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Tiago Felipe Senes-Lopes,Jorge Alberto Lo´pez,Viviane Souza do Amaral,Jose´ Branda˜o-Neto,Adriana Augusto de Rezende,Jefferson Roma´ryo Duarte da Luz,Zaira da Rosa Guterres,Maria das Grac¸as Almeida 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.4
Medicinal plants have been used in primary healthcare since the earliest days of humankind. Turnera subulata and Spondias mombin × Spondias tuberosa are widely used in the Brazilian Northeast to treat several diseases. The aim of this study was to evaluate the genotoxic effects of the leaf extracts of these species by the somatic mutation and recombination test in the somatic cells of Drosophila melanogaster wings. The experiments were performed using standard and high-bioactivation cross and three concentrations of the test substance [aqueous extract (AET and AES) at 5.0, 10.0, and 20.0 mg/mL and ethanolic extract (EET and EES) and ethyl acetate fraction (EAFT and EAFS) at 0.625, 1.25, and 2.5 mg/mL]. Results indicated that the extracts and fractions induced spontaneous frequencies of mutant spots in both D. melanogaster crosses. Nevertheless, the highest concentrations of the tested plant chemical agents were responsible for the statistically significant genotypic effect. T. subulata and S. mombin × S. tuberosa displayed genotoxic effect under the experimental conditions. The results from this study are crucial as they indicated the deleterious and side effects, considering the indiscriminate use of the extracts of these plants for disease treatment.
Valentı´n Flores-Paya´n,Enrique J. Herrera-Lo´ pez,Javier Navarro-Laboulais,Alberto Lo´ pez-Lo´ pez 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
A computational model for a reactor used in advanced water treatment was proposed to represent,simulate and predict the mass transfer process of ozone in water (gas–liquid). A graphic interface wasdesigned to simulate the ozone gas transfer into the liquid. In addition, the values of the mass transfercoefficient, and the self-decomposition of ozone, could be determined for different initial conditions. Themodel for ozone mass transfer was represented by two differential equations derived from the massbalances of the system. Finally a sensitivity analysis wasmade to determine the effect of the parametersover the operating variables.