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RISS 인기검색어
- 검색키워드
- 저자 : Ashaimaa Y. Moussa (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Ahmed Esmat,Fahad A. Al-Abbasi,Mardi M. Algandaby,Ashaimaa Y. Moussa,Rola M. Labib,Nahla A. Ayoub,Ashraf B. Abdel-Naim 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.3
The present study aimed at isolating and elucidating the structure of the main components of Pistacia khinjuk L. and exploring its potential anti-inflammatory effect in different experimental models. The extract was evaluated for antiinflammatory activity by measuring paw volume in three experimental models. Then, prostaglandin E2 (PGE2) level, ear edema, tissue myeloperoxidase (MPO) activity, histopathology, nitric oxide (NO) level, and tumor necrosis factor-a (TNF-a) level were assessed. Seven phenolic compounds, mainly flavonoids and galloylated compounds, were isolated from the aqueous methanol extract: gallic acid (1), methyl gallate (2), quercetin-3-O-b-d-4C1-galactopyranoside (hyperin) (3), myricetin- 3-O-a-l-1C4-rhamnopyranoside (myricitrin) (4), 1,6-digalloyl-b-d-glucose (5), 1,4-digalloyl-b-d-glucopyranoside (6), and 2,3-di-O-galloyl-(a/b)-4C1-glucopyranose (nilocitin) (7). The anti-inflammatory activity was evidenced by decreased carrageenan-induced rat paw edema and PGE2 elevation. In the croton oil–induced ear edema model, MPO activity was significantly inhibited, and inflammatory histopathological changes were ameliorated. In the rat air pouch model, NO generation and TNF-a release were significantly inhibited. The isolation and nuclear magnetic resonance spectral data of compound 6 from the genus Pistacia are revealed for the first time. Also, P. khinjuk L. aqueous methanol extract possesses anti-inflammatory activity in several experimental models.
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Abdullah Alanzi,Esraa A. Elhawary,Mohamed L. Ashour,Ashaimaa Y. Moussa 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.4
There is an urgent need for novel antibiotics to combat emerging resistant microbial strains. One of the most pressing resources is Aspergillus microbial cocultures. The genome of Aspergillus species comprises a far larger number of novel gene clusters than previously expected, and novel strategies and approaches are essential to exploit this potential source of new drugs and pharmacological agents. This is the first review consulting recent developments and chemical diversity of Aspergillus cocultures and highlighting its untapped richness. The analyzed data revealed that cocultivation of several Aspergillus species with other microorganisms, including bacteria, plants, and fungi, is a source of novel bioactive natural products. Various vital chemical skeleton leads were newly produced or augmented in Aspergillus cocultures, among which were taxol, cytochalasans, notamides, pentapeptides, silibinin, and allianthrones. The possibility of mycotoxin production or complete elimination in cocultivations was detected, which pave the way for better decontamination strategies. Most cocultures revealed a remarkable improvement in their antimicrobial or cytotoxic behavior due to their produced chemical patterns; for instance, weldone and asperterrin whose antitumor and antibacterial activities, respectively, were superior. Microbial cocultivation elicited the upregulation or production of specific metabolites whose importance and significance are yet to be revealed. With more than 155 compounds isolated from Aspergillus cocultures in the last 10 years, showing overproduction, reduction, or complete suppression under the optimized coculture circumstances, this study filled a gap for medicinal chemists searching for new lead sources or bioactive molecules as anticancer agents or antimicrobials.
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Abdel Nasser B. Singab,Esraa A. Elhawary,Yasmin A. Elkhawas,Iten M. Fawzy,Ashaimaa Y. Moussa,Nada M. Mostafa 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Obesity and its comorbidities represent a major health problem worldwide. Treatment by reducing food intakeand physical activity interventions has limited success especially with elderly people with chronic diseases. Nutraceuticals arenaturally originated and successfully used for their physiological and nutritional benefit in health care. They might bealternative means to help lose weight and reduce obesity-associated metabolic disorders with the improvement of health, delaythe aging process, prevention of chronic diseases, increase of life expectancy, or support to the structure or function of thebody. The current study enumerates the inherent role of nutraceuticals in the management of obesity and its related comorbidities. The study is supported with the molecular docking studies discussing the mechanism of action. An attempt tooptimize the role of nutraceuticals is made in this article in addition to widen the scope of its use in this chronic worldwidedisease.
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