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Truc Cong Ho,Anley Teferra Kiddane,파즐러라만칸,Yeon-Jin Cho,박진석,Hee-Jeong Lee,GUN-DO KIM,Young-Mog Kim,Byung-Soo Chun 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.108 No.-
In this study, the pressurized liquid extraction (PLE) of total phenolic content (TPC), gallic acid (GA), andp-hydroxybenzoic acid (PHBA) from Pseuderanthemum palatiferum (Nees) Radlk. leaves was optimizedusing response surface methodology. The extract at the optimum conditions of TPC, namely OP, was characterizedusing GC–MS, HPLC, and spectrophotometry analysis. Furthermore, bio-functional properties ofthe OP, including antioxidant, antimicrobial, antihypertensive activities, and cytotoxicity against cancerand normal cell lines, were also investigated. The results showed that all extraction models were appropriatein predicting the extraction processes (p < 0.05) of the target compounds. In addition to TPC, GA,and PHBA, the OP also contains a high amount of other valuable components that contributed to itshighly biological activities. Moreover, the OP was nontoxic on HaCaT cells with a concentration of nomore than 1000 mg/mL. From the obtained results, PLE proved to be a suitable technique for the recoveryof bioactive compounds from P. palatiferum leaves.