been interpreted in detail in the present article. ZnO heterojunction diodes have exhibited photovoltaic properties under illumination conditions. It has been observed that as thickness of ZnO thin flm is increased, Jsc and η values of the hetero junction diodes are increased. ZnO-3A hetero junction diode has exhibited the most improved photovoltaic performance. We have also theoretically investigated photo-electric properties of ZnO-3A heterojunction diode using SCAPS-1D packed software. The resulted J–V characteristics have been found very similar to measured counterparts.