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Three “DS” - Elements for Successful Weight Loss Outcomes: Role of Healthcare Professionals
( Dror Dicker ),( Assim A Alfadda ),( Pernille Auerbach ),( Ian D Caterson ),( Ada Cuevas ),( Jason Halford ),( Masato Iwabu ),( Jae-Heon Kang ),( Rita Nawar ),( Ricardo Arturo Reynoso Mendoza ),( Nic 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: In people with obesity (PwO), body weight loss of ≥5% is generally considered to be clinically meaningful. Some PwO do receive treatment and guidance from healthcare professionals (HCPs), but there remains a substantial unmet medical outcomes and weight maintenance need. To identify aspects that might contribute to a successful weight loss outcome (WLO; ≥5% body weight loss maintained for ≥1 year), we investigated the characteristics and experience of PwO with and without successful WLOs using data from the ACTION-IO study (NCT03584191). Methods: An online survey was completed by adults with obesity and HCPs in 11 countries: Australia, Chile, Israel, Italy, Japan, Mexico, Saudi Arabia, South Korea, Spain, UAE and UK. A successful WLO was defined as ≥5% body weight loss in the past 3 years maintained for ≥1 year. Results: A total of 14,502 PwO completed the survey. General characteristics were similar between those who had a successful WLO (n=1,559; 11%) vs those who had not (n=12,943; 89%): 53% vs 52% were male; the mean age was 49 vs 48 years; the mean number of comorbidities was 2.0 vs 1.8. The mean number of serious weight loss attempts was 4 for both groups. However, more PwO who had a successful WLO weighed themselves every day (20%) compared with those who had not had a successful WLO (10%). In terms of interactions with HCPs, more PwO who had a successful WLO had discussed weight (58%) with an HCP within the past 5 years than those who did not have a successful WLO (53%). In addition, more PwO who had a successful WLO compared with those who did not had been diagnosed with obesity (42% vs 35%) and had subsequent direction through the scheduling of a follow-up appointment (25% vs 21%). Conclusions: A 3D approach from HCPs (diagnosis, discussion and direction) appears to be a key element in facilitating a successful WLO. Neither gender, nor age, nor number of weight loss attempts was associated with a successful WLO.
Occult Gastric Cancer Presenting as Hypoxia from Pulmonary Tumor Thrombotic Microangiopathy
Mandaliya, Rohan,Farhat, Salman,Uprety, Dipesh,Balla, Mamtha,Gandhi, Apurva,Goldhahn, Richard,Auerbach, Herbert,Christensen, Chris,Reed, Conrad,Cohen, Sidney The Korean Gastric Cancer Association 2014 Journal of gastric cancer Vol.14 No.2
Pulmonary tumor thrombotic microangiopathy (PTTM) causing fatal pulmonary hypertension is a rare presentation of malignancy. In general, patients with PTTM rapidly succumb to death due to severe hypoxia. To date, very few cases of PTTM have been reported in the literature; and most of these cases were from gastric cancer and were diagnosed on post mortem autopsy, as it is extremely challenging to make an ante mortem diagnosis. We here report on a case of undiagnosed diffuse gastric cancer, presenting as worsening hypoxia. The clinical, radiographic, and echocardiographic features, and laboratory and pathological results were consistent with PTTM from gastric cancer. The patient was started on anticoagulation therapy, corticosteroids, and high-flow oxygen. However, her hypoxia worsened to the extent that she required ventilator support, and she died soon after intubation due to cardiac arrest. Since diffuse gastric cancer is associated with hereditary diffuse gastric cancer syndrome, cadherin 1 gene mutation analysis was performed to estimate the risk to her daughters. The test came back negative.
Occult gastric cancer presenting as hypoxia from pulmonary tumor thrombotic microangiopathy
Rohan Mandaliya,Salman Farhat,Dipesh Uprety,Mamtha Balla,Apurva Gandhi,Richard Goldhahn,Herbert Auerbach,Chris Christensen,Conrad Reed,Sidney Cohen 대한위암학회 2014 Journal of gastric cancer Vol.14 No.2
Pulmonary tumor thrombotic microangiopathy (PTTM) causing fatal pulmonary hypertension is a rare presentation of malignancy. In general, patients with PTTM rapidly succumb to death due to severe hypoxia. To date, very few cases of PTTM have been reported in the literature; and most of these cases were from gastric cancer and were diagnosed on post mortem autopsy, as it is extremely challenging to make an ante mortem diagnosis. We here report on a case of undiagnosed diffuse gastric cancer, presenting as worsening hypoxia. The clinical, radiographic, and echocardiographic features, and laboratory and pathological results were consistent with PTTM from gastric cancer. The patient was started on anticoagulation therapy, corticosteroids, and high-flow oxygen. However, her hypoxia worsened to the extent that she required ventilator support, and she died soon after intubation due to cardiac arrest. Since diffuse gastric cancer is associated with hereditary diffuse gastric cancer syndrome, cadherin 1 gene mutation analysis was performed to estimate the risk to her daughters. The test came back negative.
Measurement of theZZproduction cross section using the full CDF II data set
Aaltonen, T.,Amerio, S.,Amidei, D.,Anastassov, A.,Annovi, A.,Antos, J.,Apollinari, G.,Appel, J. A.,Arisawa, T.,Artikov, A.,Asaadi, J.,Ashmanskas, W.,Auerbach, B.,Aurisano, A.,Azfar, F.,Badgett, W.,Bae American Physical Society 2014 PHYSICAL REVIEW D - Vol.89 No.11
We present a measurement of the ZZ-boson pair-production cross section in 1.96 TeV center-of-mass energy p (p) over bar collisions. We reconstruct final states incorporating four charged leptons or two charged leptons and two neutrinos from the full data set collected by the Collider Detector experiment at the Fermilab Tevatron, corresponding to 9.7 fb(-1) of integrated luminosity. Combining the results obtained from each final state, we measure a cross section of 1.04(-0.25)(+0.32) pb, in good agreement with the standard model prediction at next-to-leading order in the strong-interaction coupling.
Measurement of central exclusiveπ+π−production inpp¯collisions ats=0.9and 1.96 TeV at CDF
Aaltonen, T.,Albrow, M. G.,Amerio, S.,Amidei, D.,Anastassov, A.,Annovi, A.,Antos, J.,Apollinari, G.,Appel, J. A.,Arisawa, T.,Artikov, A.,Asaadi, J.,Ashmanskas, W.,Auerbach, B.,Aurisano, A.,Azfar, F.,B American Physical Society 2015 PHYSICAL REVIEW D - Vol.91 No.9
Aaltonen, T.,Amerio, S.,Amidei, D.,Anastassov, A.,Annovi, A.,Antos, J.,Apollinari, G.,Appel, J. A.,Arisawa, T.,Artikov, A.,Asaadi, J.,Ashmanskas, W.,Auerbach, B.,Aurisano, A.,Azfar, F.,Badgett, W.,Bae American Physical Society 2014 PHYSICAL REVIEW D - Vol.89 No.7
<P>Drell-Yan lepton pairs are produced in the process p (p) over bar -> mu(+)mu(-) + X through an intermediate gamma*/Zboson. The forward-backward asymmetry in the polar-angle distribution of the mu(-) as a function of the invariant mass of the mu(+)mu(-) pair is used to obtain the effective leptonic determination sin(2)theta(lept)(eff) of the electroweakmixing parameter sin(2)theta w, from which the value of sin(2)theta w is derived assuming the standard model. The measurement sample, recorded by the Collider Detector at Fermilab (CDF), corresponds to 9.2 fb(-1) of integrated luminosity from p (p) over bar collisions at a center-of-momentum energy of 1.96 TeV, and is the full CDF Run II data set. The value of sin(2)theta(lept)(eff) is found to be 0.2315 +/- 0.0010, where statistical and systematic uncertainties are combined in quadrature. When interpreted within the context of the standard model using the on-shell renormalization scheme, where sin(2)theta w = 1 - M-W(2)/M-Z(2), the measurement yields sin(2)theta w = 0.2233 +/- 0.0009, or equivalently a W-boson mass of 80.365 +/- 0.047 GeV/c(2). The value of the W-boson mass is in agreement with previous determinations in electron- positron collisions and at the Tevatron collider.</P>
Mass and lifetime measurements of bottom and charm baryons inpp¯collisions ats=1.96 TeV
Aaltonen, T.,Amerio, S.,Amidei, D.,Anastassov, A.,Annovi, A.,Antos, J.,Apollinari, G.,Appel, J. A.,Arisawa, T.,Artikov, A.,Asaadi, J.,Ashmanskas, W.,Auerbach, B.,Aurisano, A.,Azfar, F.,Badgett, W.,Bae American Physical Society 2014 PHYSICAL REVIEW D - Vol.89 No.7