Hepatotoxicity in an Adolescent with Black Iced Tea Overconsumption

Adamos Hadjipanayis,Elisavet Efstathiou,Vasiliki Papaevangelou 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.4

Tea is the most widely consumed beverage after water in the world. The consumption of iced tea has increased in Western countries and spiked among teenagers for enjoyment, freshening up and alertness. A teenager presented with symptoms of hepatitis. Liver ultrasound revealed sludge in the gallbladder. Laboratory investigations excluded all known causes of hepatotoxicity. Detail nutritional history revealed that the patient had been drinking 1.5–2 liters of black iced tea per day for the last three months. He was immediately advised to stop drinking any tea. Gradually all symptoms disappeared and two months after discontinuation of the tea, all liver enzymes returned to normal and the sludge in the gallbladder disappeared. This case report underlines the importance of a meticulous assessment of a child's dietary behavior when investigating a case of hepatotoxicity and raises awareness about the potential side effects of tea overconsumption.

1LJ-10 Metamaterials Platforms for Hybrid Perovskites

( Girogio Adamo ) 한국공업화학회 2017 한국공업화학회 연구논문 초록집 Vol.2017 No.1

We show that luminescence spectra of solution-processable metalhalide perovskite films can be controlled by nanopatterning, leading to up to five-fold increase of luminescence yield. We engineered the optical response of the perovskite films using metamaterial design concepts and, as proof of principle, we fabricated all-perovskite dielectric metasurfaces and hybrid metal-perovskite metamaterials which show significantly enhanced luminescence emission and controlled spectral response throughout the visible region. The all-dielectric metamaterials were engraved by direct focused ion beam milling (FIB) onto thin films of methylammonium lead iodide perovskite (CH₃NH₃PbI₃) spin-coated on quartz substrate. The perovskite metasurfaces show vivid structural color tuning and strong field enhancement, dependent on the geometrical parameters of the nanometer sized metamolecules. We observed up to a five-fold Purcell enhancement of both photo- and cathodo-luminescence emission compared to the unstructured films. We also discuss hybridization of perovskite films with plasmonic metamaterials and metal-semiconductor-metal slab waveguide geometries to provide higher control on the light extraction properties. Our results prove that nanostructuring and hybridization of perovskites with metamaterials are viable routes to engineer tunable structural colour and radiative emission properties on-demand, thus defining a new paradigm to increase the efficiency, control the electroluminescence spectrum, and improve light extraction and directivity of light-emitting devices.

Hepatotoxicity in an Adolescent with Black Iced Tea Overconsumption

Hadjipanayis, Adamos,Efstathiou, Elisavet,Papaevangelou, Vasiliki The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.4

Tea is the most widely consumed beverage after water in the world. The consumption of iced tea has increased in Western countries and spiked among teenagers for enjoyment, freshening up and alertness. A teenager presented with symptoms of hepatitis. Liver ultrasound revealed sludge in the gallbladder. Laboratory investigations excluded all known causes of hepatotoxicity. Detail nutritional history revealed that the patient had been drinking 1.5-2 liters of black iced tea per day for the last three months. He was immediately advised to stop drinking any tea. Gradually all symptoms disappeared and two months after discontinuation of the tea, all liver enzymes returned to normal and the sludge in the gallbladder disappeared. This case report underlines the importance of a meticulous assessment of a child's dietary behavior when investigating a case of hepatotoxicity and raises awareness about the potential side effects of tea overconsumption.

Participation in a Community-Based Sport Program is Feasible for Children with Congenital Heart Disease and May Benefit Physical Literacy Development: A Pilot Study

Angelica Z. Blais(Angelica Z. Blais ),Jane Lougheed(Jane Lougheed ),Kristi B. Adamo(Kristi B. Adamo ),Patricia E. Longmuir(Patricia E. Longmuir ) 사피엔시아 2020 Exercise Medicine Vol.4 No.-

Objectives: Children with congenital heart disease (CHD) often lack confidence and demonstrate limited movement skills during physical activity. Community-based sport programs have been suggested to build their confidence and competence. This study examined the feasibility and physical literacy impact of an existing community-based sport program for children with moderate to complex CHD. Methods: This pilot study employed a parallel mixed method, single-case experimental design to evaluate the feasibility and impact of a weekly, community-based sport intervention (Sportball©). Intervention field notes and focus group transcripts were analysed deductively to inform feasibility. Physical literacy outcomes were measured using the Canadian Assessment of Physical Literacy. Paired t-tests examined changes in physical literacy scores, while qualitative data informed perceived changes in physical literacy tasks. Results: Participants (n=11, 45% female) were 8.2 ± 1.2 years. Nine children completed >80% of the 1-hour Sportball© sessions (10 lessons total). No adverse events occurred during or as a result of the intervention. Enabling participants to recognize the sensations of exercise and whether or not they needed to rest, designing activities and instructions to mitigate the risk of body contact, and accommodating the needs of participants with developmental/attentional limitations were important factors embedded into the design of the program, contributing to its feasibility. Participants reported perceived improvements in movement skill and torso endurance/strength, changes which were reflected in the objective physical literacy measures (movement skill: Δ mean= 2.0 ± 0.98 points, p=0.07, r=0.57; torso endurance/strength: Δ mean= 5.27 ± 7.20 seconds, p=0.44, r=0.26). Conclusions: The Sportball© intervention was feasible for children with CHD, including those with activity restrictions or developmental delays. Children enjoyed the program and wanted it to continue. Measurable improvements in movement skill and muscular endurance were recognized by participants. Future trials evaluating Sportball©’s impact with larger samples and multiple 10-week sessions are recommended.

Children with Cardiomyopathy have Active Lifestyles Despite Reporting Disease-Specific Barriers to Physical Activity: A Mixed-Methods Study

Kevin Moncion(Kevin Moncion ),Letizia Gardin(Letizia Gardin ),Jane Lougheed(Jane Lougheed ),Kristi Adamo(Kristi Adamo ),Patricia E. Longmuir(Patricia E. Longmuir ) 사피엔시아 2022 Exercise Medicine Vol.6 No.-

Objectives: This exploratory mixed-methods study explored the barriers to physical activity, daily physical activity and submaximal exercise capacity among children with and at risk for cardiomyopathy and children with atrial septal defects. Methods: The study followed a convergent parallel mixed methodology design. Semi-structured interviews explored physical activity barriers. Seven-day accelerometry assessed moderate-to-vigorous physical activity, and an intermittent cardiopulmonary exercise test measured submaximal exercise capacity. Results: Twenty children, including 5 with cardiomyopathy (n=2 females, 14.2 ± 2.7 years old), 7 who were genotype-positive phenotype-negative for cardiomyopathy (n=5 females, 10.6 ± 3.3 years old) and 8 with atrial septal defects (n=4 females, 9.4 ± 3.8 years old) were recruited. Children with cardiomyopathy reported disease-specific physical activity barriers, while children who were genotype-positive phenotype-negative perceived barriers related to lack of time, parent support or activity motivation. The average daily moderate-to-vigorous physical activity was less than the recommended 60-minutes/day (n=20, mean 48.1 ± 18.0 minutes). Children with cardiomyopathy participated a median of 141.2 [interquartile range (IQR): 98.8) minutes of light-intensity physical activity and a median of 55.6 (IQR: 34.6) minutes of moderate-to-vigorous physical activity. The average submaximal exercise capacity was low (n=16, 25.2 ± 5.7 mL/kg/min). Estimated submaximal exercise capacity, including metabolic equivalent (4.5 ± 3.1 METs), respiratory exchange ratio (median = 1.0, IQR: 0.09) and ratings of perceived exertion (median = 7, IQR: 5) at peak exercise suggest that children with cardiomyopathy appear to have the exercise capacity to participate in low-to-moderate intensity activities. Conclusions: These novel data suggest that a diagnosis of cardiomyopathy may not preclude children from participating in a healthy, active lifestyle. However, they perceive disease-specific physical activity barriers and may require support to optimize their level of participation for optimal health.

Biocatalysis and Bioprocess Engineering : Physiological Effects of GLT1 Modulation in Saccharomyces cerevisiae Strains Growing on Different Nitrogen Sources

( Marco Brambilla ),( Giusy Manuela Adamo ),( Gianni Frascotti ),( Danilo Porro ),( Paola Branduardi ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.2

Saccharomyces cerevisiae is one of the most employed cell factories for the production of bioproducts. Although monomeric hexose sugars constitute the preferential carbon source, this yeast can grow on a wide variety of nitrogen sources that are catabolized through central nitrogen metabolism (CNM). To evaluate the effects of internal perturbations on nitrogen utilization, we characterized strains deleted or overexpressed in GLT1, encoding for one of the key enzymes of the CNM node, the glutamate synthase. These strains, together with the parental strain as control, have been cultivated in minimal medium formulated with ammonium sulfate, glutamate, or glutamine as nitrogen source. Growth kinetics, together with the determination of protein content, viability, and reactive oxygen species (ROS) accumulation at the single cell level, revealed that GLT1 modulations do not significantly influence the cellular physiology, whereas the nitrogen source does. As important exceptions, GLT1 deletion negatively affected the scavenging activity of glutamate against ROS accumulation, when cells were treated with H2O2, whereas Glt1p overproduction led to lower viability in glutamine medium. Overall, this confirms the robustness of the CNM node against internal perturbations, but, at the same time, highlights its plasticity in respect to the environment. Considering that side-stream protein-rich waste materials are emerging as substrates to be used in an integrated biorefinery, these results underline the importance of preliminarily evaluating the best nitrogen source not only for media formulation, but also for the overall economics of the process.

STAR CLUSTER PROPERTIES IN TWO LEGUS GALAXIES COMPUTED WITH STOCHASTIC STELLAR POPULATION SYNTHESIS MODELS

Krumholz, Mark R.,Adamo, Angela,Fumagalli, Michele,Wofford, Aida,Calzetti, Daniela,Lee, Janice C.,Whitmore, Bradley C.,Bright, Stacey N.,Grasha, Kathryn,Gouliermis, Dimitrios A.,Kim, Hwihyun,Nair, Pre IOP Publishing 2015 The Astrophysical journal Vol.812 No.2

<P>We investigate a novel Bayesian analysis method, based on the Stochastically Lighting Up Galaxies (slug) code, to derive the masses, ages, and extinctions of star clusters from integrated light photometry. Unlike many analysis methods, slug correctly accounts for incomplete initial mass function (IMF) sampling, and returns full posterior probability distributions rather than simply probability maxima. We apply our technique to 621 visually confirmed clusters in two nearby galaxies, NGC 628 and NGC 7793, that are part of the Legacy Extragalactic UV Survey (LEGUS). LEGUS provides Hubble Space Telescope photometry in the NUV, U, B, V, and I bands. We analyze the sensitivity of the derived cluster properties to choices of prior probability distribution, evolutionary tracks, IMF, metallicity, treatment of nebular emission, and extinction curve. We find that slug's results for individual clusters are insensitive to most of these choices, but that the posterior probability distributions we derive are often quite broad, and sometimes multi-peaked and quite sensitive to the choice of priors. In contrast, the properties of the cluster population as a whole are relatively robust against all of these choices. We also compare our results from slug to those derived with a conventional non-stochastic fitting code, Yggdrasil. We show that slug's stochastic models are generally a better fit to the observations than the deterministic ones used by Yggdrasil. However, the overall properties of the cluster populations recovered by both codes are qualitatively similar.</P>

THE BRIGHTEST YOUNG STAR CLUSTERS IN NGC 5253

Calzetti, D.,Johnson, K. E.,Adamo, A.,Gallagher III, J. S.,Andrews, J. E.,Smith, L. J.,Clayton, G. C.,Lee, J. C.,Sabbi, E.,Ubeda, L.,Kim, H.,Ryon, J. E.,Thilker, D.,Bright, S. N.,Zackrisson, E.,Kennic IOP Publishing 2015 The Astrophysical journal Vol.811 No.2

<P>The nearby dwarf starburst galaxy NGC 5253 hosts a number of young, massive star clusters, the two youngest of which are centrally concentrated and surrounded by thermal radio emission (the 'radio nebula'). To investigate the role of these clusters in the starburst energetics, we combine new and archival Hubble Space Telescope images of NGC 5253 with wavelength coverage from 1500 angstrom 1.9 mu m in 13 filters. These include H alpha, P beta, and P alpha, and the imaging from the Hubble Treasury Program LEGUS (Legacy Extragalactic UV Survey). The extraordinarily well-sampled spectral energy distributions enable modeling with unprecedented accuracy the ages, masses, and extinctions of the nine optically brightest clusters (M-V < -8.8) and the two young radio nebula clusters. The clusters have ages similar to 1-15 Myr and masses similar to 1 x 10(4)-2.5 x 10(5) M-circle dot. The clusters' spatial location and ages indicate that star formation has become more concentrated toward the radio nebula over the last similar to 15 Myr. The most massive cluster is in the radio nebula; with a mass similar to 2.5 x 10(5) M-circle dot and an age similar to 1 Myr, it is 2-4 times less massive and younger than previously estimated. It is within a dust cloud with AV similar to 50 mag, and shows a clear near-IR excess, likely from hot dust. The second radio nebula cluster is also similar to 1 Myr old, confirming the extreme youth of the starburst region. These two clusters account for about half of the ionizing photon rate in the radio nebula, and will eventually supply about 2/3 of the mechanical energy in present-day shocks. Additional sources are required to supply the remaining ionizing radiation, and may include very massive stars.</P>

LEGACY EXTRAGALACTIC UV SURVEY (LEGUS) WITH THE<i>HUBBLE SPACE TELESCOPE</i>. I. SURVEY DESCRIPTION

Calzetti, D.,Lee, J. C.,Sabbi, E.,Adamo, A.,Smith, L. J.,Andrews, J. E.,Ubeda, L.,Bright, S. N.,Thilker, D.,Aloisi, A.,Brown, T. M.,Chandar, R.,Christian, C.,Cignoni, M.,Clayton, G. C.,Silva, R. da,Mi IOP Publishing 2015 The Astronomical journal Vol.149 No.2

“Spermidine restores dysregulated autophagy and polyamine synthesis in aged and osteoarthritic chondrocytes via EP300”

Rosa Maria Borzì,Silvia Cetrullo,Stefania D’Adamo,Manuela Minguzzi,Flavio Flamigni 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-