Spirallike and Robertson Functions of Complex Order with Bounded Boundary Rotations

Ahuja, Om,Cetinkaya, Asena,Kahramaner, Yasemin Department of Mathematics 2019 Kyungpook mathematical journal Vol.59 No.2

Using the concept of bounded boundary rotation, we investigate various properties of two new generalized classes of spirallike and Robertson functions of complex order with bounded boundary rotations.

Variability in Management Practices and Surgical Decision Making in Spinal Tuberculosis: An Expert Survey-Based Study

Ahuja Kaustubh,Gupta Tushar,Ifthekar Syed,Mittal Samarth,Yadav Gagandeep,Kandwal Pankaj 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.1

Study Design: Electronic survey–based study.Purpose: The aim of the study was to objectively review the variability in the prevailing treatment protocols and surgical decision making in the management of patients with spinal tuberculosis (TB) among spine surgeons with expertise in spinal TB across the country.Overview of Literature: A lack of good-quality evidence, ambiguities in the national spinal TB guidelines, and the demand for early rehabilitation and a better quality of life in patients with spinal TB has led to the emergence of various gray zones in the management of spinal TB.Methods: Seventeen fellowship-trained spinal TB experts representing different geographical regions of India completed an online survey consisting of questions pertaining to the conservative management of spinal TB (antitubercular therapy) and 30 clinical case vignettes including a wide spectrum of presentations of spinal TB with no or minimal neurological deficit. The variability in the responses for questions and case wise variability with respect to surgical decision making was assessed using the index of qualitative variation (IQV). The average tendency to operate (TTO) was calculated for various groups of respondents.Results: High variability was observed in all questions regarding conservative spinal TB management (IQV > 0.8). Among the 30 case vignettes, 14 were found to have high variability with respect to surgical decision making (IQV > 0.8). With respect to levels of fixation, all but two cases had poor or slight agreement. Younger age and practice in a government or tertiary care teaching hospital were factors associated with a higher TTO.Conclusions: Significant variability was detected in treatment practices for the management of spinal TB among experts. Most of the case vignettes were found to have significant heterogeneity with respect to surgical decision making, which reflects a significant lack of consensus and lacunae in literature.

Multivalent Harmonic Uniformly Starlike Functions

Ahuja, Om,Joshi, Santosh,Sangle, Naveneet Department of Mathematics 2009 Kyungpook mathematical journal Vol.49 No.3

In this paper, we investigate a generalized family of complex-valued harmonic functions that are multivalent, sense-preserving, and are associated with k-uniformly harmonic functions in the unit disk. The results obtained here include a number of known and new results as their special cases.

ON THE RADIUS PROBLEM OF CERTAIN ANALYTIC FUNCTIONS

Ahuja, O.P. Korean Mathematical Society 1985 대한수학회보 Vol.22 No.1

MEROMORPHIC CLOSE-TO-STAR FUNCTIONS

AHUJA, O.P.,MOGRA, M.L. Korean Mathematical Society 1983 대한수학회지 Vol.20 No.1

Functional role of ginseng-derived compounds in cancer

Ahuja, Akash,Kim, Ji Hye,Kim, Jong-Hoon,Yi, Young-Su,Cho, Jae Youl The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3

Ginseng is a natural product best known for its curative properties in diverse physiological processes such as cancer, neurodegenerative disorders, hypertension, and maintenance of hemostasis in the immune system. In previous decades, there have been some promising studies into the pharmacology and chemistry of ginseng components and the relationship between their structure and function. The emerging use of modified ginseng and development of new compounds from ginseng for clinical studies have been topics of study for many researchers. The present review deals with the anticancer, anti-inflammatory, antioxidant, and chemopreventive effects, and recent advances in microRNA technology related to red ginseng. The review also summarizes the current knowledge on the effect of ginsenosides in the treatment of cancer.

Ethnopharmacological properties of <i>Artemisia asiatica</i>: A comprehensive review

Ahuja, Akash,Yi, Young-Su,Kim, Mi-Yeon,Cho, Jae Youl Elsevier 2018 Journal of Ethnopharmacology Vol.220 No.-

<P><B>Abstract</B></P> <P><B>Ethnopharmacological relevance</B></P> <P> <I>Artemisia asiatica</I> Nakai (Compositae) has a long history as a traditional remedy. Preparation from various parts of the plant (aerial parts and leaves) are used to treat a wide range of diseases including gastric trouble, liver dysfunction, and skin inflammation.</P> <P><B>Aims of this review</B></P> <P>The aims of this review were: 1) to provide an overview of recent studies and progress on <I>A. asiatica</I>-derived ethnopharmacological compounds and their pharmacological activities; and 2) to summarize existing evidence and provide insight for future studies.</P> <P><B>Materials and methods</B></P> <P>This investigation was carried out by analyzing published books and research papers <I>via</I> scientific databases, namely Science Direct, PubMed ACS Publication, Wiley Online Library, CNKI and information obtained online. The keywords “<I>Artemisia asiatica</I> traditional uses,” “Compounds isolated and studied in <I>Artemisia asiatica,</I>” and “Pharmacological advances in <I>Artemisia asiatica</I>” were used and articles published between 1995 and 2017 were considered. In total, 500 works related to biological activities of <I>A. asiatica</I> were identified, and only materials published in English were included in the review.</P> <P><B>Results</B></P> <P>Comparative analysis of literature searched through sources available confirmed that the ethnopharmacological use of <I>A. asiatica</I> was recorded in Korea, China, and Japan. Phytochemical studies revealed the presence of flavonoids, sesquiterpene lactones, monoterpenes, and steroids in <I>A. asiatica</I>. Of these, flavonoids have been shown to exhibit significant pharmacological effects such as gastroprotective, anti-inflammatory, anti-tumor, and anti-microbial actions.</P> <P><B>Conclusions</B></P> <P>Phytochemical and pharmacological studies of <I>Artemisia asiatica</I> have proven that this plant is one of valuable medicinal sources with neuroprotective, gastroprotective, anti-oxidative, anti-inflammatory, and anti-cancer effects. Although ethanol extract of this plant is now being prescribed as gastroprotective and anti-ulcerative medicine, it is now time to expand its application to other human inflammatory diseases such as pancreatitis and hepatitis and further extensive study on toxicity in human. Therefore, the present review will encourage further studies of <I>A. asiatica</I> in the pursuit of wide range of therapeutic remedy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

UPPER BOUNDS OF SECOND HANKEL DETERMINANT FOR UNIVERSALLY PRESTARLIKE FUNCTIONS

Ahuja, Om,Kasthuri, Murugesan,Murugusundaramoorthy, Gangadharan,Vijaya, Kaliappan Korean Mathematical Society 2018 대한수학회지 Vol.55 No.5

In [12,13] the researchers introduced universally convex, universally starlike and universally prestarlike functions in the slit domain ${\mathbb{C}}{\backslash}[1,{\infty})$. These papers extended the corresponding notions from the unit disc to other discs and half-planes containing the origin. In this paper, we introduce universally prestarlike generalized functions of order ${\alpha}$ with ${\alpha}{\leq}1$ and we obtain upper bounds of the second Hankel determinant ${\mid}a_2a_4-a^2_3{\mid}$ for such functions.

Analyzing the interaction of RseA and RseB, the two negative regulators of the sigmaE envelope stress response, using a combined bioinformatic and experimental strategy.

Ahuja, Nidhi,Korkin, Dmitry,Chaba, Rachna,Cezairliyan, Brent O,Sauer, Robert T,Kim, Kyeong Kyu,Gross, Carol A American Society for Biochemistry and Molecular Bi 2009 The Journal of biological chemistry Vol.284 No.8

<P>The Escherichia coli envelope stress response is controlled by the alternative sigma factor, sigma(E), and is induced when unfolded outer membrane proteins accumulate in the periplasm. The response is initiated by sequential cleavage of the membrane-spanning antisigma factor, RseA. RseB is an important negative regulator of envelope stress response that exerts its negative effects onsigma(E) activity through its binding to RseA. In this study, we analyze the interaction between RseA and RseB. We found that tight binding of RseB to RseA required intact RseB. Using programs that performed global and local sequence alignment of RseB and RseA, we found regions of high similarity and performed alanine substitution mutagenesis to test the hypothesis that these regions were functionally important. This protocol is based on the hypothesis that functionally dependent regions of two proteins co-evolve and therefore are likely to be sequentially conserved. This procedure allowed us to identify both an N-terminal and C-terminal region in RseB important for binding to RseA. We extensively analyzed the C-terminal region, which aligns with a region of RseA coincident with the major RseB binding determinant in RseA. Both allele-specific suppression analysis and cysteine-mediated disulfide bond formation indicated that this C-terminal region of similarity of RseA and RseB identifies a contact site between the two proteins. We suggest a similar protocol can be successfully applied to pairs of non-homologous but functionally linked proteins to find specific regions of the protein sequences that are important for establishing functional linkage.</P>

A SPECIAL SUBCLASS OF CLOSE TO CONVEX FUNCTIONS

AHUJA, O.P. Korean Mathematical Society 1983 대한수학회지 Vol.20 No.2