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- 저자 : Ali Shao (검색결과 2 건)
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Ali Shao,Gang Chen,Nan Jiang,Ye Li,Xiao Zhang,Lu Wen,Fan Yang,Shaoyang Wei 대한약학회 2013 Archives of Pharmacal Research Vol.36 No.8
The aim of this study was to develop andcharacterize a self-microemulsifying drug delivery system(SMEDDS) of Brucea javanica oil (BJO) and transform theliquid formulation into solid granules. Solubility studies ofBJO and pseudo-ternary phase diagrams were used toidentify the most efficient self-emulsification region. Amethyl thiazolyl tetrazolium (MTT) assay was performedto identify cell apoptosis. Antitumor activity studies werealso employed to evaluate the BJO SMEDDS. The optimizedBJO SMEDDS in liquid and granule formulationsrapidly formed fine oil-in-water microemulsions with particlesizes\50 nm. Additionally, the MTT assay demonstratedthat BJO SMEDDS had a significant effect oncancer cells, and antitumor activity studies showedremarkable inhibition of S180 tumors. The BJO SMEDDS,optimized to have good characteristics, was successfullytransformed into solid granules by adsorbing onto crospovidone. The studies of the release of the BJO SMEDDS ofliquid and granules in vitro suggested that the release ofBJO was enhanced by the SMEDDS. These studiesrevealed that the new self-microemulsifying systems ofliquid and granule forms might be promising strategies forthe oral delivery of the poorly water-soluble drug BJO.
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( Wan-zhu Jiang ),( Fang-jie Yao ),( Ming Fang ),( Li-xin Lu ),( You-min Zhang ),( Peng Wang ),( Jing-jing Meng ),( Jia Lu ),( Xiao-xu Ma ),( Qi He ),( Kai-sheng Shao ),( Asif Ali Khan ),( Yun-hui Wei 한국균학회 2021 Mycobiology Vol.49 No.4
Gloeostereum incarnatum has edible and medicinal value and was first cultivated and domesticated in China. We sequenced the G. incarnatum monokaryotic strain GiC-126 on an Illumina HiSeq X Ten system and obtained a 34.52-Mb genome assembly sequence that encoded 16,895 predicted genes. We combined the GiC-126 genome with the published genome of G. incarnatum strain CCMJ2665 to construct a genetic linkage map (GiC-126 genome) that had 10 linkage groups (LGs), and the 15 assembly sequences of CCMJ2665 were integrated into 8 LGs. We identified 1912 simple sequence repeat (SSR) loci and detected 700 genes containing 768 SSRs in the genome; 65 and 100 of them were annotated with gene ontology (GO) terms and KEGG pathways, respectively. Carbohydrate-active enzymes (CAZymes) were identified in 20 fungal genomes and annotated; among them, 144 CAZymes were annotated in the GiC-126 genome. The A mating-type locus (MAT-A) of G. incarnatum was located on scaffold885 at 38.9 cM of LG1 and was flanked by two homeodomain (HD1) genes, mip and beta-fg. Fourteen segregation distortion markers were detected in the genetic linkage map, all of which were skewed toward the parent GiC-126. They formed three segregation distortion regions (SDR1-SDR3), and 22 predictive genes were found in scaffold1920 where three segregation distortion markers were located in SDR1. In this study, we corrected and updated the genomic information of G. incarnatum. Our results will provide a theoretical basis for fine gene mapping, functional gene cloning, and genetic breeding the follow-up of G. incarnatum.
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