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      • Analysis of High-Enriched Core Composition Behavior in Micro Modular Reactor During Long-Cycle Operation

        Kiho Park,Minhyeok Bang,Gyutaek Kang 한국방사성폐기물학회 2023 한국방사성폐기물학회 학술논문요약집 Vol.21 No.2

        Recently, as carbon-neutral energy sources become increasingly important worldwide, SMRs (Small Modular Reactors), which offer significantly enhanced safety, versatility, and mobility compared to conventional nuclear reactors, are gaining attention as a viable alternative. SMR generally refers to small modular reactors with a power output of 300 MWe or less. Unlike conventional reactors, SMRs are characterized by an all-in-one design where peripheral systems and equipment are all integrated into the reactor itself, leading to enhanced reliability and durability. Additionally, the nuclear fuel reloading cycle is significantly extended compared to traditional reactors, resulting in a substantial reduction in maintenance difficulty and costs. Researchers have taken note of these characteristics of SMRs, particularly the extended fuel reloading cycle. Therefore, we have initiated the initial design of an ultra-small Micro Modular Reactor with an electricity generation capacity of 10 MWe and a fuel cycle of up to 55 years, with the goal of using it as a propulsion power source for various transportation modes, especially ships. Our design of MMR, called ‘ARA,’ is primarily distinguished by its use of U233 and Th232 fuels instead of conventional UO2 fuel. Due to various features of ‘ARA,’ including different fuel compositions, ARA is predicted to exhibit several characteristic features compared to conventional PWRs. In this study, among these characteristics, we focused on predicting changes in material composition within the fuel rod during the extended cycle operation of high-enriched fuel, rather than short-cycle operation using low-enriched fuel, unlike conventional reactors. The primary goal of this research is to observe the behavior of the composition of the materials used in the fuel cycle of the MMR, which utilizes U233 and Th232 fuels instead of UO2. Considering the difficulties in the spent nuclear fuel disposal process, many different trials were made to minimize the fission products of ARA, which differs from conventional reactors in terms of fuel type, size, and fuel cycle, in relation to waste generation.

      • KCI등재

        지표지형효과에 따른 지진지반운동 증폭에 대한 실용적 고찰

        선창국,방기호,조완제,Sun. Chang-Guk,Bang. Kiho,Cho. Wanjei 한국방재학회 2012 한국방재학회논문집 Vol.12 No.3

        지질지반 조건의 공간적 분포와 관련된 부지효과는 지진 시 지반운동의 증폭에 지대한 영향을 미친다. 즉, 지표부근 지질지반의 층상구조와 물성뿐만 아니라 지표면 지형 및 분지 형상이 부지효과의 영향 요인이다. 이러한 부지효과 관련 영향 요소들 중에서 단지 지표부근 지질지반 조건에 따른 증폭 정도만이 미국 서부지역 기준을 근간으로 하는 국내 현행 내진설계 지침에 반영되어 있다. 그럼에도 불구하고, 최근까지의 전 세계 지진 발생 사례들로부터 지표지형 변화에 따른 광범위하고 심각한 피해들을 확인해 볼 수 있다. 이러한 사례들의 구체적인 현상들을 이 연구에서 고찰 제시하였다. 또한, 지형효과의 정량화 기법을 파악하기 위하여 주요 내진설계 기준들을 검토하였다. 이러한 고찰 검토 내용들을 토대로, 국내 내진설계를 위한 지형효과 결정기법에 대해 예비적 토의를 진행하고 일차원과 이차원 수치 모델 해석 결과 비교를 통해 각각의 변수가 지형효과에 미치는 영향을 파악하는 것을 기존 기준들의 도입 개선과 함께 그 방안으로 제시하였다. Site effects associated with the spatial distribution of geologic and soil conditions have a significant influence on the amplification of ground motions during an earthquake. Exactly, the stratification structure and physical properties of near-surface soils and geology, as well as the surface topography and basin geometry, affect the site effects. Among these several influence factors on the site effects, only the amplification capabilities depending on the near-surface geologic conditions have been incorporated into current Korean seismic design guidelines, which is based on the codes in the western United States. Nonetheless, extensive severe damages caused by the irregularities in surface topography have been observed from the past and recent earthquake events over the world, and their detailed phenomena were investigated in this study. Several important seismic design codes were also reviewed to examine the methodologies for quantifying the topographic effects. Consequently, the methodology to determine the topographic effect in seismic design of Korea was discussed preliminarily and suggested as the quantitative comparisons between one- and two-dimensional numerical models, together with the introduction and modification of current other codes.

      • KCI등재

        Development of PCR based approach to detect potential mosaicism in porcine embryos

        Jongki Cho,Kyungjun Uh,Junghyun Ryu,Xun Fang,Seonggyu Bang,Kiho Lee 한국동물생명공학회(구 한국동물번식학회) 2020 Journal of Animal Reproduction and Biotechnology Vol.35 No.4

        Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs. The approach allows us to produce pigs carrying targeted modifications at high efficiency without having to apply somatic cell nuclear transfer. However, the targeted modifications during embryogenesis often result in mosaicism, which causes issues in phenotyping founder animals and establishing a group of pigs carrying intended modifications. This study was aimed to establish a genomic PCR and sequencing system of a single blastomere in the four-cell embryos to detect potential mosaicism. We performed genomic PCR in four individual blastomeres from four-cell embryos. We successfully amplified target genomic region from single blastomeres of 4-cell stage embryo by PCR. Sanger sequencing of the PCR amplicons obtained from the blastomeres suggested that PCR-based genotyping of single blastomere was a feasible method to determine mutation type generated by genome editing technology such as CRISPR/Cas9 in early stage embryos. In conclusion, we successfully genotyped single blastomeres in a single 4-cell stage embryo to detect potential mosaicism in porcine embryos. Our approach offers a simple platform that can be used to screen the prevalence of mosaicism from designed CRISPR/Cas9 systems.

      • KCI등재

        Development of PCR based approach to detect potential mosaicism in porcine embryos

        Cho, Jongki,Uh, Kyungjun,Ryu, Junghyun,Fang, Xun,Bang, Seonggyu,Lee, Kiho The Korean Society of Animal Reproduction and Biot 2020 한국동물생명공학회지 Vol.35 No.4

        Direct injection of genome editing tools such as CRISPR/Cas9 system into developing embryos has been widely used to generate genetically engineered pigs. The approach allows us to produce pigs carrying targeted modifications at high efficiency without having to apply somatic cell nuclear transfer. However, the targeted modifications during embryogenesis often result in mosaicism, which causes issues in phenotyping founder animals and establishing a group of pigs carrying intended modifications. This study was aimed to establish a genomic PCR and sequencing system of a single blastomere in the four-cell embryos to detect potential mosaicism. We performed genomic PCR in four individual blastomeres from four-cell embryos. We successfully amplified target genomic region from single blastomeres of 4-cell stage embryo by PCR. Sanger sequencing of the PCR amplicons obtained from the blastomeres suggested that PCR-based genotyping of single blastomere was a feasible method to determine mutation type generated by genome editing technology such as CRISPR/Cas9 in early stage embryos. In conclusion, we successfully genotyped single blastomeres in a single 4-cell stage embryo to detect potential mosaicism in porcine embryos. Our approach offers a simple platform that can be used to screen the prevalence of mosaicism from designed CRISPR/Cas9 systems.

      • 중풍 발생 위험인자에 대한 환자-대조군 연구

        강경원(Kang Kyungwon),강병갑(Kang Byunggab),차민호(Cga Minho),고미미(Go Mimi),박세욱(Park Saewook),방옥선(Bang Oaksun),조기호(Cho Kiho),김윤식(Kim Yoonsik),최선미(Sunmi Choi) 한국한의학연구원 2007 한국한의학연구원논문집 Vol.13 No.2

        Background and Purpose : The purpose of this case-control study was to show the relationship between risk factors(past medical history, BMI, WHR, smoking, drinking), warning signs(dyscinesia, sightless, dysarthria, sensory disorder, numbness, blephalospasm, facial spasm, tension) and the incidence of stroke in korean adults. Methods : 455 stroke patients were enrolled as the case group and 180 non-stroke patients as control group from Oct. 2005 to Feb. 2006. Patients were hospitalized within 2 weeks after the onset of stroke. Obesity were defined as BMI≥25㎏/m2, WHR≥0.9 in male and WHR≥0.8 in female. Risk factors and warning signs were obtained from personal interview. The analysis of the data was done by chi-square test, Fisher's exact test and two-sample t-test. Results : The percentage of current smokers(or current drinkers) of case group is higher significantly than that of control group. The past medical history of risk factors were found to be transient ischemic attack(p=0.0698), facial palsy(p=0.406l), hypertension(p<0.0001), hyperlipidemia(p=0.l484), DM(p<0.0001), ischemic heart disease(p=0.0093). migraine(p=0.0014) and hypochondria(p=0.2370). WHR≥0.9 in male had a 6.696 (3.711-12.082) odds ratio, WHR≥0.8 in female had a 1.567 (0.659-3.726) odds ratio. BMI≥25㎏/m2 had a 2.017(1.263-3.222). The dyscinesia and sensory disorder of warning signs were found to be statistical difference between case and control group. Conclusions : According to the above results, it was found that smoking, drinking, BMI, WHR, hypertension, DM, ischemic heart disease, migraine affected to the incidence of stroke.

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