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- 저자 : Ashok Thorat (검색결과 3 건)
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Ashok Thorat,Long-Bin Jeng,Horng-Ren Yang,Chun-Chieh Yeh,Shih-Chao Hsu,Te-Hung Chen,Kin-Shing Poon 한국간담췌외과학회 2017 Annals of hepato-biliary-pancreatic surgery Vol.21 No.4
Backgrounds/Aims: The protective effect of everolimus (EVR) in hepatocellular carcinoma (HCC) patients who receive liver transplantation in terms of reducing the recurrence has not been sufficiently investigated in clinical trials. In this second stage of our ongoing study, we intend to analyze the effects of EVR as an immunosuppressant, when it is started in the early phase after living donor liver transplantation (LDLT), on HCC recurrence in patients with HCC within the University of California at San Francisco (UCSF) criteria. Methods: From January 2011 to June 2013, a total of 250 patients underwent LDLT for HCC at our institute. The patients with HCC within the UCSF criteria were included in the study and divided in two groups depending upon the postoperative immunosuppression. Group A: HCC patients that received EVR+TAC based immunosuppressive regimen (n=37). Group B: HCC patients that received standard TAC based immunosuppressive regimen without EVR (n=29). The target trough level for EVR was 3 to 5 ng/ml while for TAC it was 8-10 ng/ml. Results: For group A patients, the mean trough level of the EVR was 3.47±1.53 ng/ml (range, 1.5-11.2) with a daily dose of 1.00±0.25 mg/day. For group A and B, the average TAC trough levels were 6.97±3.98 ng/ml (range, 2.50 to 11.28 ng/ml) and 6.93±2.58 (range, 2-16.30), respectively. The 1-year, 3-year and 4-year overall survival achieved for Group A patients was 94.95%, 86.48% and 86.48%, respectively while for Group B patients it was 82.75%,68.96%, and 62.06%, respectively (p=0.0217). Conclusions: EVR use in liver transplant recipients in the early stage after transplantation reduces the HCC recurrence rates in HCC patients within the UCSF criteria.
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Thorat Ashok 한국인도학회 2007 印度硏究 Vol.12 No.2
A ray passing through water changes its direction. It is known as refraction. Similarly, a language passing through an alien culture is bound to change its nature. English in India shows indelible marks of this ‘refraction phenomenon’. The arrival of English in the Indian Sub continent as an alien language, its subsequent acculturation through contact with local languages and cultures and the consequent emergence of local varieties of English present an interesting field of study for sociolinguists. The present paper aims at discussing the different aspects of this process of change. The first part of the paper briefly summarizes the spread, pervasiveness and emergence of varieties of English. It is followed by a detailed discussion of the changing English in India. The focus is on the refraction phenomenon, i.e., rebirth of English as a result of its contact with local languages and cultures. Though the changes occur at different levels like the phonological, lexical, syntactic and semantic, marked examples related to the last three levels are discussed in order to bring into focus the authenticity and legitimacy of ‘Indian English’ as an independent variety.
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Immobilization of cellulase on functionalized cobalt ferrite nanoparticles
Shivaji Hariba Pawar,Raghvendra Ashok Bohara,Nanasaheb Devappa Thorat 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.1
Amine functionalized cobalt ferrite (AF-CoFe2O4) magnetic nanoparticles (MNPs) were used for immobilization of cellulase enzyme via 1-ethyl-3-[3-dimethylaminopropyl] carbodiimide hydrochloride (EDS) and N-hydroxysuccinimide (NHS) coupling reaction. The structural, morphological and magnetic properties of AF-CoFe2O4 were determined. TEM micrograph revealed a mean diameter of ~8 nm and showed that the AF-CoFe2O4 remain distinct with no significant change in size after binding with cellulase. Fourier transform infrared (FT-IR) spectroscopy confirmed the binding of cellulase to AF-CoFe2O4. The properties of immobilized cellulase were investigated by optimizing binding efficiency, pH, temperature and reusability. The results showed that the immobilized cellulase has higher thermal stability than free cellulase, which might be due to covalent interaction between cellulase and AF-CoFe2O4 surface. The immobilized cellulase also showed good reusability after recovery. Therefore, AF-CoFe2O4 MNPs can be considered as promising candidate for enzyme immobilization.
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