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        The relationship between metabolic syndrome and its components with bladder cancer: a systematic review and meta-analysis of cohort studies

        Ahmadinezhad Mozhgan,Arshadi Maedeh,Hesari Elahe,Sharafoddin Maedeh,Azizi Hosein,Khodamoradi Farzad 한국역학회 2022 Epidemiology and Health Vol.44 No.-

        A previous meta-analysis, entitled “The association between metabolic syndrome and bladder cancer susceptibility and prognosis: an updated comprehensive evidence synthesis of 95 observational studies involving 97,795,299 subjects,” focused on all observational studies, whereas in the present meta-analysis, we focused on cohort studies to obtain more accurate and stronger evidence to evaluate the association between metabolic syndrome and its components with bladder cancer. PubMed, Embase, Scopus, and Web of Science were searched to identify studies on the association between metabolic syndrome and its components with bladder cancer from January 1, 2000 through May 23, 2021. The pooled relative risk (RR) and 95% confidence intervals (CI) were used to measure this relationship using a random-effects meta-analytic model. Quality appraisal was undertaken using the Newcastle-Ottawa Scale. In total, 56 studies were included. A statistically significant relationship was found between metabolic syndrome and bladder cancer 1.09 (95% CI, 1.02 to 1.17), and there was evidence of moderate heterogeneity among these studies. Our findings also indicated statistically significant relationships between diabetes (RR, 1.23; 95% CI, 1.16 to 1.31) and hypertension (RR, 1.07; 95% CI, 1.01 to 1.13) with bladder cancer, but obesity and overweight did not present a statistically significant relationship with bladder cancer. We found no evidence of publication bias. Our analysis demonstrated statistically significant relationships between metabolic syndrome and the risk of bladder cancer. Furthermore, diabetes and hypertension were associated with the risk of bladder cancer.

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        The prevalence of Q fever in the Eastern Mediterranean region: a systematic review and meta-analysis

        Ahmadinezhad Mozhgan,mounesan leila,Doostiirani Amin,Yousefi Behzadi Manijeh 한국역학회 2022 Epidemiology and Health Vol.44 No.-

        OBJECTIVES: Q fever is a main zoonotic disease around the world. This disease is common in the Eastern Mediterranean region, so we conducted for the first time a systematic review and meta-analysis between humans and animals and ticks in the Eastern Mediterranean region. METHODS: Major national and international databases were searched from 2000 up to 2021. We extracted the prevalence of Q fever in a blood sample in animal, milk sample in animal, tick, and human as the main outcome. We reported the prevalence of seropositivity and molecular positivity as point and 95% confidence intervals. RESULTS: In this review, 112 papers were identified. The overall seroprevalence Q fever was 22.4% (95% CI 19.8–25.1). The pooled prevalence of Q fever in tick was 17.5% (95% CI -1.3-36.4). The prevalence was 25.5%( 95% CI 16.1-34.9) in human. The prevalence of Q fever in animal blood samples such as goat, sheep, camel, cattle, dog, cat, buffalo, and horse were 28.1%, 25.1%, 25.0%, 20.1%, 8.4%, 9.8%, 6.3%, and 6.5%, respectively. Also, the prevalence of Q fever in milk samples of animals was higher in cattle 20.3% than sheep 20.0%, goat 16.4%, and camel 3.3%. CONCLUSIONS: C.burnetii infections are common in human and in a wide range of animal species but they are still not recognized in many countries in the Eastern Mediterranean region, thus presenting a significant threat to human and animal health in the region.

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