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Deepti Arun Phansopkar,Jaineet Sachdeva,Manmohan Krishan Mahajan,Pamela Alice Kingsley,Shekhar Upadhyay,Rajesh Chakravarti 대한종양외과학회 2015 Korean Journal of Clinical Oncology Vol.11 No.2
Purpose: This study evaluates the dose distribution of tangential beam intensity modulated radiotherapy (IMRT) compared to tangential beam three-dimensional conformal radiotherapy (3D-CRT) in carcinoma breast. Methods: Tangential beam IMRT and tangential beam 3D-CRT plans were generated in 54 postoperative breast cancer patients. Planning target volume (PTV) definition of chest wall and intact breast was done according to Breast Cancer Atlas for Radiation Therapy Oncology Group. The prescribed dose was 50 Gy in 25 fractions. Dose volume histograms was evaluated for PTV and organs at risk, parameters of the dose distribution were compared for 3D-CRT and IMRT using Wilcoxon Matched pairs test. The dosages were clinically correlated with normal tissue reactions. Results: No difference in the conformity index but IMRT improves the homogeneity index significantly (P<0.01). The mean dose to all organs at risk was lesser in IMRT as compared to 3D-CRT of which the dose to contralateral lung was significantly lower with IMRT (111.7 cGy vs. 41.98 cGy, P=0.024). Tangential beam IMRT significantly reduces ipsilateral lung V20% by 24%. Heart V70% is decreased by V74% and V30% by V38% doses but not statistically significant. Conclusion: Tangential beam IMRT in breast cancer offers the potential to significantly reduce the dose-volume of the ipsilateral lung and dose volume of the heart which will translate into decrease in risk of cardiac and lung toxicity and also decreased second cancer risk. IMRT definitely decreases the acute skin reactions in all patients.
Devinder Singh,Sushma Sharma,Arun Mahajan,Suram Singh,Rajinder Singh 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.6
Intergrowth perovskite type complex oxides La0.8Ln0.2Sr2MnCrO7-δ (Ln=La, Nd, Gd, and Dy) have been synthesized by sol-gel method. Rietveld profile analysis shows that the phases crystallize with tetragonal unit cell in the space group I4/mmm. The unit cell parameters a and c decrease with decreasing effective ionic radius of the lanthanide ion. The magnetic studies suggest that the ferromagnetic interactions are dominant due to Mn3+–O–Mn4+ and Mn3+–O–Cr3+ double exchange interactions. Both Weiss constant (θ) and Curie temperature (TC) increase with decreasing ionic radius of lanthanide ion. It was found that the transport mechanism is dominated by Mott’s variable range hopping (VRH) model with an increase of Mott localization energy.
Singh, Devinder,Sharma, Sushma,Mahajan, Arun,Singh, Suram,Singh, Rajinder Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.6
Intergrowth perovskite type complex oxides $La_{0.8}Ln_{0.2}Sr_2MnCrO_{7-{\delta}}$ (Ln=La, Nd, Gd, and Dy) have been synthesized by sol-gel method. Rietveld profile analysis shows that the phases crystallize with tetragonal unit cell in the space group I4/mmm. The unit cell parameters a and c decrease with decreasing effective ionic radius of the lanthanide ion. The magnetic studies suggest that the ferromagnetic interactions are dominant due to $Mn^{3+}$-O-$Mn^{4+}$ and $Mn^{3+}$-O-$Cr^{3+}$ double exchange interactions. Both Weiss constant (${\theta}$) and Curie temperature ($T_C$) increase with decreasing ionic radius of lanthanide ion. It was found that the transport mechanism is dominated by Mott's variable range hopping (VRH) model with an increase of Mott localization energy.