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New Butyrylcholinesterase Inhibitory Triterpenes from Salvia santolinifolia
Mehmood Sajid,Riaz Naheed,Nawaz Sarfraz Ahmed,Afza Nighat,Malik Abdul,Choudhary Muhammad Iqbal The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.3
Slavins A (1) and B (2), the new amyrin type triterpenes, have been isolated from the chloroform soluble fraction of Salvia santolinifolia and assigned structures on the basis of spectral studies including 2D NMR. Both the compounds displayed inhibitory potential against the enzyme butyrylcholinesterase.
New Butyrylcholinesterase Inhibitory Triterpenes from Salvia santolinifolia
Sajid Mehmood,Naheed Riaz,Sarfraz Ahmed Nawaz,Nighat Afza,Abdul Malik,Muhammad Iqbal Choudhary 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.3
Slavins A (1) and B (2), the new amyrin type triterpenes, have been isolated from the chloroform soluble fraction of Salvia santolinifolia and assigned structures on the basis of spectral studies including 2D NMR. Both the compounds displayed inhibitory potential against the enzyme butyrylcholinesterase.
Ophiamides A-B, New Potent Urease Inhibitory Sphingolipids from Heliotropium ophioglossum
Sadiqa Firdous,Abdul Malik,Nida Hassan Ansari,Itrat Fatima,Nighat Afza,Lubna Iqbal,Mehreen Lateef 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7
Ophiamides A (1) and B (2), two new sphingolipids have been isolated from the n-hexane subfraction of the MeOH extract of the whole plant of Heliotropium ophioglossum along with glycerol monopalmitate (3) and β-sitosterol 3-O-β-D-glucoside (4) reported for the first time from this species. Their structures were elucidated by spectroscopic techniques including MS and 2D-NMR spectroscopy. Both the compounds 1 and 2 showed potent inhibitory activity against the enzyme urease.
Butyrylcholinesterase Inhibitory Guaianolides from Amberboa ramosa
Sher Bahadar Khan,Azhar-ul-Haq,Shagufta Perveen,Nighat Afza,Abdul Malik,Sarfraz Ahmad Nawaz,Muhammad Raza Shah,Muhammad Iqbal Choudhary 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.2
Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as 8α-hydroxy-11β−methyl-1αH, 5αH, 6βH, 7αH, 11αH-guai-10(14), 4(15)-dien-6, 12-olide(1), 3β, 8α-dihydroxy-11α−methyl-1αH, 5αH, 6βH, 7αH, 11βH-guai-10(14), 4 (15)-dien-6, 12-olide (2), 3β, 4α, 8α-trihydroxy-4β-(hydroxymethyl)- 1αH, 5αH, 6βH, 7αH-guai-10(14), 11(13)-dien-6, 12-olide (3), 3β, 4α, 8α-trihydroxy-4β- (chloromethyl)-1αH, 5αH, 6βH, 7αH-guai-10(14),11(13)-dien-6, 12-olide(4), 3β, 4α, dihydroxy- 4β-(hydroxymethyl)-1αH, 5αH, 6βH, 7αH-guai-10(14),11(13)-dien-6, 12-olide(5), 3β, 4α-dihydroxy- 4β- (chloromethyl)-8α-(4-hydroxymethacrylate)-1αH, 5αH, 6βH, 7αH-guai-10(14),11 (13)-dien-6,12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.
Butyrylcholinesterase Inhibitory Guaianolides from Amberboa ramosa
Khan Sher Bahadar,Haq Azhar-ul,Perveen Shagufta,Afza Nighat,Malik Abdul,Nawaz Sarfraz Ahmad,Shah Muhammad Raza,Choudhary Muhammad lqbal The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.2
Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as $8{\alpha}$-hydroxy-$11{\beta}$-methyl-$1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\alpha}H-guai-10(14)$, 4(15)-dien-6, 12-olide(2), $3{\beta},\;8{\alpha}-dihydroxy-11{\alpha}-methyl-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\beta}H-guai-10(14)$, 4(15)-dien-6, 12-olide (2), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide (3), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}-(chloromethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide(4), $3{\beta},\;4{\alpha},\;dihydroxy-4{\beta}-(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide(5), $3{\beta},\;4{\alpha}-dihydroxy-4{\beta}-(chloromethyl)-8{\alpha}-(4-hydroxymethacrylate)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.
New Butyrylcholinesterase Inhibitory Steroid and Peroxy Acid from Leucas urticifolia
Fatima, Itrat,Ahmad, Ijaz,Anis, Itrat,Malik, Abdul,Afza, Nighat,Iqbal, Lubna,Latif, Mehreen 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.8
A new steroid leucisterol (1) and a new peroxy acid urticic acid (2) along with methoxybenzyl benzoate (3), 4-hydroxy benzoic acid (4), $\beta$-sitosterol (5), and ursolic acid (6), have been isolated from the chloroform soluble fraction of the whole plant of Leucas urticifolia. Their structures were elucidated on the basis of nuclear magnetic resonance (1D and 2D NMR) spectral data. Leucisterol showed potent inhibitory activity against butyrylcholinesterase enzyme.
Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia
Sharif, Ahsan,Ahmed, Ejaz,Malik, Abdul,Riaz, Naheed,Afza, Nighat,Nawaz, Sarfraz Ahmad,Arshad, Muhammad,Shah, Muhammad Raza,Chaudhary, Muhammad Iqbal The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.7
Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with $\beta$-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.
Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia
Ahsan Sharif,Ejaz Ahmed,Abdul Malik,Naheed Riaz,Nighat Afza,Sarfraz Ahmad Nawaz,Muhammad Arshad,Muhammad Raza Shah,Muhammad Iqbal Choudhary 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.7
Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with β-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.