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Development and investigation of multi-layered homo- and hetero-type DNA thin films
Arasu, Velu,Jeon, Sohee,Jeong, Jun-Ho,Park, Sung Ha The Royal Society of Chemistry 2018 Journal of materials chemistry. C, Materials for o Vol.6 No.19
<P>DNA molecules have been studied for specific target applications because of their characteristics and modification abilities. Although the fabrication of 2D multi-layered DNA thin films has been demonstrated, limitations in their applications exist due to difficulties in controlling the layer thickness and fabricating hetero-stacking structures. Here, multi-layered homo- and hetero-type DNA and cetyltrimethyl-ammonium chloride (CTMA)-modified DNA thin films are fabricated <I>via</I> spin-coating and their physical characteristics are investigated. The thickness and the multilayer stacking influenced by the solvents, concentration, and spin-speed of the sample solution are also discussed. While DNA layers can be stacked either on a DNA or on a CTMA-modified DNA layer with the resulting thicknesses of approximately 100 and 300 nm, respectively, the CTMA-modified DNA layer cannot be stacked on a CTMA-modified DNA layer because of its solubility in the solvent. The optical and mechanical characteristics of the thin films indicate their dependency on film thickness. In addition, we fabricate the luminophore-embedded DNA and CTMA-DNA thin films with homo- and hetero-type layer stackings and measure the absorbance and photoluminescence spectra to show the feasibility in constructing functionalized multi-layered thin films. The homo- and hetero-type DNA layers and their revealed physical characteristics provide a platform for the construction of useful devices and sensors and a perspective for better understanding the applications in coating, transparent electrodes, transistors, and drug delivery.</P>
Arasu, Velu,Reddy Dugasani, Sreekantha,Son, Junyoung,Gnapareddy, Bramaramba,Jeon, Sohee,Jeong, Jun-Ho,Ha Park, Sung IOP 2017 Journal of Physics. D, Applied Physics Vol.50 No.41
<P>Although the preparation of DNA thin films with well-defined thicknesses controlled by simple physical parameters is crucial for constructing efficient, stable, and reliable DNA-based optoelectronic devices and sensors, it has not been comprehensively studied yet. Here, we construct DNA and surfactant-modified DNA thin films by drop-casting and spin-coating techniques. The DNA thin films formed with different control parameters, such as drop-volume and spin-speed at given DNA concentrations, exhibit characteristic thickness, surface roughness, surface potential, and absorbance, which are measured by a field emission scanning electron microscope, a surface profilometer, an ellipsometer, an atomic force microscope, a Kelvin probe force microscope, and an UV–visible spectroscope. From the observations, we realized that thickness significantly affects the physical properties of DNA thin films. This comprehensive study of thickness-dependent characteristics of DNA and surfactant-modified DNA thin films provides insight into the choice of fabrication techniques in order for the DNA thin films to have desired physical characteristics in further applications, such as optoelectronic devices and sensors.</P>
Arasu Abirami,Prabha Nagaram,Devi Durga,Issac Praveen Kumar,Alarjani Khaloud Mohammed,Al Farraj Dunia A.,Aljeidi Reem A.,Tayyeb Jehad Zuhair,Guru Ajay,Arockiaraj Jesu,Mohan Magesh,Hussein Dina S. 한국미생물학회 2023 The journal of microbiology Vol.61 No.11
Listeria monocytogenes is an important food-borne pathogen that causes listeriosis and has a high case fatality rate despite its low incidence. Medicinal plants and their secondary metabolites have been identified as potential antibacterial substances, serving as replacements for synthetic chemical compounds. The present studies emphasize two significant medicinal plants, Allium cepa and Zingiber officinale, and their efficacy against L. monocytogenes. Firstly, a bacterial isolate was obtained from milk and identified through morphology and biochemical reactions. The species of the isolate were further confirmed through 16S rRNA analysis. Furthermore, polar solvents such as methanol and ethanol were used for the extraction of secondary metabolites from A. cepa and Z. officinale. Crude phytochemical components were identified using phytochemical tests, FTIR, and GC–MS. Moreover, the antibacterial activity of the crude extract and its various concentrations were tested against L. monocytogenes. Among all, A. cepa in methanolic extracts showed significant inhibitory activity. Since, the A. cepa for methanolic crude extract was used to perform autography to assess its bactericidal activity. Subsequently, molecular docking was performed to determine the specific compound inhibition. The docking results revealed that four compounds displayed strong binding affinity with the virulence factor Listeriolysin-O of L. monocytogenes. Based on the above results, it can be concluded that the medicinal plant A. cepa has potential antibacterial effects against L. monocytogenes, particularly targeting its virulence.
Arasu, K.T.,Bhandari, Ashwani K.,Ma, Siu-Lun,Sehgal, Surinder Department of Mathematics 2005 Kyungpook mathematical journal Vol.45 No.1
We introduce the concept of what we call "regular difference covers" and prove many nonexistence results and provide some new constructions. Although the techniques employed mirror those used to investigate difference sets, the end results in this new setting are quite different.
Incidence and risk factors of dysphagia after variceal band ligation
Saraswathi Arasu,Hammad Liaquat,Jaspreet Suri,Adam C. Ehrlich,Frank K Friedenberg 대한간학회 2019 Clinical and Molecular Hepatology(대한간학회지) Vol.25 No.4
Background/Aim: There is a lack of data on long-term morbidity, particularly dysphagia, following endoscopic variceal band ligation (EVL). The aim of this study are to assess the incidence of dysphagia and variables associated with this complication after EVL. Methods: We identified individuals who completed at least one session of EVL as their sole treatment for varices from August 2012 to December 2017. Included patients achieved “complete eradication” of varices not requiring further therapy. Patients ≥90 days from their last EVL session completed a modified version of the Mayo Clinic Dysphagia Questionnaire. Individuals with dysphagia were invited to undergo a barium esophagram. Patients with pre-EVL dysphagia were excluded. Results: Of the patients, 68 possessed inclusion criteria, nine (13.2%) died and 20 (29.4%) were lost to follow up. For the remaining 39 (57.4%) patients, 23 were males, mean age of 61.7±8.6 years. The most common etiology of liver disease was hepatitis C virus (n=18; 46.2%). The median number of banding sessions was 2.0 (interquartile range [IQR], 1.0–4.0) with a median of 9.0 bands placed (IQR, 3.0–14.0). Twelve patients (30.8%) developed new-onset dysphagia post-EVL. In univariate analysis, pre-EVL MELD score and non-emergent initial banding were associated with long-term dysphagia. In a regression model adjusted for age, sex, number of bands, and use of acid suppression after EVL, no factor was independently associated with dysphagia (all P>0.05). No strictures were identified on subsequent esophageal evaluation. Conclusions: Approximately 30% of patients developed new-onset, chronic dysphagia post-EVL. Incident dysphagia was associated with a non-emergent initial banding session. The mechanism for dysphagia remains unknown.
SECURE DOMINATION PARAMETERS OF HALIN GRAPH WITH PERFECT K-ARY TREE
R. ARASU,N. PARVATHI The Korean Society for Computational and Applied M 2023 Journal of applied mathematics & informatics Vol.41 No.4
Let G be a simple undirected graph. A planar graph known as a Halin graph(HG) is characterised by having three connected and pendent vertices of a tree that are connected by an outer cycle. A subset S of V is said to be a dominating set of the graph G if each vertex u that is part of V is dominated by at least one element v that is a part of S. The domination number of a graph is denoted by the γ(G), and it corresponds to the minimum size of a dominating set. A dominating set S is called a secure dominating set if for each v ∈ V\S there exists u ∈ S such that v is adjacent to u and S<sub>1</sub> = (S\{v}) ∪ {u} is a dominating set. The minimum cardinality of a secure dominating set of G is equal to the secure domination number γ<sub>s</sub>(G). In this article we found the secure domination number of Halin graph(HG) with perfet k-ary tree and also we determined secure domination of rooted product of special trees.