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Arrigoni Battaia, F.,Chen, Chian-Chou,Fumagalli, M.,Cai, Zheng,Calistro Rivera, G.,Xu, Jiachuan,Smail, I.,Prochaska, J. X.,Yang, Yujin,De Breuck, C. Springer-Verlag 2018 Astronomy and astrophysics Vol.620 No.-
<P>In the hierarchical model of structure formation, giant elliptical galaxies form through merging processes within the highest density peaks known as protoclusters. While high-redshift radio galaxies usually pinpoint the location of these environments, we have recently discovered at <I>z</I> ∼ 2−3 three enormous (> 200 kpc) Lyman-<I>α</I> nebulae (ELANe) that host multiple active galactic nuclei (AGN) and that are surrounded by overdensities of Lyman-<I>α</I> emitters (LAE). These regions are prime candidates for massive protoclusters in the early stages of assembly. To characterize the star-forming activity within these rare structures - both on ELAN and protocluster scales - we have initiated an observational campaign with the <I>James Clerk Maxwell</I> Telescope (JCMT) and the Atacama Pathfinder EXperiment (APEX) telescopes. In this paper we report on sensitive SCUBA-2/JCMT 850 and 450 <I>μ</I>m observations of a ∼128 arcmin<SUP>2</SUP> field comprising the ELAN MAMMOTH-1, together with the peak of the hosting BOSS1441 LAE overdensity at <I>z</I> = 2.32. These observations unveil 4.0 ± 1.3 times higher source counts at 850 <I>μ</I>m with respect to blank fields, likely confirming the presence of an overdensity also in obscured tracers. We find a strong detection at 850 <I>μ</I>m associated with the continuum source embedded within the ELAN MAMMOTH-1, which - together with the available data from the literature - allow us to constrain the spectral energy distribution of this source to be of an ultra-luminous infrared galaxy (ULIRG) with a far-infrared luminosity of LFIR<SUP>SF</SUP> = 2.4−2.1<SUP>+7.4</SUP>×10<SUP>12</SUP><I>L</I>⊙, and hosting an obscured AGN. Such a source is thus able to power a hard photoionization plus outflow scenario to explain the extended Lyman-<I>α</I>, He II<I>λ</I>1640, and C IV<I>λ</I>1549 emission, and their kinematics. In addition, the two brightest detections at 850 <I>μ</I>m (<I>f</I>850 > 18 mJy) sit at the density peak of the LAEs’ overdensity, likely pinpointing the core of the protocluster. Future multiwavelength and spectroscopic datasets targeting the full extent of the BOSS1441 overdensity have the potential to firmly characterize a cosmic nursery of giant elliptical galaxies, and ultimately of a massive cluster.</P>
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Manuela Teresa Raimondi,Serena Bertoldi,Silvia Caddeo,Silvia Farè,Chiara Arrigoni,Matteo Moretti 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.4
The purpose of this study was to measure chondrocytes detachment from cellularized constructs cultured in a perfusion bioreactor, and to evaluate the effect of different scaffold coatings on cell adhesion under a fixed flow rate. The scaffolds were polyurethane foams, treated to promote cell attachment and seeded with human chondrocytes. In a preliminary static culture experiment, the scaffolds were imbibed with fetal bovine serum (FBS) and then cultured for 4 weeks. To quantify cell detachment, the number of detached cells from the scaffold treated with FBS was estimated under different interstitial perfusion flow rates and shear stress levels (0.005 mL/min equivalent to 0.05 mPa, 0.023 mL/min equivalent to 0.23 mPa, and 0.045 mL/min equivalent to 0.45 mPa). Finally, groups of scaffolds differently treated (FBS, plasma plus FBS, plasma plus collagen type I) were cultured under a fixed perfusion rate of 0.009 mL/min, equivalent to a shear stress of 0.09 mPa, and the detached cells were counted. Static cultivation showed that cell proliferation increased with time and matrix biosynthesis decreased after the first week of culture. Perfused culture showed that the number of detached cells increased with the perfusion rate on FBS-treated constructs. The plasma-treated/collagen-coated scaffolds showed the highest resistance to cell detachment. To minimize cell detachment, the perfusion rate must be maintained in the order of 0.02 mL/min, giving a shear stress of 0.2 mPa. Our set-up allowed estimating the resistance to cell detachment under interstitial perfusion in a repeatable manner, to test other scaffold coatings and cell types.
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Modified Research Utilization Questionnaire: Development and Validation Study among Italian Nurses
Rosario Caruso,Anna M. Grugnetti,Umberto Pastore,Federica Dellafiore,Francesco Pittella,Davide Ausili,Alessandro Stievano,Cristina Arrigoni 한국간호과학회 2019 Asian Nursing Research Vol.13 No.1
Purpose: The purpose of this study was to develop the modified research utilization questionnaire (MRUQ) and to establish its content and face validity, construct validity, and reliability. Methods: This study has a multiphase (three phases), methodological, and cross-sectional design. First, research utilization questionnaire (RUQ) was translated into Italian, which is the target language to develop the M-RUQ. Second, the RUQ psychometric proprieties were assessed using exploratory factorial analysis to identify ambiguous or problematic items (e.g., cross-loadings) (cross-sectional sampling A). The RUQ modification (i.e., item deleting, wording modification, and scoring procedure) represented the development of the M-RUQ among Italian nurses. The third phase was aimed to confirm the construct validity of the M-RUQ and to test its stability and internal consistency (crosssectional sampling B). Results: This study's findings show that M-RUQ has a three-dimensional structure and a total of 22 items. The M-RUQ shows evidence of validity and reliability. Precisely, the factorial structure coming from an exploratory factorial analysis on the first sample (n ¼ 504) was confirmed by a final model of confirmatory factorial analysis (CFA) on a second sample (n ¼ 362). The final CFA model showed adequate goodness of fit, where all the factor loadings showed values higher than .40. Cronbach's a was satisfactory for each domain and for the overall scale. Furthermore, the M-RUQ showed good stability described by the testeretest. Conclusion: The M-RUQ should be used to assess research utilization among nurses for educational or research purposes to address the practice. Further research about its validity and reliability is suggested.
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The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
Stunnenberg, Hendrik G.,Abrignani, Sergio,Adams, David,de Almeida, Melanie,Altucci, Lucia,Amin, Viren,Amit, Ido,Antonarakis, Stylianos E.,Aparicio, Samuel,Arima, Takahiro,Arrigoni, Laura,Arts, Rob,Asn Cell Press 2016 Cell Vol. No.
<P>The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC web portal at http://www.cell.com/consortium/IHEC) highlight the coordinated achievements of IHEC teams to gather and interpret comprehensive epigenomic datasets to gain insights in the epigenetic control of cell states relevant for human health and disease.</P> <P><B>PaperClip</B></P> <P>Display Omitted</P>
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