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Effect of N-acetyl-L-cysteine on human chronic myeloid leukemia cells KCL22 treated with mitomycin C
Simonyan, Anna,Hovhannisyan, Galina,Aroutiounian, Rouben,Kim, Jin Kyu The Ecological Society of Korea 2014 Journal of Ecology and Environment Vol.37 No.1
The effectiveness of N-acetyl-L-cysteine (NAC) to protect blood cells against Mitomycin C (MMC) induced genotoxicity was investigated in human chronic myeloid leukemia cells (KCL22) using the alkaline comet assay. The comet assay was selected as sensitive and rapid method for analysis of DNA damage and repair in individual cells. NAC treatment alone did not produce any damage in KCL22 cell. But NAC was found to be effective in reducing genotoxic damage in KCL22 cells exposed to MMC. These results confirm the literature data that, given the safety and ability to reduce DNA damage. NAC may be useful to prevent drug-mediated genotoxicity.
Effect of N-acetyl-L-cysteine on human chronic myeloid leukemia cells KCL22 treated with mitomycin C
Anna Simonyan,김진규,Galina Hovhannisyan,Rouben Aroutiounian 한국생태학회 2014 Journal of Ecology and Environment Vol.37 No.1
The effectiveness of N-acetyl-L-cysteine (NAC) to protect blood cells against Mitomycin C (MMC) induced genotoxicitywas investigated in human chronic myeloid leukemia cells (KCL22) using the alkaline comet assay. The comet assay wasselected as sensitive and rapid method for analysis of DNA damage and repair in individual cells. NAC treatment alonedid not produce any damage in KCL22 cell. But NAC was found to be effective in reducing genotoxic damage in KCL22cells exposed to MMC. These results confirm the literature data that, given the safety and ability to reduce DNA damage. NAC may be useful to prevent drug-mediated genotoxicity.