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- 저자 : AKS Rawat (검색결과 6 건)
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Antimicrobial Studies of Stem of Different Berberis Species
Meenakshi Singh,Sharad Srivastava,AKS Rawat 한국생약학회 2009 Natural Product Sciences Vol.15 No.2
Berberis is an important medicinal plant, of the family Berberidaceae. Different Berberis species and their parts are very common in herbal drug markets of India and world over as an adulterant/substitute to ‘Daruharidra’ i.e. B. aristata DC. Antimicrobial activity of 50% hydroalcoholic extracts of stem of four Berberis species viz. B. aristata DC., B. asiatica Roxb. ex DC., B. chitria Lindl. and B. lycium Royle and the isolated alkaloid berberine were tested against eleven bacterial and eight fungal strains. The extracts with the strongest antibacterial activity was obtained from B. lycium followed by B. aristata, B. asiatica and B. chitria. Based on these results it is possible to conclude that the hydroalcoholic extract and alkaloid (berberine) has stronger and broader spectrum against bacterial strains as compared to fungal strains. The result obtained in the present study authenticates and support the use of these plants in folklore medicine for treatment of various infectious diseases caused by the bacterial pathogens. However, an attempt has been made to explore the possibilities of utilizing stem part rather than roots of these species with the aim to conserve this species which is over exploited due to diverse use of its root. These findings will stimulate the search for novel, natural products as new antibacterial/ antifungal agents which may be useful to pharmaceutical industries.
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Dewan, Abhinav,Sharma, SK,Dewan, AK.,Srivastava, Himanshu,Rawat, Sheh,Kakria, Anjali,Mishra, Maninder,Suresh, T,Mehrotra, Krati Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Objective of the study is to evaluate volumetric and dosimetric alterations taking place during radiotherapy for locally advanced head and neck cancer (LAHNC) and to assess benefit of replanning in them. Materials and Methods: Thirty patients with LAHNC fulfilling the inclusion and exclusion criteria were enrolled in a prospective study. Planning scans were acquired both pre-treatment and after 20 fractions (mid-course) of radiotherapy. Single plan (OPLAN) based on initial CT scan was generated and executed for entire treatment course. Beam configuration of OPLAN was applied to anatomy of interim scan and a hybrid plan (HPLAN30) was generated. Adaptive replanning (RPLAN30) for remaining fractions was done and dose distribution with and without replanning compared for remaining fractions. Results: Substantial shrinkage of target volume (TV) and parotids after 4 weeks of radiotherapy was reported (p<0.05). No significant difference between planned and delivered doses was seen for remaining fractions. Hybrid plans showed increase in delivered dose to spinal cord and parotids for remaining fractions. Interim replanning improved homogeneity of treatment plan and significantly reduced doses to cord (Dmax, D2% and D1%) and ipsilateral parotid (D33%, D50% and D66%) (p<0.05). Conclusions: Use of one or two mid-treatment CT scans and replanning provides greater normal tissue sparing along with improved TV coverage.
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Pharmacognostic Evaluation of Curcuma caesia Roxb. rhizome
Durgesh Verma,,Sharad Srivastava,Vineet Singh,AKS Rawat 한국생약학회 2010 Natural Product Sciences Vol.16 No.2
Curcuma caesia Roxb. (Zingiberaceae) is commonly known as `Black turmeric'. In India it grows in West Bengal, Madhya Pradesh, Orissa, Bihar, North-East and Uttar Pradesh and is widely used by ethnic communities for various ailments. Rhizomes of the plant are used for sprains and bruises and are also employed in cosmetics. In West Bengal it is an important place in traditional system of medicine and is also used as a substitute for turmeric in fresh stage. Present communication deals with the detailed pharmacognostical evaluation of the rhizome sample. Inner part of the rhizome is bluish-black in colour and emits a characteristic sweet smell, due to the presence of essential oil. On steam distillation the rhizome yields an essential oil rich in camphor. A detailed HPTLC studies has been carried out for quantitative evaluation of active marker component. HPTLC, physico-chemical, morphological and histological parameters presented in this paper may be proposed as parameters to establish the authenticity of C. caesia rhizome and may possibly help to differentiate the drug from its other allied species.
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Pharmacognostical Evaluation and Phytochemical Standardization of Abrus precatorius L. Seeds
Durgesh Verma,Shashi Shankar Tiwari,Sharad Srivastava,AKS Rawat 한국생약학회 2011 Natural Product Sciences Vol.17 No.1
The seeds of Abrus precatorius L. (Family- Fabaceae) constitute the drugs Abrus, Gunja, or Ratti in commerce. In the Indian System of Medicine, the seeds are used for sciatica, paralysis, headache, dysentery, diarrhoea, leprosy, ulcer, nervous disorders, alopecia, as well as anti-inflammatory, antidiabetic, antibacterial, antitumor, sexual stimulant and abortifacient. Seeds are poisonous and therefore are used after mitigation. The protein abrin is responsible for the highly toxic properties of seeds. Quantitative HPTLC analysis of the methanolic extract of seeds determined the presence of 0.4018% gallic acid and 0.4009% glycyrrhizin. The present study was undertaken to develop an HPTLC method, as well as ascertain the physico-chemical, morphological and histological parameters to establish the authenticity of A. precatorius seeds.
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Pharmacognostic Evaluation of Pipper longum Linn. Fruit
Manjoosha Srivastava,Meenu Gupta,Sharad Srivastava,Shanta Mehrotra,Vinita Sharma,AKS Rawat 한국생약학회 2007 Natural Product Sciences Vol.13 No.2
present study includes macro and microscopical details, powder study, physico-chemical studyand HPTLC fingerprinting of the Piper longum fruits. Microscopic studies revealed the presence of stone cells,starch grains and thin walled fragments of parenchymatous cells. Physico-chemical studies showed alcohol andether soluble extract 24.53 and 6.7, sugar 0.35, starch 21.33 and tannin 0.83% respectively. Successive soxhletextract showed maximum percentage of hexane soluble fraction i.e. 22.52. The HPTLC profile has also beenperformed against the reference marker piperine, which was identified at Rf 0.42. pharmacognostical evaluation of fruit has been undertaken.KeywordsPiper longum, Pharmacognosy, HPTLC.
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Pharmacognostic Evaluation of Curcuma aeurigenosa Roxb.
Sharad Srivastava,Nitin Chitranshi,Sanjay Srivastava,Mathew Dan,AKS Rawat,Palpu Pushpangadan 한국생약학회 2006 Natural Product Sciences Vol.12 No.3
aeruginosa Roxb. (FamilyZingeberaceae), comonly known as “pink and blue ginger” iscultivated in southern India. The plant is distinguished by red corolla lobes and ferruginous or greenish-bluerhizome. Rhizoma is used medicinally as anti-diarrheal, anti-fungal; external use as astringent for wounds. Adetailed pharmacognostic evaluation of its rhizome showed total ash 6.1%, acid insoluble ash 1.20%, alcoholsoluble extractives 3.70%, water soluble extractives 14.50%, sugar 20.93%, starch 41.85%, and tannins 0.68%.On hydro distillation, the rhizomes and sesile tubers yielded 0.17% oil.KeywordsCurcuma aueriginosa, rhizome, pharmacognosy, standardization
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