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- 저자 : Bei-bei Duan (검색결과 3 건)
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Gang Wang,Peng-yu Duan,Yuan Ma,Xi-na Li,Feng-zhi Qu,Liang Ji,Xiao-yu Guo,Wang-jun Zhang,Fan Xiao,Le Li,Ji-sheng Hu,Bei Sun 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Currently, preliminary results have confirmed the existence of receptor-interacting protein kinase 3 (RIPK3) and mixed lineage kinase domain-like protein (MLKL)-dependent necroptosis of pancreatic acinar cells during early acute pancreatitis (AP), which might be a potential target for the effective regulation of necroinflammatory injury. However, the exact effect of receptor-interacting protein kinase 1 (RIPK1)-dependent regulated acinar cell necrosis on AP is still uncertain. In our study, we first explored the changes in the degree of local and systemic inflammation in AP rats when the activation of acinar cell RIPK1 was inhibited. The RIPK1 inhibitor Nec-1 was used to treat rats, and the levels of related inflammatory markers, necrosis indicators and apoptotic indicators were measured. Changes in pancreatic nuclear factor κB (NF-κB) and aquaporin 8 (AQP8) expression were noted. Next, the expression of AQP8 in AR42J cells was inhibited, and the degree of cell necrosis and inflammatory damage was found to be significantly reduced. Most importantly, we demonstrated that the RIPK1/NF-ĸB/AQP8 axis might be a potential regulatory pathway mediating RIPK1-dependent regulated acinar cell necrosis in early AP. Finally, we used the NF-κB inhibitor PDTC and Nec-1 to treat rats in different groups and measured the degree of pathological pancreatic injury, the activation of RIPK1, and the expression of NF-κB and AQP8. In summary, we hypothesized that there might be a RIPK1/NF-ĸB/AQP8 pathway controlling RIPK1-dependent regulated necrosis of acinar cells in AP, which might be a promising therapeutic target against AP-related injury.
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Xiang-li Long,Bei-bei Duan,Hai-xia Cao,Ming-lei Jia,Long-an Wu 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.62 No.-
The simultaneous scrubbing of NO and SO2 can be finished with the Co(NH3)62+ ammonia solution. Activated carbon aids the regeneration of Co(NH3)62+ to retain the ability of absorbing NO. Acetic acid is tried to improve the catalytic capability of activated carbon. The best treatment condition is the carbon samples impregnated in 2.0 mol l−1 HAc solution for 20 h followed by being calcined at 600 °C for 4 h. The HAc modification increases surface area and acidic groups on the carbon surface. The experiments prove that the modified carbon can obtain a higher NO removal efficiency than the original carbon.
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Study of Delay-Independent Decentralized Guaranteed Cost Control for Large Scale Systems
Chun-Xia Dou,Zhi-Sheng Duan,Xing-Bei Jia,Pei-Feng Niu 제어·로봇·시스템학회 2011 International Journal of Control, Automation, and Vol.9 No.3
This study introduces delay independent decentralized guaranteed cost control design method based on two controller structures for nonlinear uncertain interconnected large scale systems with time delays. First, a set of equivalent Takagi-Sugeno (T-S) fuzzy models are extended to represent the systems. Then a decentralized state-feedback guaranteed cost performance controller is proposed for the fuzzy systems. Based on delay independent Lyapunov functional approach, some sufficient conditions for the existence of the controller can be cast into the feasible problem of LMIs irrespective of the sizes of the time delays so that the system can be asymptotically stabilized for all considered uncertainties whose sizes are not larger than their bounds. Finally, the minimizing approach is proposed to search the suboptimal upper bound value of guaranteed cost function. Moreover, the corresponding conditions are extended into the generalized dynamic output-feedback close-loop system. Finally, the better control performances of the proposed methods are shown by the simulation examples.
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