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Abbas Saadat,AliAsghar Behnamghader,Saeed Karbasi,Daryoush Abedi,Masoud Soleimani,Abbas Shafiee 한국생물공학회 2013 Biotechnology and Bioprocess Engineering Vol.18 No.3
Nanocomposites have recently been identified as a useful scaffolding material in tissue engineering applications. Poly (3-hydroxybutyrate)/hydroxyapatite nanoparticles (P3HB)/(nHA) porous scaffolds were successfully fabricated through a solvent casting and particulate leaching technique. P3HB/nHA and P3HB scaffolds were prepared by the same technique for comparison. The structure of the nanocomposite and P3HB scaffolds was observed by SEM. The Energy Disperssive X-ray Analysis (EDXA, map of Ca)results indicated that HA nanoparticles were homogeneously dispersed in the P3HB matrix. X-ray diffraction (XRD)analysis showed that P3HB and HA coexist in the nanocomposite. Transmission electron microscopy (TEM)images also showed that the particle size of HA was 30 ~40 nm. The porosity of the scaffolds was 84%, and macropores and micropores coexisted and interconnected throughout the scaffolds. Acellular bioactivity experiments showed that more HA crystals formed on the surface of the nanocomposite scaffold than on the P3HB scaffold after 4weeks immersion in Simulated Body Fluid (SBF). Cell culture experiments demonstrated that the P3HB/nHA nanocomposite scaffold had a better tendency of proliferation and Alkaline Phosphatase (ALP) activity to MG 63 cells than the pure P3HB scaffold. It was found that nHA addition can improve acellular and cellular bioactivity of the P3HB scaffold.
Seyyed Mostafa Mirkhalili,Seyyed Abbas Mousavi,Ahmad Ramazani Saadat Abadi,Masoud Sadeghi 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.12
Mesh-reinforced cellulose acetate (CA)-based membranes were prepared for forward osmosis (FO) by immersion precipitation. Casting compositions such as CA percent and 1, 4-dioxane/acetone ratio and also preparation conditions such as evaporation time, coagulation bath and annealing temperatures were tested for membranes’ performance. The results were compared with commercially CTA membranes. The best membrane (17.9% polymer and 1, 4-dioxane/acetone ratio of 1.89) showed water flux of 9.3 L/m2h (LMH) and RSF of 0.536mol NaCl/m2h. Moreover, the membrane structure was reinforced by a polyester mesh, which created micro pores in the back of the membrane. This caused higher water flux and RSF compared to membranes without mesh. FO membrane prepared under best conditions, had a smoother surface than commercial ones. This feature enhances the fouling properties of the membrane, which can be appropriate for wastewater treatment applications.