http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Adrián Suárez (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Production of high-quality water by reverse osmosis of milk dairy condensates
Adrián Suárez,Francisco A. Riera 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Low-pollution flash cooler (FC) condensates from the direct heat treatment of milk and milk-basedproducts were treated by means of reverse osmosis (RO) in order to obtain high-quality water for use inboilers. The behaviour of the spiral-wound membranes at the pilot-plant scale (8.2m2 surface area) wastested in terms of the permeate flow rate (J) and quality (conductivity and chemical oxygen demand(COD)) as a function of the operation conditions, including the pressure, temperature and volumeconcentration rate (VCR). Response surfaces were drawnwith the aim of obtaining information regardingthe permeate flow rate as well as conductivity and COD reduction in the range of the studied parameters. Based on the experimental data, a plant with a 90% recovery rate (RR)was proposed with the objective ofcarrying out a preliminary economic assessment, which yielded a payback of 1.16 years.
-
Etiopathogenic role of ERK5 signaling in sarcoma: prognostic and therapeutic implications
Sánchez-Fdez Adrián,Matilla-Almazán Sofía,Del Carmen Sofía,Abad Mar,Arconada-Luque Elena,Jiménez-Suárez Jaime,Chinchilla-Tábora Luis Miguel,Ruíz-Hidalgo Mª José,Sánchez-Prieto Ricardo,Pandiella Atanas 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Sarcomas constitute a heterogeneous group of rare and difficult-to-treat tumors that can affect people of all ages, representing one of the most common forms of cancer in childhood and adolescence. Little is known about the molecular entities involved in sarcomagenesis. Therefore, the identification of processes that lead to the development of the disease may uncover novel therapeutic opportunities. Here, we show that the MEK5/ERK5 signaling pathway plays a critical role in the pathogenesis of sarcomas. By developing a mouse model engineered to express a constitutively active form of MEK5, we demonstrate that the exclusive activation of the MEK5/ERK5 pathway can promote sarcomagenesis. Histopathological analyses identified these tumors as undifferentiated pleomorphic sarcomas. Bioinformatic studies revealed that sarcomas are the tumors in which ERK5 is most frequently amplified and overexpressed. Moreover, analysis of the impact of ERK5 protein expression on overall survival in patients diagnosed with different sarcoma types in our local hospital showed a 5-fold decrease in median survival in patients with elevated ERK5 expression compared with those with low expression. Pharmacological and genetic studies revealed that targeting the MEK5/ERK5 pathway drastically affects the proliferation of human sarcoma cells and tumor growth. Interestingly, sarcoma cells with knockout of ERK5 or MEK5 were unable to form tumors when engrafted into mice. Taken together, our results reveal a role of the MEK5/ERK5 pathway in sarcomagenesis and open a new scenario to be considered in the treatment of patients with sarcoma in which the ERK5 pathway is pathophysiologically involved.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
