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        Gastroprotective and digestive potential of an Ayurvedic asava–arishta preparation

        Anjan Adhikari,Amitabha Dey,Satyajyoti Kanjilal,Rajarshi Biswas,Deepa Gandhi,Kamarujjaman Mondal,Bibhuti Nath Bhatt,Tapas Kumar Sur,Satyabrata Mohapatra,Avinash Narwaria,Chandra Kant Katiyar 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.4

        Asavas and arishtas are considered as important Ayurvedic self-fermented dosage forms which are being used widely to promote health and well-being and for management of digestive and metabolic disorders. The present investigation was carried out to study the potential of an Ayurvedic polyherbal asava–arishta preparation (ZP) in gastroprotection, intestinal motility and gastric dyspepsia in experimental rodent models. The gastroprotective effect of ZP at doses 1.5, 3 and 6 ml/ kg of body weight was studied using battery of animal models such as pyloric ligation in rats, intestinal transit time using charcoal meal test, gastric emptying and digestive stimulation action in rats. In addition, anti-spasmodic activity was studied using isolated guinea pig’s ileum. The role digestive enzymes such as pepsin, α-amylase and lipase were accessed by various enzymatic assays. A dose-dependent and statistically significant (p < 0.01) inhibitory effect on reducing gastric volume, free acidity, total acidity and ulcer index were observed in ZP treated animals as compared to the control. ZP also enhanced the mucin content of the gastric juice. Pre-treatment with ZP produced a dose-dependent effect in reducing intestinal motility, intestinal spasms and increased the gastric emptying time in rats. These observations validated the age old claims of ZP for its use as digestive tonic. Thus, results concluded that ZP is having potential to improve digestion and reduces recurrent digestive ailments.

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        Prospective experimental studies of some herbs used in urinary disorders in Unani medicine

        Anjan Adhikari,Sangita Bhattacharya,Sankhadip Bose,Moumita Ray,Rania Indu,Sabyasachi Banerjee 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.3

        Diseases of the kidney and urinary tract including urolithiasis became a major cause of global illness and death. There are approximately 7.85 million people suffering from chronic renal failure in India. Further, urolithiasis is also a common global phenomenon of renal disorders. Unani Medicine (UM) is a famous kind of conventional medicine practised throughout South Asia that relies on the ancient conventional medicinal systems of India, Egypt, China, Iraq, Syria, and Persia. Berberis vulgaris (BV), Physalis alkekengi (PA) and Boswellia serrata (BS) are very common drugs against urinary disorders in Unani medicine. But, to establish their role to treat in urinary disorders are still obscure. HPTLC fingerprints confirmed the presence of signature compounds according to pharmacopeia. Polyphenolic acids and flavonoids in the test drugs have been quantified by HPLC. BS showed maximum inhibitory action on DPPH (2,2-diphenyl-1-picrylhydrazyl) radicals, nitric oxide and superoxide scavenging than other two test drugs, while, PA have highest hydrogen peroxide scavenging action. In diuretic activity, maximum urination occurred in BS group than other two test drugs BV and PA. The highest excretion of sodium–potassium ratio was noted in PA groups followed by BS and BV. BV showed maximum efficacy in crystal formation in test tubes followed by BS and PA.

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