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- 저자 : Annie George (검색결과 1 건)
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Efficacy and Safety of Labisia pumila var alata Water Extract Among Pre- and Postmenopausal Women
Mohd Noor Norhayati,Annie George,Nik Hussain Nik Hazlina,Abdul Kadir Azidah,Hassan Intan Idiana,Kim Sooi Law,Ismail Shaiful Bahari,Wan Mohamed Wan Zahiruddin,Eckehard Liske,Abas Azreena 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.8
This study evaluated the effectiveness and safety of Labisia pumila var alata (L. pumila) water extract for improving quality of life, cardiovascular and hormonal balance. A randomized, double-blind, placebo-controlled, parallel group, 16-week study in healthy pre- and postmenopausal women aged 40–60 years was conducted in Kelantan, Malaysia. The subjects were randomized to 400mg propriety extract of L. pumila or placebo. A Women’s Health Questionnaire was used to assess quality of life. Repeated-measures analysis of variance was used to evaluate the data. A total of 197 subjects (L. pumila: n = 102 and placebo: n = 95) were analyzed. Subjects in the herbal group showed improved memory/concentration, vasomotor symptoms, menstrual symptoms, and sleep problems by 8.3%, 15.9%, 11.8%, and 31.0%, respectively. The greatest improvement was observed for the question: ‘‘I get frightened or panic feelings for apparently no reason at all’’ with a 53% decrease as compared with placebo. Improvements were also seen in the cardiovascular parameters, and the safety profiles were normal. Postmenopausal women supplemented with L. pumila showed no changes in gynecological relevant hormones luteinizing hormone (LH), folliclestimulating hormone (FSH), and 17b-Estradiol.Water extract of L. pumila was shown to be safe and effective for improving several parameters of quality of life and cardiovascular risks factors (total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C]).
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