Protective Effects of β-Carotene Against Ammonium Sulfate Toxicity: Biochemical and Histopathological Approach in Mice Model

Ali Acar,Emine Yalcin,Kultigin Cavusoglu 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.11

In this study, the protective role of β-carotene against ammonium sulfate-induced toxicity has been evaluated in Mus musculus var. albino mice, along with biochemical and histopathological parameters. Some biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), creatinine and oxidative stress parameters, malondialdehyde (MDA), and glutathione (GSH) levels in kidney and liver tissues were investigated. The mice were randomly divided into six groups. Group I received intraperitoneal injections of 0.9% NaCl; group II received orally administered 250 mg kg−1 bw β-carotene, group III received orally administered 500 mg kg−1 bw β-carotene; group IV received 320 mg kg−1 bw ammonium sulfate; group V was given 250 mg kg−1 bw β-carotene +320 mg kg−1 of bw ammonium sulfate; and group VI received orally administered 500 mg kg−1 of bw β-carotene +320 mg kg−1 of bw ammonium sulfate. As a result, it was determined that the ammonium sulfate treatment causes significant changes in the biochemical and oxidative stress parameters and also in histological examinations. In group IV, significant increases in ALT, AST, BUN, MDA, and creatinine levels, and a significant decrease in GSH levels were observed compared with control group. In histopathological examinations, different pathological findings such as proteinaceous deposits, thickening of basement membrane, hyaline cast in kidney tissue and stellate cell, karyomegaly, and binucleated cells in liver tissue were observed. β-carotene treatment in group V and VI ameliorated the elevated levels of liver enzymes and improved oxidative stress and histopathological findings, and so, it could be concluded that β-carotene offered remarkable protection against ammonium sulfate-induced toxicity.

A Comparison of Models for Predicting Discretionary Accruals: A Cross-Country Analysis

ACAR, Goksel,COSKUN, Ali Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9

In this study, we examined various aspects of discretionary accruals. We compared the power of Jones Model (JM), Modified Jones Model (MJM) and Performance Matched Model (PMM). Furthermore, we tested whether accruals derived from cash flow approach or balance sheet approach provide better results and we investigated the significance of country and industry control variables in models. In order to perform these tests, we constructed thirty equations. The data consists of 319 non-financial companies over five years in the GCC region. We used panel data regression models, and testing suggests us to use random effect model as the most suitable one. The results show that PMM has the highest explanatory power among models and it is followed by JM and MJM, consecutively. Secondly, results reveal that accruals derived from cash flow approach provide more accurate results. Moreover, country dummies are significant in models with cash flow approach and they lose significance in balance sheet approach. We differentiated industries due to two different classifications: the first group with higher number of industries is more precise compared to the second group with a narrower scope and lower number of industries. The model including both industrial and country-wise dummies scores highest in significance.

Prevalence of Daytime Urinary Incontinence and Related Risk Factors in Primary School Children in Turkey

Deniz Bolat,Ismail Cenk Acar,Ali Ersin Zumrutbas,Saadettin Eskicorapci,Eyup Burak Sancak,Mehmet Zencir,Tahir Turan,Zafer Sinik 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.3

Purpose: Urinary incontinence is one of the major urinary symptoms in children andadolescents and can lead to major distress for the affected children and their parents. In accordance with the definitions of the Standardization Committee of theInternational Children’s Continence Society, daytime urinary incontinence (DUI) isuncontrollable leakage of urine during the day. The aim of this cross-sectional studywas to investigate the prevalence and associated risk factors of DUI in Turkish primaryschool children. Materials and Methods: The questionnaire, which covered sociodemographic variablesand the voiding habits of the children, was completed by the parents of 2,353 childrenwho were attending primary school in Denizli, a developing city of Turkey. The children’svoiding habits were evaluated by use of the Dysfunctional Voiding andIncontinence Symptoms Score, which is a validated questionnaire. Children with a historyof neurological or urological diseases were excluded. Results: The participation rate was 91.9% (2,164 people). The overall prevalence of DUIwas 8.0%. The incidence of DUI tended to decrease with increasing age and was notsignificantly different between genders (boys, 8.8%; girls, 7.3%; p=0.062). Age, maternaleducation level, family history of daytime wetting, settlement (urban/rural), historyof constipation, urinary tract infection, and urgency were independent risk factors ofDUI. Conclusions: Our findings showed that DUI is a common health problem in primaryschool children. In an effort to increase awareness of children’s voiding problems andthe risk factors for urinary dysfunction in the population, educational programs andlarger school-based screening should be carried out, especially in regions with low socioeconomic status.

An Innovative Universal Screw Removal Instrument

Mehmet Elmadağ,Yunus Güzel,Gökçer Uzer,Mehmet Ali Acar 대한척추신경외과학회 2015 Neurospine Vol.12 No.1

Objective: To present the clinical benefits of an instrument designed to facilitate removal of polyaxial screws during revision surgery. Methods: All polyaxial screws can be removed without additional materials or a large amount of debridement using our newly designed instrument. Forty-two screws were removed from five patients without any complications using this instrument. Results: We removed the cap screws and rods from the 42 polyaxial screws in five patients and made them monoaxial using the new screw removal apparatus. The screws and rods were removed quickly in a minimally invasive way with no complications. No damage to the pedicle or surrounding soft tissue occurred during screw removal. No neurogenic changes developed during revision surgery after changing the screws. Conclusion: This newly designed screw removal instrument was used safely and effectively to remove all polyaxial and monoaxial pedicle screws.

Fetal and maternal outcomes of segmental uterine resection in emergency and planned placenta percreta deliveries

Şükran Doğru,Fatih Akkuş,Aslı Altinordu Atci,Ülfet Sena Metin,Mehmet Uyar,Ali Acar 대한산부인과학회 2024 Obstetrics & Gynecology Science Vol.67 No.1

Objective This study evaluated maternal and fetal outcomes of emergency uterine resection versus planned segmental uterine resection in patients with placenta percreta (PPC) and placenta previa (PP). Methods Patients with PP and PPC who underwent planned or emergency segmental uterine resection were included in this study. Demographic data, hemorrhagic morbidities, intra- and postoperative complications, length of hospital stay, surgical duration, and peri- and neonatal morbidities were compared. Results A total of 141 PPC and PP cases were included in this study. Twenty-five patients (17.73%) underwent emergency uterine resection, while 116 (82.27%) underwent planned segmental uterine resections. The postoperative hemoglobin changes, operation times, total blood transfusion, bladder injury, and length of hospital stay did not differ significantly between groups (P=0.7, P=0.6, P=0.9, P=0.9, and P=0.2, respectively). Fetal weights, 5-minute Apgar scores, and neonatal intensive care unit admission rates did not differ significantly between groups. The gestational age at delivery of patients presenting with bleeding was lower than that of patients who were admitted in active labor and underwent elective surgery (32 weeks [95% confidence interval [CI], 26-37] vs. 35 weeks [95% CI, 34-35]; P=0.037). Conclusion Using a multidisciplinary approach, this study performed at a tertiary center showed that maternal and fetal morbidity and mortality did not differ significantly between emergency versus planned segmental uterine resection.