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- 저자 : Acar Emine (검색결과 3 건)
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Ali Acar,Emine Yalcin,Kultigin Cavusoglu 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.11
In this study, the protective role of β-carotene against ammonium sulfate-induced toxicity has been evaluated in Mus musculus var. albino mice, along with biochemical and histopathological parameters. Some biochemical parameters such as aspartate transaminase (AST), alanine transaminase (ALT), blood urea nitrogen (BUN), creatinine and oxidative stress parameters, malondialdehyde (MDA), and glutathione (GSH) levels in kidney and liver tissues were investigated. The mice were randomly divided into six groups. Group I received intraperitoneal injections of 0.9% NaCl; group II received orally administered 250 mg kg−1 bw β-carotene, group III received orally administered 500 mg kg−1 bw β-carotene; group IV received 320 mg kg−1 bw ammonium sulfate; group V was given 250 mg kg−1 bw β-carotene +320 mg kg−1 of bw ammonium sulfate; and group VI received orally administered 500 mg kg−1 of bw β-carotene +320 mg kg−1 of bw ammonium sulfate. As a result, it was determined that the ammonium sulfate treatment causes significant changes in the biochemical and oxidative stress parameters and also in histological examinations. In group IV, significant increases in ALT, AST, BUN, MDA, and creatinine levels, and a significant decrease in GSH levels were observed compared with control group. In histopathological examinations, different pathological findings such as proteinaceous deposits, thickening of basement membrane, hyaline cast in kidney tissue and stellate cell, karyomegaly, and binucleated cells in liver tissue were observed. β-carotene treatment in group V and VI ameliorated the elevated levels of liver enzymes and improved oxidative stress and histopathological findings, and so, it could be concluded that β-carotene offered remarkable protection against ammonium sulfate-induced toxicity.
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Persistent Reaction to Bacitracin after Patch Testing with Thin Layer Rapid Use Epicutaneous Test
( Belkız Uyar ),( Emine Müge Acar ) 대한피부과학회 2020 Annals of Dermatology Vol.32 No.4
Long-lasting allergic patch test reactions (LLAPTR) are reactions that remain positive for two weeks or more after the application of the allergen. LLAPTR of longer than 6 weeks duration is rarely seen. Here we present a 54-year-old female patient who had a positive allergic reaction to bacitracin with the thin layer rapid use epicutaneous test (TRUE test), which lasted for about 11 weeks duration. To our knowledge this is the first reported case of LLAPTR related to the bacitracin. (Ann Dermatol 32(4) 331∼333, 2020)
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Evaluating Focal 18F-FDG Uptake in Thyroid Gland with Radiomics
Aksu Ayşegül,Karahan Şen Nazlı Pınar,Acar Emine,Çapa Kaya Gamze 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.5
Purpose The aim of this study was to evaluate the ability of 18F-FDG PET/CT texture analysis to predict the exact pathological outcome of thyroid incidentalomas. Methods 18F-FDG PET/CT images between March 2010 and September 2018 were retrospectively reviewed in patients with focal 18F-FDG uptake in the thyroid gland and who underwent fine needle aspiration biopsy from this area. The focal uptake in the thyroid gland was drawn in 3D with 40% SUVmax threshold. Features were extracted from volume of interest (VOI) using the LIFEx package. The features obtained were compared in benign and malignant groups, and statistically significant variables were evaluated by receiver operating curve (ROC) analysis. The correlation between the variables with area under curve (AUC) value over 0.7 was examined; variables with correlation coefficient less than 0.6 were evaluated with machine learning algorithms. Results Sixty patients (70% train set, 30% test set) were included in the study. In univariate analysis, a statistically significant difference was observed in 6 conventional parameters, 5 first-, and 16 second-order features between benign and malignant groups in train set (p < 0.05). The feature with the highest benign-malignant discriminating power was GLRLMRLNU (AUC:0.827). AUC value of SUVmax was calculated as 0.758. GLRLMRLNU and SUVmax were evaluated to build a model to predict the exact pathology outcome. Random forest algorithm showed the best accuracy and AUC (78.6% and 0.849, respectively). Conclusion In the differentiation of benign-malignant thyroid incidentalomas, GLRLMRLNU and SUVmax combination may be more useful than SUVmax to predict the outcome.
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