Evaluation of Anterior Segment Parameter Changes Using the Sirius after Uneventful Phacoemulsification

Ali Şimşek,Musa Çapkın,Şemsettin Bilak,Mete Güler,Ali Hakim Reyhan,Burak Bilgin 대한안과학회 2016 Korean Journal of Ophthalmology Vol.30 No.4

Purpose: To investigate changes in anterior chamber depth (ACD), corneal volume (CV), anterior chamber angle(ACA), anterior chamber volume (ACV), central corneal thickness (CCT), horizontal visible iris diameter (HVID),pupil diameter (PD), and intraocular pressure (IOP) after uneventful phacoemulsification cataract surgery withintraocular lens implantation. Methods: A total of 132 eyes of 132 patients (87 men and 45 women) that underwent uneventful phacoemulsificationcataract surgery and intraocular lens implantation were prospectively studied. The mean age of thepatients was 63.68 ± 12.51 years. All patients were evaluated preoperatively and at 1 month postoperativelywith the Sirius 3D Rotating Scheimpflug camera topography system. The ACD, CV, ACA, ACV, CCT, HVID,and PD measurements were recorded. IOP was measured using the Goldmann applanation tonometer, whichwas corrected for CCT of the Sirius device using Ehlers’ formula. Results: The preoperative mean ACD, ACV, ACA, CCT, CV, PD, HVID, and IOP were 2.79 ± 0.45 mm, 124.73 ±25.72 mm3, 42.09 ± 7.490, 523.87 ± 41.97 microns, 55.37 ± 4.89 mm3, 3.98 ± 1.23 mm, 11.72 ± 0.67 mm, and14.74 ± 2.59 mmHg, respectively. Three months postoperatively, the mean ACD, ACV, ACA, CCT, CV, PD,HVID, and IOP were 3.45 ± 0.6 mm, 162.52 ± 23.79 mm3, 51.46 ± 5.630, 526.21 ± 44.45 microns, 56.23 ± 5.12mm3, 2.87 ± 0.45 mm, 11.91 ± 0.75 mm, and 12.02 ± 1.83 mmHg, respectively. There was a statistically significantincrease in mean postoperative ACD, ACV, ACA, CV, and HVID compared with the corresponding preoperativevalues (p < 0.05). CCT remained stable after surgery. Postoperative PD and IOP were significantlydecreased compared to corresponding preoperative values (p < 0.05). Conclusions: Preoperative measurements by the Sirius 3D Rotating Scheimpflug camera topography systemmight help surgeons to predict postoperative changes resulting from phacoemulsification and intraocular lensimplantation. This is a noncontact, noninvasive, and comfortable system for patients that is highly reliable andrepeatable for anterior segment measurements.

Pomegranate Seed Extract Attenuates Chemotherapy-Induced Acute Nephrotoxicity and Hepatotoxicity in Rats

Kerim Çayır,Ali Karadeniz,Nejdet Şimşek,Serap Yıldırım,Emre Karakuş,Adem Kara,Hürrem Turan Akkoyun,Emin Şengül 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10

Cisplatin (CDDP), one of the most active cytotoxic agents against cancer, has adverse side effects, such as nephrotoxicity and hepatotoxicity. The present study was designed to investigate the potential protective effect of pomegranate seed extract (PSE) against oxidative stress caused by CDDP injury of the kidneys and liver by measuring tissue biochemical and antioxidant variables and immunohistochemically testing caspase-3–positive cells. Twenty-four Sprague–Dawley rats were divided into 4 groups: control; CDDP: injected intraperitoneally with CDDP (7 mg/kg body weight, single dose); PSE: treated for 15 consecutive days by gavage with PSE (300 mg/kg per day); and PSE+CDDP: treated by gavage with PSE 15 days after a single injection of CDDP. The degree of protection against CDDP injury afforded by PSE was evaluated by determining the levels of malondialdehyde as a measure of lipid peroxidation. The levels of glutathione and activities of glutathione peroxidase, glutathione S-transferase, and superoxide dismutase were estimated from liver and kidney homogenates; the liver and kidney were also histologically examined. PSE elicited a significant protective effect toward liver and kidney by decreasing the level of lipid peroxidation; elevating the levels of glutathione S-transferase; and increasing the activities of glutathione peroxidase, glutathione S-transferase, and superoxide dismutase. These biochemical observations were supported by immunohistochemical findings and suggested that PSE significantly attenuated nephrotoxicity and hepatotoxicity by the way of its antioxidant, radical-scavenging, and antiapoptotic effects. This PSE extract could be used as a dietary supplement in patients receiving chemotherapy medications.

Assessment of Patient Pain Experience during Intravitreal 27-Gauge Bevacizumab and 30-Gauge Ranibizumab Injection

Mete Güler,Burak Bilgin,Musa Çapkın,Ali Şimşek,Şemsettin Bilak 대한안과학회 2015 Korean Journal of Ophthalmology Vol.29 No.3

Purpose: To compare pain scores of patients during intravitreal 27-gauge bevacizumab and 30-gauge ranibizumab injection procedures. Methods: Seventy eyes of 70 patients who had not previously undergone intravitreal anti-vascular endothelial growth factor therapy were included in this study. Thirty-five patients received ranibizumab and 35 patients received bevacizumab. The diagnoses of the patients were: 27 age related macular degeneration, 15 diabetic macular edema, 9 diabetic vitreous hemorrhage, 6 central retinal vein occlusion, 11 branch retinal vein occlusion and 2 central serous chorioretinopathy. Bevacizumab (1.25 mg/0.05 mL) was injected into the vitreous cavity using a 27-gauge needle, and ranibizumab (0.5 mg/0.05 mL) was injected with 30-gauge needle. Patients were asked just after the injection to rate their perceived pain during the injection using the visual analogue scale (VAS) of 0 (no pain) to 10 (unbearable/ worst pain). The average of these scores was used as the primary outcome. Results: The VAS pain scores in the ranibizumab and bevacizumab groups were 1.06 ± 0.91 (range, 0 to 3) and 1.94 ± 1.55 (range, 0 to 7), respectively, a significant difference (p = 0.005). Patients <65 and ≥65 years of age in both the ranibizumab and bevacizumab groups were then compared. For patients <65, there was a significant difference in the average VAS pain scores between groups (p = 0.003). However, for patients ≥65 years, there was not a significant difference in the average VAS pain scores between groups (p = 0.238). Female and male patients in both ranibizumab and bevacizumab groups were also compared. For female patients, there was a significant difference in the average VAS pain scores between groups (p = 0.016), although not for male patients (p = 0.078). Conclusions: Thirty-gauge intravitreal injection is more comfortable than 27-gauge injection. Injection of bevacizumab with 30-gauge needle syringes may be more tolerable for patients.

Effects of Trimetazidine on T Wave Alternans in Stable Coronary Artery Disease

Mehmet Yaman,Uğur Arslan,Hasan Ali Gümrükçüoğlu,Musa Şahin,Hakkı Şimşek,Serkan Akdağ 대한심장학회 2016 Korean Circulation Journal Vol.46 No.3

Background and Objectives: Studies reveal that the microvolt T wave alternans (MTWA) test has a high negative predictive value forarrhythmic mortality among patients with ischemic or non-ischemic cardiomyopathy. In this study, we investigate the effects oftrimetazidine treatment on MTWA and several echocardiographic parameters in patients with stable coronary artery disease. Subjects and Methods: One hundred patients (23 females, mean age 55.6±9.2 years) with stable ischemic heart disease were included inthe study group. Twenty-five age- and sex-matched patients with stable coronary artery disease formed the control group. All patientswere stable with medical treatment, and had no active complaints. Trimetazidine, 60 mg/day, was added to their current treatment for aminimum three months in the study group and the control group received no additional treatment. Pre- and post-treatment MTWAvalues were measured by 24 hour Holter testing. Left ventricular systolic and diastolic functions were assessed by echocardiography. Results: After trimetazidine treatment, several echocardiographic parameters related with diastolic dysfunction significantly improved. MTWA has been found to be significantly improved after trimethazidine treatment (63±8 μV vs. 53±7 μV, p<0.001). Abnormal MTWA waspresent in 29 and 11 patients pre- and post-treatment, respectively (p< 0.001). Conclusion: Trimetazidine improves MTWA, a non-invasive determinant of electrical instability. Moreover, several echocardiographic parametersrelated with left ventricular functions also improved. Thus, we can conclude that trimetazidine may be an effective agent to prevent arrhythmiccomplications and improve myocardial functions in patients with stable coronary artery disease.

Comparing the precision of panoramic radiography and cone-beam computed tomography in avoiding anatomical structures critical to dental implant surgery: A retrospective study

Öznur Özalp,Hüseyin Alican Tezerişener,Burak Kocabalkan,Ulviye Şebnem Büyükkaplan,Mehmet Mustafa Özarslan,Göksel Şimşek Kaya,Mehmet Ali Altay,Alper Sindel 대한영상치의학회 2018 Imaging Science in Dentistry Vol.48 No.4

Purpose: The aim of this study was to evaluate the correlations between measurements made using panoramic radiography and cone-beam computed tomography (CBCT) based on certain anatomical landmarks of the jaws, with the goal of preventing complications due to inaccurate measurements in the pre-surgical planning phase of dental implant placement. Materials and Methods: A total of 56 individuals who underwent panoramic radiography and a CBCT evaluation before dental implant surgery were enrolled in the study. Measurements were performed to identify the shortest vertical distance between the alveolar crest and neighboring anatomical structures, including the maxillary sinus, nasal floor, mandibular canal, and foramen mentale. The differences between the measurements on panoramic radiography and CBCT images were statistically analyzed. Results: Statistically significant differences were observed between the measurements on panoramic radiography and CBCT for all anatomical structures (P<.05). The correlation coefficients (r) between the paired samples obtained from panoramic radiography and CBCT were closely correlated (P<.05), with r values varying from 0.921 and 0.979 for different anatomical regions. Conclusion: The results of this study support the idea that panoramic radiography might provide sufficient information on bone height for preoperative implant planning in routine cases or when CBCT is unavailable. However, an additional CBCT evaluation might be helpful in cases where a safety margin cannot be respected due to insufficient bone height.