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- 저자 : Agdas, Alireza Sadighi (검색결과 4 건)
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Dai, Wensheng,Zand, Yousef,Agdas, Alireza Sadighi,Selmi, Abdellatif,Roco-Videla, Angel,Wakil, Karzan,Issakhov, Alibek Techno-Press 2021 Advances in nano research Vol.10 No.6
Nano batteries are manufactured batteries which use nanoscale technology, small particles measuring less than 100 nanometers or 10-7 meters. In addition, because of plentiful potassium supplies and less cost, potassium-ion batteries (PIBs) are taken as possible substitutes for lithium-ion batteries for massive energy storing systems. Our modern lifestyle could be totally different without rechargeable batteries. Regarding their economic and management usage, these batteries are applied in electric and hybrid vehicles, devices, and renewable power generation systems. Accordingly, regarding the huge K ion radius, it is a difficult process for identifying relevant materials with excellent cycling stability and capacity. At present, the production of suitable anode materials with high specific capacities, long cycle life and low costs for PIBs remains a major challenge. Also, the continuing improvement in defining future electors, the manufacture of PIBs has been complicated by multiple challenges, namely low reversible performance, insufficient cycling stability and poor energy density, all of which have created important doubts for the effective implications of PIBs. Nano-particles have shown various advantages for enhanced energy and power density, cyclability and safety when it comes to designing and producing electrode materials via efficient computer simulation. In combination with large volume expansion, slow reaction kinetics, and low electrical conductivity the main cause for the degradation of SnO<sub>2</sub> reaction reversibility and power decay observed are not as obvious as those of Lithium-ion batteries (LIBs) as anodes of sodium-ion batteries (SIBs), and potassium-ion batteries (KIBs).
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Cai, Ting,Zandi, Yousef,Agdas, Alireza Sadighi,Selmi, Abdellatif,Issakhov, Alibek,Roco-Videla, Angel Techno-Press 2021 Advances in concrete construction Vol.11 No.6
Freeze and thaw phenomena in cold regions are the main cause of severe damage to concrete structures. Alkali-activated slag repair mortars, which are introduced as a suitable material for the replacement of Portland cement, can be used as the protective coating for these damaged structures. The mechanical properties and durability of this coating layer should be studied. In this study, the mechanical properties and durability of alkali-activated slag repair mortars with silica fume (SF) participation as inorganic additives against freeze-thaw and salt scaling attacks have been investigated. In order to evaluate the effects of alkaline activators type, the ratio of these solutions to Pozzolan (Pozz), and the use of SF as a substitute base material, these three factors were considered as the main variables to produce 12 alkali-activated slag mortar mixtures. To investigate their mechanical properties, compressive strength, tensile adhesion strength, and drying shrinkage tests were conducted. Also, mortar specimen length change, compressive strength loss, weight loss, and dynamic elastic modulus were measured to evaluate the durability features against freeze-thaw and salt scaling attacks. According to the results, in addition to higher compressive strength and adhesion resistance of alkali-activated slag repair mortars, these mortars showed at least 30% better durability against freeze-thaw and salt scaling attacks than cement-based repair mortar. Also, alkali-activated slag mixtures containing potassium hydroxide, alkaline solution (AS) to Pozz ratio of 0.7, and SF had the best mechanical properties and frost resistance among all mixtures.
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Yan Cao,Yousef Zandi,Alireza Sadighi Agdas,Qiangfeng Wang,Xueming Qian,Leijie Fu,Karzan Wakil,Abdellatif Selmi,Alibek Issakhov,Angel Roco-Videla 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.39 No.6
This paper is aimed to review the use of artificial intelligence (AI) algorithms in diverse civil engineering applications such as predicting and evaluating the different parameters of composite beams and shear connectors and determining the compressive strength of concrete. Also, the application of AI methods especially artificial neural network (ANN) in construction engineering and management including prediction and estimation, decision-making, classification or selection, optimization and risk analysis and safety has been thoroughly discussed. Furthermore, the integration of Artificial Neural network (ANN) with other soft computing methods, such as Backpropagation (BP), imperialist competitive algorithm (ICA), support vector regression (SVR), back-propagation neural network (BPNN), Genetic Algorithms (GA) and Multilayer feed forward (MLFF) has been reviewed. It has been reported that the combination of ANN with other intelligence algorithms leads to providing more accurate results. Moreover, the performance of ANN with other soft computing techniques, such as BP, BPNN, SVR, GA, ICA, and MLFF in various fields has been compared and ANN in many cases had superiority over other models.
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Sun, Chaoyang,Fang, Yong,Yin, Jun,Chen, Jian,Ju, Zhenlin,Zhang, Dong,Chen, Xiaohua,Vellano, Christopher P.,Jeong, Kang Jin,Ng, Patrick Kwok-Shing,Eterovic, Agda Karina B.,Bhola, Neil H.,Lu, Yiling,Wes American Association for the Advancement of Scienc 2017 Science translational medicine Vol.9 No.392
<P>Mutant <I>RAS</I> has remained recalcitrant to targeted therapy efforts. We demonstrate that combined treatment with poly(adenosine diphosphate–ribose) polymerase (PARP) inhibitors and mitogen-activated protein kinase (MAPK) kinase (MEK) inhibitors evokes unanticipated, synergistic cytotoxic effects in vitro and in vivo in multiple <I>RAS</I> mutant tumor models across tumor lineages where <I>RAS</I> mutations are prevalent. The effects of PARP and MEK inhibitor combinations are independent of <I>BRCA1/2</I> and <I>p53</I> mutation status, suggesting that the synergistic activity is likely to be generalizable. Synergistic activity of PARP and MEK inhibitor combinations in <I>RAS</I> mutant tumors is associated with (i) induction of BIM-mediated apoptosis, (ii) decrease in expression of components of the homologous recombination DNA repair pathway, (iii) decrease in homologous recombination DNA damage repair capacity, (iv) decrease in DNA damage checkpoint activity, (v) increase in PARP inhibitor–induced DNA damage, (vi) decrease in vascularity that could increase PARP inhibitor efficacy by inducing hypoxia, and (vii) elevated PARP1 protein, which increases trapping activity of PARP inhibitors. Mechanistically, enforced expression of FOXO3a, which is a target of the RAS/MAPK pathway, was sufficient to recapitulate the functional consequences of MEK inhibitors including synergy with PARP inhibitors. Thus, the ability of mutant <I>RAS</I> to suppress FOXO3a and its reversal by MEK inhibitors accounts, at least in part, for the synergy of PARP and MEK inhibitors in <I>RAS</I> mutant tumors. The rational combination of PARP and MEK inhibitors warrants clinical investigation in patients with <I>RAS</I> mutant tumors where there are few effective therapeutic options.</P>
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