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RISS 인기검색어
- 검색키워드
- 저자 : Aggarwal Bharat B. (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
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Nuclear Factor - kB Activation : A Question of Life or Death
Shishodia, Shishir,Aggarwal, Bharat B . 생화학분자생물학회 1998 BMB Reports Vol.35 No.1
Apoptosis is a mode of cell death that plays an important role in both pathological and physiological processes. Research during the last decade has delineated the entire machinery needed for cell death, and its constituents were found to pre-exist in cells. The apoptotic cascade is triggered when cells are exposed to an apoptotic stimulus. It has been known for several years that inhibitors of protein synthesis can potentiate apoptosis that is induced by cytokines and other inducers. Until 1996, it was not understood why protein synthesis inhibitors potentiate apoptosis. Then three reports appeared that suggested the role of the transcription factor NF-kB activation in protecting the cells from TNF-induced apoptosis. Since then several proteins have been identified that are regulated by NF-kB and are involved in cell survival, proliferation, and protection from apoptosis. It now seems that when a cell is attacked by an apoptotic stimulus, the cell responds first by activating anti-apoptotic mechanisms, which may or may not be followed by apoptosis. Whether or not a cell undergoes proliferation, the survival, or apoptosis, appears to involve a balance between the two mechanisms. Inhibitors of protein synthesis seem to suppress the appearance of protein that are involved in anti-apoptosis. The present review discusses how NF-kB controls apoptosis.
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Nuclear Factor-κB Activation: A Question of Life or Death
Shishodia, Shishir,Aggarwal, Bharat B. Korean Society for Biochemistry and Molecular Biol 2002 Journal of biochemistry and molecular biology Vol.35 No.1
Apoptosis is a mode of cell death that plays an important role in both pathological and physiological processes. Research during the last decade has delineated the entire machinery needed for cell death, and its constituents were found to pre-exist in cells. The apoptotic cascade is triggered when cells are exposed to an apoptotic stimulus. It has been known for several years that inhibitors of protein synthesis can potentiate apoptosis that is induced by cytokines and other inducers. Until 1996, it was not understood why protein synthesis inhibitors potentiate apoptosis. Then three reports appeared that suggested the role of the transcription factor NF-${\kappa}B$ activation in protecting the cells from TNF-induced apoptosis. Since then several proteins have been identified that are regulated by NF-${\kappa}B$ and are involved in cell survival, proliferation, and protection from apoptosis. It now seems that when a cell is attacked by an apoptotic stimulus, the cell responds first by activating anti-apoptotic mechanisms, which mayor may not be followed by apoptosis. Whether or not a cell undergoes proliferation, the survival, or apoptosis, appears to involve a balance between the two mechanisms. Inhibitors of protein synthesis seem to suppress the appearance of protein that are involved in anti-apoptosis. The present review discusses how NF-${\kappa}B$ controls apoptosis.
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Sahdeo Prasad,Amit K. Tyagi,Bharat B. Aggarwal 대한암학회 2014 Cancer Research and Treatment Vol.46 No.1
Curcumin (diferuloylmethane) is a yellow pigment present in the spice turmeric(Curcuma longa) that has been associated with antioxidant, anti-inflammatory, anticancer,antiviral, and antibacterial activities as indicated by over 6,000 citations. Inaddition, over one hundred clinical studies have been carried out with curcumin. Oneof the major problems with curcumin is perceived to be the bioavailability. Howcurcumin should be delivered in vivo, how bioavailable is it, how well curcumin isabsorbed and how it is metabolized, is the focus of this review. Various formulationsof curcumin that are currently available are also discussed.
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Curcumin, Inflammation, and Neurological disorders: How are they linked?
Garodia Prachi,Hegde Mangala,Kunnumakkara Ajaikumar B.,Aggarwal Bharat B. 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3
Background : Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol majorly found in Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases. Methods : We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using ‘Curcumin and clinical trials’. Results : This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis, and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed. Conclusion : This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of devastating neurological disorders.
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