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Curcumin, Inflammation, and Neurological disorders: How are they linked?
Garodia Prachi,Hegde Mangala,Kunnumakkara Ajaikumar B.,Aggarwal Bharat B. 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3
Background : Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol majorly found in Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases. Methods : We searched PubMed database for relevant publications on curcumin and its uses in treating neurological diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using ‘Curcumin and clinical trials’. Results : This review details the pleiotropic immunomodulatory functions and neuroprotective properties of curcumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), Amyotrophic lateral sclerosis (ALS), brain tumors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis, and traumatic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed. Conclusion : This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of devastating neurological disorders.