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We show that roots of log-concave Alexander knot polynomials are dense in C. This in particular implies that the log-concavity and Hoste's conjecture on the Alexander polynomial of alternating knots are (essentially) independent.
Levada,Kateryna,Pshenichnikov,Stanislav,Omelyanchik,Alexander,Rodionova,Valeria,Nikitin,Aleksey,Savchenko,Alexander,Schetinin,Igor,Zhukov,Dmitry,Abakumov,Maxim,Majouga,Alexander,Lunova,Mariia,Jirsa,Mi 나노기술연구협의회 2020 Nano Convergence Vol.7 No.17
Iron oxide nanoparticles (IONs) are frequently used in various biomedical applications, in particular as magnetic resonance imaging contrast agents in liver imaging. Indeed, number of IONs have been withdrawn due to their poor clinical performance. Yet comprehensive understanding of their interactions with hepatocytes remains relatively limited. Here we investigated how iron oxide nanocubes (IO-cubes) and clusters of nanocubes (IO-clusters) affect distinct human hepatic cell lines. The viability of HepG2, Huh7 and Alexander cells was concentration-dependently decreased after exposure to either IO-cubes or IO-clusters. We found similar cytotoxicity levels in three cell lines triggered by both nanoparticle formulations. Our data indicate that different expression levels of Bcl-2 predispose cell death signaling mediated by nanoparticles. Both nanoparticles induced rather apoptosis than autophagy in HepG2. Contrary, IO-cubes and IO-clusters trigger distinct cell death signaling events in Alexander and Huh7 cells. Our data clarifies the mechanism by which cubic nanoparticles induce autophagic flux and the mechanism of subsequent toxicity. These findings imply that the cytotoxicity of ION-based contrast agents should be carefully considered, particularly in patients with liver diseases.
We show that roots of log-concave Alexander knot polyno- mials are dense in C. This in particular implies that the log-concavity and Hoste's conjecture on the Alexander polynomial of alternating knots are (essentially) independent.
This project is dedicated to the elaboration of a man-machine system for monitoring the non spread of nuclear weapons, technologies, raw materials. The main purpose of such a system depends on the customer requirements and may be : - control of non proliferation of nuclear technologies, especially those that can be used to manufacture a nuclear explosive device; - the appraisal of the possibility of production of nuclear weapons by a certain country on the basic of its intellectual and scientific-technical potential, its raw material resources, its export-import potential and other parameters.
The safety and efficiency of nuclear reactors largely depend on the monitoring and control of nuclear radiation. Due to the unique nuclear-physical characteristics, Hf is one of the most promising materials for the manufacturing of the control rods and the emitters of neutron detectors. It is proposed to use the Compton neutron detector with the emitter made of Hf in the In-core Instrumentation System (ICIS) for monitoring the neutron field. The main advantages of such a detector in comparison the conventional β-emission sensors are the possibility of reaching of a higher cumulative radiation dose and the absence of signal delays. The response time of the detection is extremely important when a nuclear reactor is operating near its critical operational parameters. Taking Hf as an example, the general principles for calculating the chains of materials transformation under neutron irradiation are reported. The influence of <sup>179m1</sup>Hf on the Hf composition changing dynamics and the process of transmutants' (Ta, W) generation were determined. The effect of these processes on the absorbing properties of Hf, which inevitably predetermine the lifetime of the detector and its ability to generate a signal, is estimated.
The composition, structure, and distribution of flora and fauna on hydraulic facilities in the cooling system of the Vladivostok combined heat and power plant-2 were studied in summer and autumn of 2001. Cluster analysis was applied to differentiate Balanus rostratus, Mytilus trossulus, Jassa marmorata,Crassostrea gigas + Balanus rostratus, Modiolus modiolus + Pachycheles stevensii, Hydroides ezoensis, and Amphibalanus improvisus communities. The groups of fouling organisms found on the studied objects were shown to be assigned both to “physically controlled” and “biologically balanced” benthic communities. This study stresses the high similarity between the fouling communities of anthropogenic substrata and natural intertidal and subtidal benthic communities from adjacent areas of Peter the Great Bay.
This erratum is being published to correct the printing error on pages 82 and 88 of the article entitled ‘Evaluation of the Impact of Automated Specimen Inoculation, Using Previ Isola, on the Quality of and Technical Time for Stool Cultures' by Alexander Mischnik, Marlies Trampe, and Stefan Zimmermann in Ann Lab Med 2015;35:82-8, DOI 10.3343/alm.2015.35.1.82 as follows.
Alexander,Kretschmer,Alexander,Buchner,Benedikt,Leitl,Markus,Grabbert,Anne,Sommer,Wael,Khoder,Christian,Gozzi,Christian,G.,Stief,Ricarda,M.,Bauer 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.4
Purpose: To evaluate long-term outcomes of AdVance and AdVanceXP male slings in patients with persistent stress urinary incontinence (SUI) after transurethral resection of the prostate (TURP). Methods: A total of 18 consecutive patients received AdVance (n=14) or AdVanceXP (n=4) male sling implantation between 2007 and 2013. Continence was determined by pad use, 24-hour pad testing and validated questionnaires (International Consultation on Incontinence Questionnaire Short Form, ICIQ-SF). Quality of life was evaluated by International Quality of Life (IQoL) score. Patient satisfaction was measured with patient's global impression of improvement score. Cure was defined as 0–5 g in the 24-hour pad test. Statistical analysis included Fisher exact and Wilcoxon test (P<0.05). Results: Follow-up was available for 15 patients who underwent further analysis. After a median follow-up of 70 months (range, 18–83 months), mean daily pad usage was 1.8±2.1 pads (P=0.015 vs. baseline level). Mean IQoL score was 66.4±31.6 (P=0.050 vs. baseline level), and mean ICIQ-SF score was 9.5±6.6 (P=0.077 vs. baseline level). Based on 24-hour pad testing, mean daily urine loss was 31.2±64.5 g (median, 0 g; range, 0–209 g). Cure rate was 46.7%, and cure-and-improved rate was 60.0%. Assessing predictive features for success, better results were found in patients who needed up to 4 pads preoperatively (P=0.041) as well as for patients ≤71 years at the time of implantation (P=0.041). Conclusions: The findings indicate that AdVance and AdVanceXP implantation can be performed effectively and safely in men suffering from SUI after TURP. However, long-term success rates seem to be lower compared to SUI after radical prostatectomy and patients should be counseled accordingly.
The concept of a new method, the CARBEX (CARBonate EXtraction) process, was proposed for reprocessing of spent uranium oxide fuel. The proposed process is based on use of water solutions of Na2CO3 or (NH4)2CO3 and solvent extraction (SE) by the quaternary ammonium compounds for selective recovery and purification of U from the fission products (FPs). Applying of SE allows to reach high degree of purification of U from FPs. Carrying out the processes in poorly aggressive alkaline carbonate media leads to increasing safety of SNF's reprocessing and better selectivity of separation of lanthanides and actinides. Moreover carbonate reprocessing media allows to carry out a recycling and regeneration of reagents. We have been done laboratory scale experiments on the extraction components of simulated voloxidated spent fuel in the solutions of NaOH or Na2CO3–H2O2 and recovery of U from carbonate solutions by SE method using carbonate of methyltrioctylammonium in toluene. It was shown that the purification factors of U from impurities of simulated FPs reached values 103–105. The received results support our opinion that CARBEX after the further development can become more safe, simple and profitable method of spent fuel reprocessing.