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Ganiyu Oboh,Ayokunle O. Ademosun,Margareth Akinleye,Olasunkanmi S. Omojokun,Aline A. Boligon,Margareth L. Athayde 한국식품연구원 2015 Journal of Ethnic Foods Vol.2 No.2
Background: Studies have supported the protective effect of high fruit consumption in the management of chronic diseases such as diabetes. Methods: Thirteen fresh tropical fruits were sourced for and the fruits juices were extracted, freeze dried, and then reconstituted for analysis. The sugar, starch, amylose, and amylopectin contents as well as glycemic indices, antioxidant properties, and the ability of the fruits to inhibit starch-hydrolyzing enzymes were determined. Also, the phenolic constituents of the fruits were characterized using highperformance liquid chromatography coupled with diode array detector. Results: The starch, sugar, amylase, and amylopectin contents were 3.01-3.89 g/100 g, 35.34-60.91 g/ 100 g, 0.84-1.46 g/100 g, and 1.68-2.86 g/100 g, respectively, while the glycemic indices were 28.01 e68.34, with African star apple (28.01) having the lowest and watermelon (68.34) the highest. Furthermore, the fruits exhibited high antioxidant properties as exemplified by their DPPH, ABTS+, OH, and NO radical scavenging abilities. Likewise, the fruits also demonstrated a-amylase and a-glucosidase inhibitory property with Soursop (IC50 = 18.52 mg/mL), guava (IC50 = 19.77 mg/mL), and African star apple (IC50 = 20.86 mg/mL) showing the highest inhibitory potential among the 13 fruits. Similarly, the same trend was followed for a-glucosidase inhibitory activity. Conclusion: The fruits' low glycemic indices, strong antioxidant properties, and inhibition of a-amylase and a-glucosidase activities could be possible mechanisms for their use in the management and prevention of type-2 diabetes.
Sidiqat A. Shodehinde,Ganiyu Oboh,Sunday I. Oyeleye,Tosin A. Olasehinde,Adeniyi A. Adebayo,Aline A. Boligon 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.1
Lasianthera africana is a dark green leafy vegetable commonly consumed as food and used for treatment of several human ailments in Nigeria most especially south-east. This study investigated the phenolic composition and effects of methanol extract from L. africana leaves on enzymes linked to type-2 diabetes (α-amylase and α-glucosidase) and hypertension [angiotensin-1-converting enzymes (ACE)] as well as Fe2+-induced lipid peroxidation in rat’s pancreas and kidney homogenates were evaluated. Phenolic contents and constituents were also determined using colorimetric methods and high performance liquid chromatography-diode array detector (HPLC-DAD) respectively. Our findings revealed that the extract inhibited α-amylase, α-glucosidase and ACE activities with IC50 values of 0.192 and 0.21 mg/mL, and 57.06 μg/mL respectively. The extract also inhibited Fe2+-induced lipid peroxidation in rats’ pancreas and kidney homogenates. Our findings revealed that the extract is rich in phenolic acids such as caffeic acid (59.97 mg/g), chlorogenic acid (58.23 mg/g) and ellagic acid (31.16 mg/g) as well as flavonoids such as quercetin (42.98 mg/g). These results give a clue to the potential use of L. africana leaves as an alternative agent for the control of glucose absorption and lowering of blood pressure in diabetic patients with hypertension.
Adedayo O. Ademiluyi,Ganiyu Oboh,Oluwaseun J. Agbebi,Aline A. Boligon,Margareth L. Athayde 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.12
This study sought to determine the protective effect of dietary inclusion of sorghum leaf sheath dye on cisplatin-induced hepatotoxicity and oxidative stress in rats. Adult male rats were randomly divided into four groups with six animals in each group. Groups I and II were fed a basal diet, while groups III and IV were fed diets containing 0.5% and 1% sorghum leaf sheath dye, respectively, for 20 days before cisplatin administration. Hepatotoxicity was induced by a single dose of cisplatin (7 mg/kg body weight, i.p.), and the experiment was terminated at 3 days after cisplatin injection. The liver and plasma were studied for hepatotoxicity and antioxidant capacity. Cisplatin caused a significant (P < .05) alteration in plasma and liver enzymatic (catalase, glutathione-S-transferase [GST], and superoxide dismutase [SOD]) and nonenzymatic (glutathione [GSH] and vitamin C) antioxidant indices with a concomitant increase in the malondialdehyde (MDA) content; however, there was a significant (P < .05) restoration of the antioxidant status coupled with a significant (P < .05) decrease in the tissue MDA content, after consumption of diets containing sorghum leaf sheath dye. Furthermore, dietary inclusion of sorghum leaf sheath dye caused a marked reduction in the activities of alanine aminotransferase and aspartate aminotransferase after cisplatin administration. However, the ability of the dye to prevent significant cisplatin-induced alteration of both plasma and liver antioxidant indices suggests an antioxidant mechanism of action. Hence, this protective effect of Sorghum bicolor leaf sheath dye against cisplatin-induced hepatotoxicity in rats reflects its potential and beneficial role in the prevention of liver damage associated with cisplatin administration.