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Mohanam Anand,Muthukaruppan Alagar,Vaithialingam Selvaraj 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.4
A novel series of various 2-allylbenzo[d]isoxazol-3(2H)-ones were synthesized using benzo[d]isoxazol-3(2H)-one treated with different allyl bromides/chlorides in the presence of water-mediated cesium carbonate as a newcatalyst 3(a-h). The structures of the newly synthesized Benzisoxazole-substituted-allyl derivatives were characterizedby spectroscopic methods and mass spectrometry. These synthesized compounds were evaluated for their in vitro antioxidantand anticancer activity. Compounds 3b, d, f, h were identified as the best hit against HT-29 Human colon cancercells. Similarly, compounds like 3b, d, f, h showed significant antioxidant activity compared to the standard drug butylatedhydroxy toluene (BHT).
Mari Vinoba,정순관,Margandan Bhagiyalakshmi,Muthukaruppan Alagar 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.12
Mesoporous SBA-15 was synthesized using tetraethylorthosilicate (TEOS) as the silica source and Pluronic (P123) as the structure-directing agent. The defective Si-OH groups present in SBA-15 were successively grafted with 3-chloropropyltrimethoxysilane (CPTMS) followed by tris-(2-aminoethyl) amine (TAEA) and/or tetraethylenepentamine (TEPA) for effective immobilization of silver nanoparticles. Grafting of TAEA and/or TEPA amine and immobilization of silver nanoparticles inside the channels of SBA-15 was verified by XRD, TEM, IR and BET techniques. The silver nanoparticles immobilized on TAEA and /or TEPA grafted SBA-15 was subjected for electrocatalytic reduction of hydrogen peroxide (H2O2). The TEPA stabilized silver nanoparticles show higher efficiency for reduction of H2O2 than that of TAEA,due to higher number of secondary amine groups present in TEPA. The amperometric analysis indicated that both the Ag/SBA-15/TAEA and Ag/SBA-15/TEPA modified electrodes required lower over-potential and hence possess high sensitivity towards the detection of H2O2. The reduction peak currents were linearly related to hydrogen peroxide concentration in the range between 3 × 10‒4 M and 2.5 × 10‒3 M with correlation coefficient of 0.997 and detection limit was 3 × 10‒4 M.
Vinoba, Mari,Jeong, Soon-Kwan,Bhagiyalakshmi, Margandan,Alagar, Muthukaruppan Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.12
Mesoporous SBA-15 was synthesized using tetraethylorthosilicate (TEOS) as the silica source and Pluronic (P123) as the structure-directing agent. The defective Si-OH groups present in SBA-15 were successively grafted with 3-chloropropyltrimethoxysilane (CPTMS) followed by tris-(2-aminoethyl) amine (TAEA) and/or tetraethylenepentamine (TEPA) for effective immobilization of silver nanoparticles. Grafting of TAEA and/or TEPA amine and immobilization of silver nanoparticles inside the channels of SBA-15 was verified by XRD, TEM, IR and BET techniques. The silver nanoparticles immobilized on TAEA and /or TEPA grafted SBA-15 was subjected for electrocatalytic reduction of hydrogen peroxide ($H_2O_2$). The TEPA stabilized silver nanoparticles show higher efficiency for reduction of $H_2O_2$ than that of TAEA, due to higher number of secondary amine groups present in TEPA. The amperometric analysis indicated that both the Ag/SBA-15/TAEA and Ag/SBA-15/TEPA modified electrodes required lower over-potential and hence possess high sensitivity towards the detection of $H_2O_2$. The reduction peak currents were linearly related to hydrogen peroxide concentration in the range between $3{\times}10^{-4}\;M$ and $2.5{\times}10^{-3}\;M$ with correlation coefficient of 0.997 and detection limit was $3{\times}10^{-4}\;M$.
Lacidipine self-nanoemulsifying drug delivery system for the enhancement of oral bioavailability
Natesan Subramanian,Shanmugam Palaniappan Sharavanan,Ponnusamy Chandrasekar,Alagar Balakumar,Satya Priya Moulik 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.4
Low bioavailability of Lacidipine (LD), ancalcium channel blocker pose many challenges in thetreatment of hypertension. The objective of this study wasto formulate and characterize LD self-nanoemulsifyingdrug delivery systems (SNEDDS) to improve oralbioavailability of the drug. Formulations were evaluatedfor globule size, surface morphology, emulsification time,cloud point, drug content, in vitro dissolution, ex vivopermeation, stability and oral bioavailability studies. Captex810D, TPGS, Tween-60, Transcutol P and PEG 400was selected based on the solubility study results. Theoptimized SNEDDS readily gets nanoemulsified at 37 Cwith droplet size of 41 nm when mixed with 200 times ofits water. Transmission electron microscope photographsconfirmed the spherical shape of the globules. In vitrodissolution of SNEDDS showed more than 80 % of drugrelease within 15 min. The ex vivo permeation of LD fromSNEDDS is 4.8- and 9-fold higher compared to pure drugin the absence and presence of verapamil respectively. Thestability study of the SNEDDS confirmed no environmentaleffect on the physical nature and drug content. Oralbioavailability of SNEDDS is 2.5 times higher than marketedtablet. The results suggest that, the SNEDDS formulationcan be used as a possible alternative for thetraditional oral formulations of LD to improve its oralbioavailability.
Vengatesan, M. R.,Shen, Tian-Zi,Alagar, M.,Song, Jang-Kun American Scientific Publishers 2016 Journal of nanoscience and nanotechnology Vol.16 No.1
<P>We report a cost effective and easy chemical reduction method for exfoliated individual graphene oxide (GO) and GO paper using p-toluene sulfonic acid (PTSA) under mild conditions. Raman spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), X-ray photon spectroscopy (XPS), thermo gravimetric analysis (TGA) and transmission electron microscopy (TEM) analysis were performed to investigate the quality of GO reduction. Data resulting from the spectral analysis suggest that the reduction method using PTSA is an efficient method to remove oxygen functionalities in the GO and also as an alternative to commonly used reducing agents. We also fabricated chemically reduced GO (RGO) film from GO film using this method. The RGO film exhibits an electrical conductivity of about 10587 Sm-1. These results suggest that this method is very useful for the reduction of GO and GO film or paper using PTSA in a solution process for flexible electronics due to its facile, efficient and cost-effective features.</P>
Surface Plasmon Enhanced Photoluminescence of Rhodamine B Confined in SBA15
K. Dinakaran,A. Chandramohan,M. R. Venkatesan,S. Devaraj,V. Devi,M. Alagar 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.11
Rhodamine B dye (RB) has been introduced into the mesoporous silica (SBA15) and Ag anchored mesoporous silica by applying solution impregnation method. Surface treatment of SBA15 with 3-aminopropyltrimethoxysilane (APTMS) facilitates selective anchoring of the RB molecules on SBA15. The photoluminescence spectra of RB confined within SBA15 indicates higher emission intensity, than that of the RB solid, particularly in the presence of Ag nanoparticles. The significant enhancement in photoluminescence intensity is attributed to the local enhancement of the optical fields near the molecules by interactions with silver plasmons.