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I.S.R.Punitha1,,Nalini Bhat3,,K.Rajendran1,,Arun Shirwaikar2,,Annie Shirwaikar1 한국생약학회 2005 Natural Product Sciences Vol.11 No.3
The aqueous extract of Coscinium fenestratum was studied for its antioxidant status in STZ-nicotinamide induced type 2 diabetic rats at two dose levels of 250 mg/kg and 500 mg/kg. At the end of theexperimental period, diabetic rats treated with aqueous extract at both dose levels showed a significant increase insuperoxide dismutase and catalase as compared to the untreated control. Similarly, a significant increase was alsoobserved in the levels of the non enzymatic antioxidants ceruloplasmin, ascorbic acid and tocopherol. The resultssuggest that the aqueous stem extract of C. fenestratum prevents type 2 diabetes mellitus induced oxidative stress.
Antioxidant Studies on the Methanol Stem Extract of Coscinium fenestratum
Annie Shirwaikar,Arun Shirwaikar,I.S.R. Punitha 한국생약학회 2007 Natural Product Sciences Vol.13 No.1
methanol extract of Coscinium fenestratum, commonly known as tree turmeric, which is widelyused in the indigenous system of medicine was studied for its in vitro scavenging activity in different methods vizDPPH scavenging, nitric oxide scavenging, iron chelation activity, superoxide scavenging, ABTS radicalscavenging and lipid peroxidation. The results were analyzed statistically by regression method. Its antioxidantactivity was estimated by IC50 value and the values are 57.1 .g/ml for DPPH radical scavenging, 36.5 .g/ml forsuperoxide scavenging, and 40 .g/ml for lipid peroxidation. In all the methods, the extract showed its ability toscavenge free radicals in a concentration dependent manner. The results indicate that C. fenestratum has potentantioxidant activity.KeywordsCoscinium fenestratum, nitric oxide, ABTS, DPPH, lipid peroxidation, superoxide.
Free Radical Scavenging and Lipid Peroxidation Inhibition Potential of Hygrophila auriculata
Madhavan Vijayakumar,Raghavan Govindarajan,Arun Shirwaikar,Vivek Kumar,Ajay Kumar Singh Rawat,Shanta Mehrotra,Palpu Pushpangadan 한국생약학회 2005 Natural Product Sciences Vol.11 No.1
Hygrophila auriculata (K. Schum.) Heine is a wild herb comonly found in moist places on thebanks of tanks, ditches and paddy fields throughout India and is one of the main sources of Ayurvedic ?Rasayanadrug. The free radical scavenging potential of 50% aqueous alcoholic extract of H. auriculata (HAEt) was studiedfor DPPH scavenging activity, nitric oxide, hydroxyl radical and ferryl bipyridyl complex scavenging activity(TBARS) in rat liver homogenate. Integral antioxidative capacity was determined by photochemiluminescence assay.HAEt showed good radical scavenging activity at various concentrations (200-1000 g/ml) against 1,1 diphenyl,2-picrylhydrazyl (DPPH) (32.32-77.02%) with moderate scavenging activity against Nitric oxide (12.46-52.84%),hydroxyl radical (11.69-55.26%), ferryl bipyridyl complex (17.66-58.67%) and lipid peroxidation (0.829-0.416nmoles/mg protein). The above results indicate HAEt varied therapeutic activities claimed for the plant in the Indian indigenous systems of medicine may be in part dueto the free radical scavenging and/ or potent antioxidant activity.Keywords Hygrophila auriculata, free radical scavenging, Lipid peroxidation, Photochemiluminescence assay
Pharmacognostical Evaluation of Clerodendrum viscosum (Vent.)
Richard Lobo,C. Dinesh Kumar,I. S. R. Punitha,K. Rajendran,Arun Shirwaikar,Annie Shirwaikar 한국생약학회 2006 Natural Product Sciences Vol.12 No.2
study presents a detailed pharmacognostical study of the root and leaf of the crude drugClerodendrum viscosum Vent. (Verbenaceae), an important plant in the Indian system of medicine. The root andleaf samples were studied using light and confocal microscopy, WHO recommended-physicochemicaldeterminations, and authentic phytochemical procedures. The physicochemical, morphological, and histologicalparameters presented in this paper may be proposed as parameters to establish the authenticity of C. viscosum rootand leaf, and may possibly help to diferentiate the drug from its other species.KeywordsClerodendrum viscosum, Verbenaceae, pharmacognosy, root and leaf
Richard Lobo,I.S.R. Punitha,K. Rajendran,Arun Shirwaikar,Annie Shirwaikar 한국생약학회 2006 Natural Product Sciences Vol.12 No.3
antisnake venom activity of Clerodendrum viscosum Vent. (Fam. Verbenaceae), a plant traditionallyused in India for the treatment of snake bite was evaluated by in vitro and in vivo methods. While in vitro studieswere performed using human blood, in vivo studies were carried out using mice administered three different i.pdoses of the extract, 5 min before the administration of Naja naja snake venom. The results of the in vitro studiesin vivo studies, theextract showed significant antisnake venom activity, which may be attributed to its possible interference with theacetylcholine receptor sites. Hence the present investigation justifies the traditional use of Clerodendrum viscosum(C. viscosum) as antisnake venom. KeywordsClerodendrum viscosum, Naja naja, snake venom, verbenaceae, alcoholic extract