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- 검색키워드
- 저자 : A. O. Bakare (검색결과 3 건)
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A. O. Bakare,A. L. Oyewole,B. V. Owoyele 경희대학교 융합한의과학연구소 2019 Oriental Pharmacy and Experimental Medicine Vol.19 No.3
Diverse etiology of neuropathic pain conditions demands new understanding of its pathogenesis and development of efective therapy. Treatment of induced neuropathic pain using aqueous Adansonia digitata bark extract has not been investigated. We probed the systemic administration efects of A. digitata bark extract on sciatic nerve ligated induced neuropathic pain. Treatments with extract caused increased pain threshold on hot plate, hot- and cold-immersion test. Notably, an apparent decreased in systemic prostaglandin E2 occurred concurrently with strengthened oxidative defense system. By contrast, extract-hexamethonium, -propranolol, -atropine or -prazosin cotreatments in induced-neuropathic rats suggested no involvement of muscarinic, nicotinic, beta or alpha-1 receptors in the analgesic action of the extract. Though, a weaken oxidative defense system was observed based on oxidative markers measured. These results indicate the crude extract ability to induce pain relief in neuropathic pain and this coincides with degree of decreased PGE2 and increased antioxidants as well as decreased lipid peroxidation product. This is the frst report demonstrating the usefulness of aqueous A. digitata bark extract in the management of neuropathic pain, an action that involves alteration of PGE2 and oxidative defense system.
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Oyinleye O. E.,Adeniran S. A.,Ogunsuyi O. M.,Oyeyemi I. T.,Bakare A. A. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
Telfairia occidentalis (Hook F.) and Vernonia amygdalina are two commonly consumed vegetables, individually and as recipes, for their nutritive and medicinal values in Africa. Data on reproductive toxicity and DNA damage of the combination of these plants on the male reproductive system is scarce. We evaluated the toxic and genotoxic effects of aqueous extracts of T. occidentalis and V. amygdalina and their combination on the reproductive cells of male Swiss albino mice. Groups of mice exposed to five concentrations (62.5–1000 mg/kg) of each extract or combination as against distilled water and cyclophosphamide (20 mg/kg bwt) as negative and positive control respectively were examined for abnormal sperm morphology, organo-somatic index and pathological changes. Each of the extracts significantly reduced the frequency of aberrant sperm cells, while their combination provoked increasing sperm abnormalities when compared with the negative control. None of the extracts induced adverse effect on body and testes weight of exposed mice. There was no visible histological lesion induced by extracts of V. amygdalina but there were residual bodies indicative of increased spermatogenesis. The extracts of T. occidentalis induced necrosis only at 1000 mg/kg, while with the combination, there were necrotic cells, mild congestion of blood vessels, and the seminiferous tubules had irregular outlines. These indicates that aqueous extracts of T. occidentalis and V. amygdalina individually at the tested doses did not evoke significant induction of genetic damage in the sperm head, and pathological changes unlike the combination in mice.
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Facile and rapid preparation of platinum counter electrodes for dye-sensitized solar cells
Sarker, S.,Seo, H.W.,Bakare, F.O.,Aziz, Md.A.,Kim, D.M. Elsevier Sequoia 2016 Journal of photochemistry and photobiology Chemist Vol. No.
<P>Here, we report on the deposition of platinum nanoparticles (PNPs) on fluorine-doped tin oxide (FTO) substrate by synthesizing PNPs through chemical reduction of potassium tetrachloroplatinate with formic acid, and subsequently depositing the PNPs on FTO substrate at 70 degrees C; and application of the chemically reduced Pt electrodes (CRs) as the counter electrodes (CEs) of dye-sensitized solar cells (DSSCs). The surface morphology and catalytic activity of the prepared CRs were studied along with conventional thermally decomposed Pt electrodes (TDs). Electrochemical study showed that the catalytic performance of the CRs toward the reduction of I-3(-) was comparable to that of TDs. Also, the photovoltaic performance of the DSSCs with CRs were similar to that with TDs. The method of preparing Pt electrodes through chemical reduction is so fast that the whole process of preparing a set of CRs, after pre-cleaning of the FTO substrates, takes less than 30 min. Most importantly, the present method enables low temperature fabrication of Pt electrodes even on flexible substrates. (C) 2016 Elsevier B.V. All rights reserved.</P>
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