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Oyinleye O. E.,Adeniran S. A.,Ogunsuyi O. M.,Oyeyemi I. T.,Bakare A. A. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
Telfairia occidentalis (Hook F.) and Vernonia amygdalina are two commonly consumed vegetables, individually and as recipes, for their nutritive and medicinal values in Africa. Data on reproductive toxicity and DNA damage of the combination of these plants on the male reproductive system is scarce. We evaluated the toxic and genotoxic effects of aqueous extracts of T. occidentalis and V. amygdalina and their combination on the reproductive cells of male Swiss albino mice. Groups of mice exposed to five concentrations (62.5–1000 mg/kg) of each extract or combination as against distilled water and cyclophosphamide (20 mg/kg bwt) as negative and positive control respectively were examined for abnormal sperm morphology, organo-somatic index and pathological changes. Each of the extracts significantly reduced the frequency of aberrant sperm cells, while their combination provoked increasing sperm abnormalities when compared with the negative control. None of the extracts induced adverse effect on body and testes weight of exposed mice. There was no visible histological lesion induced by extracts of V. amygdalina but there were residual bodies indicative of increased spermatogenesis. The extracts of T. occidentalis induced necrosis only at 1000 mg/kg, while with the combination, there were necrotic cells, mild congestion of blood vessels, and the seminiferous tubules had irregular outlines. These indicates that aqueous extracts of T. occidentalis and V. amygdalina individually at the tested doses did not evoke significant induction of genetic damage in the sperm head, and pathological changes unlike the combination in mice.
Funmilayo I.D. Afolayan,Blessing Erinwusi,Oyetunde T. Oyeyemi 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.2
Background: Studies have shown that curcumin from Curcuma longa has a wide range of medicinal and immunomodulatory properties. These activities have, however, been hindered by its low bioavailability. Meanwhile, incorporation of nanoparticles has been shown to increase bioavailability of certain drugs. This study was, therefore, conducted to comparatively evaluate the immunomodulatory activity of free and nanoparticulate curcumin in mice. Methods: Healthy albino mice were sensitized with sheep red blood cells (SRBCs) and thereafter free and nanoparticulate curcumin were administered orally at doses of 5 mg/kg/day and 10 mg/kg/day for 10 days to the mice. The assessment of the immunomodulatory activity was carried out by determining the humoral and cell-mediated immune responses using hemagglutination and delayed-type hypersensitivity assays, respectively. Hematological components and some lymphoid organs of treated mice were further evaluated. Results: The study showed that nanoparticulate curcumin stimulated higher early cell-mediated immune response at 5 mg/kg and 10 mg/kg when compared to control. While nanoparticulate curcumin significantly stimulated primary humoral immune response with 9.00 ± 1.00 antibody titre (p < 0.05), the free curcumin suppressed the immunity with 3.33 ± 0.67 antibody titre when compared to control. Similar result was observed with secondary humoral antibody titres. Production of white blood cells and weight of the lymphoid organs were also enhanced in the groups that received 10 mg/kg nanocurcumin. Conclusion: This work showed that poly d,l-lactic-co-glycolic acid entrapped curcumin nanoparticle could increase bioavailability of curcumin for improved immunity.