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Oda, Akira,Katayose, Yu,Yabuuchi, Shinichi,Yamamoto, Kuniharu,Mizuma, Masamichi,Shirasou, Satoru,Onogawa, Toru,Ohtsuka, Hideo,Yoshida, Hiroshi,Hayashi, Hiroki,Rikiyama, Toshiki,Kim, Hyunjung,Choe, You Potamitis Press 2009 Anticancer research Vol.29 No.4
<P>Circadian rhythms are the daily oscillations of multiple biological processes regulated by an endogenous clock. The Period2 gene is essential in controlling the circadian rhythm and plays an important role in tumor suppression. We examined whether the overexpression of the mouse Period2 gene (mPer2) in cultured tumor cells from human tissues inhibits cell growth, using the recombinant adenovirus vector AdmPer2. The overexpression of mPer2 in human pancreatic cancer cells (Panc1, Aspc1) reduced cellular proliferation and induced apoptotic cell death. Infection with AdmPer2 also inhibited cell-cycle progression, inducing arrest at the G(2)-M phase. Western blotting analyses confirmed that infection with AdmPer2 reduced Bcl-X(L), Cdc2 and cyclin B1 protein, whereas it increased Bax protein in Aspc1 cells. The overexpression of mPer2 suppressed Cdc2 kinase activity. Moreover, infection with AdmPer2 resulted in dose-dependent synergic cell killing effects with the anticancer agent cisplatin (CDDP) in human pancreatic cancer cells. This synergic effect might be related to the reduction of Bcl-X(L) induced by infection with AdmPer2. Our results suggest that the circadian gene Period2 may play an important role in suppression of cell proliferation in human cancer, and additionally Period2 gene expression level may influence the sensitivity to cisplatin depending on Bcl-X(L) expression level.</P>
Nonlinear Receding Horizon Control of a Tandem Cold Millin Acceleration and Deceleration Conditions
Kohei Ozaki,Toshiyuki Ohtsuka,Kenji Fujimoto,Akira Kitamura,Makishi Nakayama 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
For precise control of tension and thickness in a tandem cold millinac celeration and deceleration conditions, we employ an onlin ear model in cluding the rolling speed as a time-varying parameter. It is demon strated in simulation results that nonlinear receding horizon control by realtime optimization achieves satisfactory performance for the nonlinear model.