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BENTHIC AMPHIPOD FAUNA (CRUSTACEA) OF THE PORTUGUESE COAST: BIOGEOGRAPHICAL CONSIDERATIONS
Bellan-Santini,Denise,Marques,Joao Carlos 嶺南大 海洋科學硏究所 1990 Marine Nature Vol.3 No.1
Biogeographic affinities of the Amphipod fauna from the Portuguese Coast were analysed. The Portuguese Coast appeared as a transition zone where faunas from the Mediterranean and of northern affinities become mixed. The biogeographic affinities between the Portuguese Coast and the Mauritanian and Senegalese regions still remained difficult to interpret. The comparison of the life cycles between several populations of Echinogammarus marinus (Leach), under different environmental constraints, showed that Gammarids can have large intraspecific variations in their reproductive patterns, which might have an important role in marine amphipods speciation.
Mattia Bellan,Cosimo Colletta,Matteo Nazzareno Barbaglia,Livia Salmi,Roberto Clerici,Venkata Ramana Mallela,Luigi Mario Castello,Giuseppe Saglietti,Gian Piero Carnevale Schianca,Rosalba Minisini,Mario 대한당뇨병학회 2019 Diabetes and Metabolism Journal Vol.43 No.5
Background: The prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with type 2 diabetes mellitus (T2DM) ishigh, though its severity is often underestimated. Our aim is to provide an estimate of the prevalence of severe NAFLD in T2DMand identify its major predictors. Methods: T2DM patients (n=328) not previously known to have NAFLD underwent clinical assessment, transient elastographywith measure of liver stiffness (LS) and controlled attenuation parameter (CAP), and genotyping for patatin like phospholipasedomain containing 3 (PNPLA3) and 17β-hydroxysteroid-dehydrogenase type 13 (HSD17B13). Results: Median LS was 6.1 kPa (4.9 to 8.6). More than one-fourth patients had advanced liver disease, defined as LS ≥7.9 kPa(n=94/238, 29%), and had a higher body mass index (BMI) than those with a LS <7.9 kPa. Carriage of the G allele in the PNPLA3gene was associated with higher LS, being 5.9 kPa (4.7 to 7.7) in C/C homozygotes, 6.1 kPa (5.2 to 8.7) in C/G heterozygotes, and6.8 kPa (5.8 to 9.2) in G/G homozygotes (P=0.01). This trend was absent in patients with ≥1 mutated HSD17B13 allele. In a multiplelinear regression model, BMI and PNPLA3 genotype predicted LS, while age, gender, disease duration, and glycosylated hemoglobindid not fit into the model. None of these variables was confirmed to be predictive among carriers of at least one HSD17B13mutated allele. There was no association between CAP and polymorphisms of PNPLA3 or HSD17B13. Conclusion: Advanced NAFLD is common among T2DM patients. LS is predicted by both BMI and PNPLA3 polymorphism,the effect of the latter being modulated by mutated HSD17B13.
Marshall, Ryan S.,Chai, Kil-Byoung,Bellan, Paul M. American Astronomical Society 2017 The Astrophysical Journal Vol.837 No.1
<P>The grain growth process in the Caltech water-ice dusty plasma experiment has been studied using a high-speed camera and a long-distance microscope lens. It is observed that (i) the ice grain number density decreases fourfold as the average grain major axis increases from 20 to 80 mu m, (ii) the major axis length has a log-normal distribution rather than a power-law dependence, and (iii) no collisions between ice grains are apparent. The grains have a large negative charge resulting in strong mutual repulsion and this, combined with the fractal character of the ice grains, prevents them from agglomerating. In order for the grain kinetic energy to be sufficiently small to prevent collisions between ice grains, the volumetric packing factor (i.e., ratio of the actual volume to the volume of a circumscribing ellipsoid) of the ice grains must be less than similar to 0.1 depending on the exact relative velocity of the grains in question. Thus, it is concluded that direct accretion of water molecules is very likely to dominate the observed ice grain growth.</P>
Nasal septum angiofibroma: a rare condition with an unusual onset
Maria Carla Spinosi,Francesca D’Amico,Chiara Mezzedimi,Cristiana Bellan,Manuela Cirami,Ilaria Innocenti Paganelli 대한구강악안면외과학회 2019 대한구강악안면외과학회지 Vol.45 No.1
The characteristics of extra-nasopharyngeal angiofibromas tend to be different from angiofibromas of the nasopharynx according to patient gender, patient age, prevalence, affected site, pathogenesis, and clinical and epidemiological features. We report a case of an extra-nasopharyngeal angiofibroma in a 28-year-old man referred to the ENT Clinic for right-sided epistaxis, airflow impairment and nasal swelling. The right nostril was completely occluded works by a reddish-yellow mass that bled easily. The computed tomography scan revealed an “inhomogeneous solid lesion in the nasal fossa”. With the patient under general anesthesia, the formation in the anterior portion of the right side of the nasal septum was removed up to its vascular base. Although electrical cauterization efficiently controlled the bleeding, we abraded the sub-perichondral area to prevent further bleeding as well as recurrence. The histological exam report confirmed the diagnosis of angiofibroma. As in our case, epistaxis is commonly the presenting sign of angiofibroma. Yet its onset was peculiar, given that the bleeding started with a low impact trauma. The nasal swelling was also a relevant feature as well as the breathing impairment. Although uncommon, nasal septal angiofibromas should considered in patients with epistaxis.
Margherita Baldassarri,Chiara Fallerini,Francesco Cetta,Marco Ghisalberti,Cristiana Bellan,Simone Furini,Ottavia Spiga,Sergio Crispino,Giuseppe Gotti,Francesca Ariani,Piero Paladini,Alessandra Renieri 대한암학회 2018 Cancer Research and Treatment Vol.50 No.2
Purpose Lung cancer is strongly associated to tobacco smoking. However, global statistics estimate that in females the proportion of lung cancer cases that is unrelated to tobacco smoking reaches fifty percent, making questionable the etiology of the disease. Materials and Methods A never-smoker female with primary EGFR/KRAS/ALK-negative squamous cell carcinoma of the lung and their normal sibs were subjected to a novel integrative “omic” approach using a pedigree-based model for discovering genetic factors leading to cancer in the absence of well-known environmental trigger. A first-step whole-exome sequencing on tumor and normal tissue did not identify mutations in known driver genes. Building on the idea of a germline oligogenic origin of lung cancer, we performed whole-exome sequencing of DNA from patients’ peripheral blood and their unaffected sibs. Finally, RNA-sequencing analysis in tumoral and matched non-tumoral tissues was carried out in order to investigate the clonal profile and the pathogenic role of the identified variants. Results Filtering for rare variants with Combined Annotation Dependent Depletion (CADD) > 25 and potentially damaging effect, we identified rare/private germline deleterious variants in 11 cancer-associated genes, none of which, except one, shared with the healthy sib, pinpointing to a “private” oligogenic germline signature. Noteworthy, among these, two mutated genes, namely ACACA and DEPTOR, turned to be potential targets for therapy because related to known drivers, such as BRCA1 and EGFR. Conclusion In the era of precision medicine, this report emphasizes the importance of an “omic” approach to uncover oligogenic germline signature underlying cancer development and to identify suitable therapeutic targets as well.