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Siahaan Andre Marolop Pangihutan,Susanto Martin,Lumbanraja Sarma Nursani,Ritonga Dwi Herawati 대한소아청소년과학회 2023 Clinical and Experimental Pediatrics (CEP) Vol.66 No.1
Background: Myelomeningocele is a lifelong condition that features several comorbidities, such as hydrocephalus, scoliosis, club foot, and lower limb sensory and motor disabilities. Its management has progressed over time, ranging from supportive care to early postnatal closure to prenatal closure of the defect. Recent research discovered that fetal myelomeningocele closure (fMMC) provided superior neurological outcomes to those of postnatal closure. When performed at 12 months of age, fMMC can avert or delay the need for a ventriculoperitoneal shunt and reversed the hindbrain herniation. Moreover, fMMC reportedly enhanced motor function and mental development at 30 months of age. However, its long-term outcomes remain dubious.Purpose: This systematic review aimed to determine the long-term neurological cognitive, behavioral, functional, and quality of life (QoL) outcomes after fMMC.Methods: The PubMed, Directory of Open Access Journals, EBSCO, and Cochrane databases were extensively searched for articles published in 2007–2022. Meta-analyses, clinical trials, and randomized controlled trials with at least 5 years of follow-up were given priority.Results: A total of 11 studies were included. Most studies revealed enhanced long-term cognitive, behavioral, functional, and QoL outcomes after fMMC.Conclusion: Our results suggest that fMMC substantially enhanced patients’ long-term neurological cognitive, behavioral, functional, and QoL outcomes.
A Critical Analysis of Intracranial Hemorrhage as a Fatal Complication of Dengue Fever
Andre Marolop Pangihutan Siahaan,Steven Tandean,Bahagia Willibrordus Maria Nainggolan,Junita Tarigan,Johan Samuel Sitanggang 대한신경외과학회 2023 Journal of Korean neurosurgical society Vol.66 No.5
Dengue fever is the most rapidly spreading mosquito-borne virus in the world, infecting about 100 million individuals. A rare but possibly dangerous consequence of dengue illness is intracranial hemorrhage (ICH). Currently, the pathogenesis of ICH is unknown. A number of studies have found a variety of risk factors for ICH in dengue. In addition, studies have reported the use of emergency surgery while monitoring thrombocytopenia in the therapy of dengue ICH. This review enumerates the potential predictors of ICH in dengue, discusses the use of brain imaging, and mentions the possibility of emergency surgery.