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Elisabetta Cavalcanti,Raffaele Armentano,Ivan Lolli 대한암학회 2020 Cancer Research and Treatment Vol.52 No.4
Recently, there have been a few reports of rituximab (RTX)-induced Crohn’s disease, but there is no literature available on successful long-term treatment and the clinical outcome of this condition. We retrospectively analyzed the clinical data of a rare case of Crohn’s disease induced by RTX administered as induction and prolonged maintenance therapy of a follicular lymphoma, diagnosed synchronously with a gastric signet ring cells carcinoma, treated at our hospital.
Rathbun, Francesca M.,Pralle, Ryan S.,Bertics, Sandra J.,Armentano, Louis E.,Cho, K.,Do, C.,Weigel, Kent A.,White, Heather M. Elsevier 2017 Journal of dairy science Vol.100 No.5
<P>Extensive efforts have been made to identify more feed-efficient dairy cows, yet it is unclear how selection for feed efficiency will influence metabolic health. The objectives of this research were to determine the relationships between residual feed intake (RFI), a measure of feed efficiency, body condition score (BCS) change, and hyperketonemia. (HYK) incidence. Blood and milk samples were collected twice weekly from cows 5 to 18 d postcalving for a total of 4 samples. Hyperketonemia was diagnosed at a blood beta-hydroxybutyrate (BHB) >= 1.2 nanol/L and cows were treated upon diagnosis. Dry period, calving, and final blood sampling BCS was recorded. Prior mid-lactation production, body weight, body weight change, and dry matter intake (DMI) data were used to determine RFI phenotype, calculated as the difference between observed DMI and predicted DMI. The maximum BHB concentration (BHBmax) for each cow was used to group cows into HYK or not hyperketonemic. Lactation number, BCS. and RFI data were analyzed with linear and quadratic orthogonal contrasts. Of the 570 cows sampled, 19.7% were diagnosed with HYK. The first positive HYK test occurred at 9 +/- 0.9 d postpartum and the average BHB concentration at the first positive HYK test was 1.53 +/- 0.14 mmol/L. In the first 30 d postpartum, HYK-positive cows had increased milk yield and fat concentration, decreased milk protein concentration, and decreased somatic cell count. Cows with a dry BCS >= 4.0; or that lost 1 or more BCS unit across the transition to lactation period, had greater BHBmax than cows with lower BCS. Prior-lactation RFI did not alter BHBmax. Avoiding over conditioning of dry cows and subsequent excessive fat mobilization during the transition period may decrease HYK incidence; however, RFI. during a prior lactation does riot appear to be associated with HYK onset.</P>
Wands,JR,Yoon,SK,Mohr,L,Oiordan,C,Armentano,D 가톨릭중앙의료원 가톨릭암센터 1998 암심포지움 Vol.- No.2
Aims: Recombinant adenovirus vectors are very attractive for gene delivery if specifically targeted malignent cells. In this study we developed an approach to target adenoviral vectors using AF-20 mAb that binds to a 180 kDa antigen which is highly expressed on HCC cells using a bifunctional Fab complex (Bi-Fab) to induce tumor cell specific gene delivery.