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RISS 인기검색어
- 검색키워드
- 저자 : Abdel Nasser B. Singab (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Singab, Abdel Nasser B.,Youssef, Diaa T.A.,Noaman, Eman,Kotb, Saeed The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.7
The hepatoprotective activity of flavonol glycosides rich fraction (F-2), prepared from 70% alcohol extract of the aerial parts of V calcarata Desf., was evaluated in a rat model with a liver injury induced by daily oral administration of $CCl_4$ (100 mg/kg, b.w) for four weeks. Treatment of the animals with F-2 using a dose of (25 mg/kg, b.w) during the induction of hepatic damage by $CCl_4$ significantly reduced the indices of liver injuries. The hepatoprotective effects of F-2 significantly reduced the elevated levels of the following serum enzymes: alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH). The antioxidant activity of F-2 markedly ameliorated the antioxidant parameters including glutathione (GSH) content, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), plasma catalase (CAT) and packed erythrocytes glucose-6-phosphate dehydrogenase (G6PDH) to be comparable with normal control levels. In addition, it normalized liver malondialdehyde (MDA) levels and creatinine concentration. Chromatographic purification of F-2 resulted in the isolation of two flavonol glycosides that rarely occur in the plant kingdom, identified as quercetin-3,5-di-O-$\beta$-D-diglucoside (5) and kaempferol-3,5-di-O-$\beta$-D-diglucoside (4) in addition to the three known compounds identified as quercetin-3-O-$\alpha$-L-rhamnosyl- (${\rightarrow}6$)-$\beta$-D-glucoside [rutin, 3], quercetin-3-O-$\beta$-D-glucoside [isoquercitrin, 2] and kaempferol-3-O-$\beta$-D-glucoside [astragalin, 1]. These compounds were identified based on interpretation of their physical, chemical, and spectral data. Moreover, the spectrophotometric estimation of the flavonoids content revealed that the aerial parts of the plant contain an appreciable amount of flavonoids (0.89%) calculated as rutin. The data obtained from this study revealed that the flavonol glycosides of F-2 protect the rat liver from hepatic damage induced by $CCl_4$ through inhibition of lipid peroxidation caused by $CCl_4$ reactive free radicals.
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Flavonoids from Iris spuria (Zeal) Cultivated in Egypt
Singab, Abdel Nasser B. The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.10
A new 12a-dehydrorotenoid 1, 11-dihydroxy-9, 10-methylenedioxy-12a-dehydrorotenoid (1), together with a new isoflavonoid glycoside tectorigenin-7-O-${\beta}$-glucosyl-4'-O-${\beta}$-glucoside (3), were isolated and identified from the rhizomes of I. spuria (Zeal). In addition, 4 known compounds, tectorigenin (2) tectorigenin-7-O-${\beta}$-glucosyl $(1{\leftrightarrow}6)$ glucoside (4), tectoridin (a tectorigenin- 7-O-${\beta}$-glucoside) (5) and tectorigenin-4'-O-${\beta}$-glucoside (6) were isolated and identified for the first time from this plant. The structures of the isolated compounds were determined by spectroscopic methods (UV, IR, $^1H,\;^{13}C$NMR, DEPT, HMQC, NOESY, and HMBC experiments and MS spectrometry) and by comparison with literature data of known compounds. Compounds 2, 4, 5, and 6 are reported for the first time from this plant through the present study.
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Abdel Nasser B. Singab,Esraa A. Elhawary,Yasmin A. Elkhawas,Iten M. Fawzy,Ashaimaa Y. Moussa,Nada M. Mostafa 한국식품영양과학회 2024 Journal of medicinal food Vol.27 No.2
Obesity and its comorbidities represent a major health problem worldwide. Treatment by reducing food intakeand physical activity interventions has limited success especially with elderly people with chronic diseases. Nutraceuticals arenaturally originated and successfully used for their physiological and nutritional benefit in health care. They might bealternative means to help lose weight and reduce obesity-associated metabolic disorders with the improvement of health, delaythe aging process, prevention of chronic diseases, increase of life expectancy, or support to the structure or function of thebody. The current study enumerates the inherent role of nutraceuticals in the management of obesity and its related comorbidities. The study is supported with the molecular docking studies discussing the mechanism of action. An attempt tooptimize the role of nutraceuticals is made in this article in addition to widen the scope of its use in this chronic worldwidedisease.
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