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RISS 인기검색어
- 검색키워드
- 저자 : Ali Mahdavinezhad (검색결과 2 건)
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Ali Mahdavinezhad,Reza Yadegarazari,Seyed Habibollah Mousavi-Bahar,Jalal Poorolajal,Mohammad Jafari,Mohammad Ali Amirzargar,Hosein Effatpanah,Massoud Saidijam 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.2
Purpose: The fifth most common cancer is allocated to bladder cancer (BC) worldwide. Understanding the molecular mechanisms of BC invasion and metastasis to identify target therapeutic strategies will improve disease survival. So the aim of this study was to measure expression rate of zinc finger E-box binding homeobox 1 (ZEB1) and transforming growth factor-beta2 (TGF-β2) mRNA in tissue samples of patients with BC and its healthy adjacent tissue samples and their association with muscle invasion, size and grade of the tumor. Materials and Methods: Tissue samples were collected from 35 newly diagnosed untreated patients with BC from 2013 to 2014. Total RNA was extracted from about 50-mg tissue samples using TRIzol reagent. TAKARA SYBR Premix EX Tag II was applied to determine the rate of mRNA expression by real-time polymerase chain reaction (PCR). To obtain final validation, PCR product of ZEB1 and TGF-β2 were sequenced. STATA 11 software was used to analyze the data. Results: The expression level of ZEB1 in tumor samples was significantly more than of in healthy adjacent tissue samples. Up-regulation of TGF-β2 showed a strong association with muscle invasion (p=0.017). There was also demonstrated a relationship between over expression of ZEB1 with the tumor size (p=0.050). Conclusions: It looks ZEB1 and TGF-β2 had a role in BC patients. In this study ZEB1 expression was higher in BC tissues than that of in healthy control tissues. There was demonstrated a markedly association between overexpression of TGF-β2 and muscle invasion. Therefore, they are supposed to be candidate as potential biomarkers for early detection and progression of BC.
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Lumbosacral Sagittal Alignment in Association to Intervertebral Disc Diseases
Zohreh Habibi,Farid Maleki,Ali Tayebi Meybodi,Ali Mahdavinezhad,Hooshang Saberi 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.6
Study Design: A cross-sectional case-control study was designed to compare the sagittal alignment of lumbosacral regions in two groups of patients suffering from low back pain, one with intervertebral disc pathologies and one without. Purpose: To evaluate the correlation between lumbosacral sagittal alignment and disc degeneration. Overview of Literature: Changes in lumbar lordosis and pelvic parameters in degenerative disc lesions have been assessed in few studies. Overall, patients with discopathy were shown to have lower lumbar lordosis and more vertical sacral profiles. Methods: From patients with intractable low back pain undergoing lumbosacral magnetic resonance imaging, 50 subjects with disc degeneration and 50 controls with normal scans were consecutively enrolled. A method was defined with anterior tangent-lines going through anterior bodies of L1 and S1 to measure global lumbosacral angle, incorporating both lumbar lordosis and sacral slope. Global lumbosacral angle using the proposed method and lumbar lordosis using Cobb’s method were measured in both groups. Results: Lumbar lordosis based on Cobb’s method was lower in group with discopathy (20°–67°; mean, 40.48°±9.89°) than control group (30°–62°; mean, 44.96°±7.68°), although it was not statistically significant. The proposed global lumbosacral angle in subject group (53°–103°; mean, 76.5°±11.018°) was less than control group (52°–101°; mean, 80.18°±9.95°), with the difference being statistically significant (p =0.002). Conclusions: Patients with intervertebral disc lesions seem to have more straightened lumbosacral profiles, but it has not been proven which comes first: disc degeneration or changes in sagittal alignment. Finding an answer to this dilemma demands more comprehensive long-term prospective studies.
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