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RISS 인기검색어
- 검색키워드
- 저자 : Vaibhav Rastogi (검색결과 2 건)
- 무료
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Vaibhav Rastogi,Pragya Yadav,Navneet Verma,Anurag Verma 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.3
The objective of this study was to design a novel microemulsion system for transdermal delivery of natural antimicrobial agent, i.e. bacteriophage (T4) specifically lysing E. coli bacteria. Pseudoternary phase diagrams were constructed and various formulations were prepared using a combination of ethyl oleate (oil), Tween 80:Span 20 (surfactant mixture) and water (aqueous phase). Developed formulations were subjected to physicochemical characterization, ex vivo and thermodynamic stability studies, skin irritation and histology studies. All the formulations had small droplet size (150–320nm), uniform size distribution (PI < 0.4), adequate viscosity and surface tension. 4 × 105, 6.02 × 106 and 6.7 × 106 PFU/mL was the cumulative amount of bacteriophage permeated from ME1-3, respectively. Results from permeation studies suggested the synergistic effect of oil and surfactant mixture on the permeation profile (p < 0.05), on increasing surfactant concentration with respect to oil, the bacteriophage permeation was increasing and so, the flux was increases too. ME2 was found to be thermodynamically stable, nonirritant and followed zero order kinetics. The bacteriophage viability to lyse E. coli was significantly affected at various temperatures, pH and dilution. Histological findings revealed the effect of formulation variables on the skin, necessary for permeation. These results indicate that microemulsion-based transdermal delivery of bacteriophage can be a promising approach to treat the infections caused by antibiotic-resistant bacteria but needs thorough clinical investigations.
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Pragya Yadav,Vaibhav Rastogi,Mayur Porwal,Prashant Upadhyay,Anurag Verma 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.6
3(2) factorial design and response surface methodology in the fabrication of matrix transdermal films of aceclofenac (ACL) was utilized in this study to investigate the effects of polymers (hydrophilic and hydrophobic) and penetration enhancer (PE) on ex vivo and in vivo drug performance. FTIR and DSC showed no interaction of drug with polymers. The physicochemical characterization showed uniformity among the formulations. Results from the permeation study suggested the effect of polyvinyl pyrrolidone (PVP K-30) and PE, on increasing concentration of PVP K-30 with respect to ethyl cellulose as well as increased concentration of PE resulted in enhanced permeation through the matrix. Significant effect of PE on the lipid and protein framework of the skin was also observed which is responsible for increased permeation. From response surface curve and contour plots, an optimized formulation was selected and evaluated for their ex vivo permeation, skin irritation, in vivo efficacy and stability studies. The optimized formulation showed Higuchi controlled diffusion and was found to be non-irritant and efficacious in reducing carrageenan induced paw edema in rats over a prolonged duration of time as compared to oral delivery. Thus, results indicated that the prepared transdermal system can be a promising non-oral approach to deliver effective amount of ACL to treat various inflammatory conditions.
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