GASOLINE-INDUCED NEPHROPATHY: SIMULTANEOUS DOSE-DEPENDENT ACCUMULATION OF RENAL HYALIN DROLETS AND a_2u -GLOBULIN IN MALE PATS

B.D.Garg,M.J.Olson,W.F.Demyan,A.K.Roy 한국자동차공학회 1987 한국자동차공학회 학술강연초록집 Vol.- No.-

A phase IIa dose-finding and safety study of first-line pertuzumab in combination with trastuzumab, capecitabine and cisplatin in patients with HER2-positive advanced gastric cancer

Kang, Y-K,Rha, S Y,Tassone, P,Barriuso, J,Yu, R,Szado, T,Garg, A,Bang, Y-J Nature Publishing Group 2014 The British journal of cancer Vol.111 No.4

<P><B>Background:</B></P><P>Pertuzumab plus trastuzumab provides a more comprehensive blockade of HER2 signalling than trastuzumab alone. Therefore, we conducted a phase IIa study of the pharmacokinetics and safety of pertuzumab plus trastuzumab and chemotherapy in advanced gastric cancer (aGC).</P><P><B>Methods:</B></P><P>Patients received pertuzumab 840 mg for cycle 1 and 420 mg q3w for cycles 2–6 (Arm A) or pertuzumab 840 mg q3w for six cycles (Arm B). Trastuzumab, cisplatin and capecitabine were also given for six cycles, then trastuzumab q3w until disease progression or unmanageable toxicity. The co-primary endpoints were day 43 pertuzumab serum trough concentration (<I>C</I><SUB>min</SUB>) and safety.</P><P><B>Results:</B></P><P>Thirty patients were randomised. Mean pertuzumab <I>C</I><SUB>min</SUB> at day 43 was 40.0 <I>μ</I>g ml<SUP>−1</SUP> (s.d.: 17.3) in Arm A and 62.7 <I>μ</I>g ml<SUP>−1</SUP> (29.1) in Arm B. Mean day 43 <I>C</I><SUB>min</SUB> in Arm A was ∼37% lower than that seen in metastatic breast cancer. The safety profiles were similar between arms and treatment was well tolerated. Partial responses were achieved by 86% and 55% of patients in Arms A and B, respectively.</P><P><B>Conclusions:</B></P><P>On the basis of the pharmacokinetic and safety data, the 840 mg q3w pertuzumab dose has been selected for a phase III study of pertuzumab, trastuzumab and chemotherapy in HER2-positive aGC.</P>

EFFECT OF FUEL CHOICE ON NANOPARTICLE EMISSION FACTORS IN LPG-GASOLINE BI-FUEL VEHICLES

A. MOMENIMOVAHED,J. S. OLFERT,M. D. CHECKEL,S. PATHAK,V. SOOD,L. ROBINDRO,S. K. SINGAL,A. K. JAIN,M. O. GARG 한국자동차공학회 2013 International journal of automotive technology Vol.14 No.1

Nanoparticle and gas-phase emission factors are presented for a liquefied petroleum gas (LPG) passenger vehicle and are compared to gasoline operation. A bi-fuel LPG-gasoline vehicle certified for use on either fuel was used as the test vehicle so that a direct comparison of the emissions could be made based on fuel choice. These values were considered along with previous studies to determine the relative change in particulate emissions due to fuel choice over a wide range of vehicles and operating conditions. The vehicle examined in this study was tested on a chassis dynamometer for both steadystate and transient conditions. Transient test cycles included the US FTP72 driving cycle, Japanese driving cycle and modified Indian driving cycle while steady-state tests were done at vehicle speeds ranging from 10-90 km/hr in various transmission gears. Exhaust particle size distributions were measured in real-time using a differential mobility spectrometer (DMS50), and particle number and particle mass emission factors were calculated. For both fuels, the majority of the particles ranged from 5 to 160 nm in terms of particle diameter, with typically more than 85% of the particles in the nucleation mode (between 5-50 nm). In most cases, the vehicle produced a greater fraction of larger (accumulation mode) particles when fuelled on LPG. Using the data in the literature as well as the data in the current study, gasoline fuel produces 4.6 times more particles in terms of number and 2.1 times more particles in terms of mass.

Shear correction factors of a new exponential functionally graded porous beams

Mohammed Sid Ahmed Houari,Aicha Bessaim,Tarek Merzouki,Ahmed Amine Daikh,Aman Garg,Abdelouahed Tounsi,Mohamed A. Eltaher,Mohamed-Ouejdi Belarbi 국제구조공학회 2024 Structural Engineering and Mechanics, An Int'l Jou Vol.89 No.1

This article introduces a novel analytical model for examining the impact of porosity on shear correction factors (SCFs) in functionally graded porous beams (FGPB). The study employs uneven and logarithmic-uneven modified porositydependent power-law functions, which are distributed throughout the thickness of the FGP beams. Additionally, a modified exponential-power law function is used to estimate the effective mechanical properties of functionally graded porous beams. The correction factor plays a crucial role in this analysis as it appears as a coefficient in the expression for the transverse shear stress resultant. It compensates for the assumption that the shear strain is uniform across the depth of the cross-section. By applying the energy equivalence principle, a general expression for static SCFs in FGPBs is derived. The resulting expression aligns with the findings obtained from Reissner’s analysis, particularly when transitioning from the two-dimensional case (plate) to the onedimensional case (beam). The article presents a convenient algebraic form of the solution and provides new case studies to demonstrate the practicality of the proposed formulation. Numerical results are also presented to illustrate the influence of porosity distribution on SCFs for different types of FGPBs. Furthermore, the article validates the numerical consistency of the mechanical property changes in FG beams without porosity and the SCF by comparing them with available results.

Role of debulking mucoid ACL in unicompartmental knee arthroplasty: a prospective multicentric study

( Amyn M. Rajani ),( Urvil A. Shah ),( Anmol R. S. Mittal ),( Sheetal Gupta ),( Rajesh Garg ),( Meenakshi Punamiya ) 대한슬관절학회 2022 대한슬관절학회지 Vol.34 No.-

Background: Mucoid degeneration of the anterior cruciate ligament (ACL) has been shown to cause restricted terminal range of motion and rest pain. If present in a patient undergoing unicompartmental knee arthroplasty, it can deteriorate the final outcome. This study aims to compare functional and clinical outcomes of debulking the mucoid ACL in patients undergoing mobile-bearing unicompartmental knee arthroplasty (UKA). Methods: Patients with mucoid ACL undergoing mobile-bearing UKA at five different centres by five different arthroplasty surgeons were included. They were segregated into two groups matched for all demographic and preoperative values: group A did not undergo debulking; group B underwent open debulking by a 15-number blade prior to UKA. Patient-related outcome measures, rest pain, clinical outcomes, and subjective patient satisfaction were recorded and compared at 2 years follow-up. Results: A total of 442 patients (226 patients underwent debulking, 216 patients did not undergo debulking) were included. Both groups showed overall improvement after surgery, however, patients who underwent debulking performed better at 2 years follow-up in terms of Knee Society functional score, International Knee Documentation Committee scores, range of motion, rest pain and overall patient satisfaction (p < 0.05) as compared with their counterparts. Conclusions: Debulking of mucoid ACL in patients undergoing unicompartmental knee arthroplasty significantly reduces the rest pain and improves the final range of motion of the knee joint, subsequently improving the overall functional and clinical outcome of the patient and resulting in greater patient satisfaction.

Multiscale bending and free vibration analyses of functionally graded graphene platelet/ fiber composite beams

A. Garg,T. Mukhopadhyay,H.D. Chalak,M.O. Belarbi,L. Li,R. Sahoo 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.44 No.5

In the present work, bending and free vibration analyses of multilayered functionally graded (FG) graphene platelet (GPL) and fiber-reinforced hybrid composite beams are carried out using the parabolic function based shear deformation theory. Parabolic variation of transverse shear stress across the thickness of beam and transverse shear stress-free conditions at top and bottom surfaces of the beam are considered, and the proposed formulation incorporates a transverse displacement field. The present theory works only with four unknowns and is computationally efficient. Hamilton’s principle has been employed for deriving the governing equations. Analytical solutions are obtained for both the bending and free vibration problems in the present work considering different variations of GPLs and fibers distribution, namely, FG-X, FG-U, FG-Λ, and FG-O for beams having simply-supported boundary condition. First, the matrix is assumed to be strengthened using GPLs, and then the fibers are embedded. Multiscale modeling for material properties of functionally graded graphene platelet/fiber hybrid composites (FGGPL/FHRC) is performed using Halpin-Tsai micromechanical model. The study reveals that the distributions of GPLs and fibers have significant impacts on the stresses, deflections, and natural frequencies of the beam. The number of layers and shape factors widely affect the behavior of FG-GPL-FHRC beams. The multilayered FG-GPL-FHRC beams turn out to be a good approximation to the FG beams without exhibiting the stress-channeling effects.

Free vibration analysis of power-law and sigmoidal sandwich FG plates using refined zigzag theory

Aman Garg,Simmi Gupta,Hanuman D. Chalak,Mohamed-Ouejdi Belarbi,Abdelouahed Tounsi,Li Li,A.M. Zenkour Techno-Press 2023 Advances in materials research Vol.12 No.1

Free vibration analysis of power law and sigmoidal sandwich plates made up of functionally graded materials (FGMs) has been carried out using finite element based higher-order zigzag theory. The present model satisfies all-important conditions such as transverse shear stress-free conditions at the plate's top and bottom surface along with continuity condition for transverse stresses at the interface. A Nine-noded C0 finite element having eleven degrees of freedom per node is used during the study. The present model is free from the requirement of any penalty function or post-processing technique and hence is computationally efficient. The present model's effectiveness is demonstrated by comparing the present results with available results in the literature. Several new results have been proposed in the present work, which will serve as a benchmark for future works. It has been observed that the material variation law, power-law exponent, skew angle, and boundary condition of the plate widely determines the free vibration behavior of sandwich functionally graded (FG) plate.

Wrapper Based Wavelet Feature Optimization for EEG Signals

Girisha Garg,A.P. Mittal,Vijander Singh,J.R.P Gupta 대한의용생체공학회 2012 Biomedical Engineering Letters (BMEL) Vol.2 No.1

Purpose In this paper a computationally efficient wrapper based Wavelet Feature Optimization (WFO) is developed. The algorithm is developed for the classification of high dimensional EEG signals which may suffer from the curse of dimensionality and sub optimal feature selection. Methods The key design phases of the algorithm involve: 1)Feature Transformation of the original EEG signals using Discrete Wavelet Transform; 2) Feature Extraction using the concept of Relative Wavelet Energy (RWE) 3) Selecting the optimal subset of the RWE features using wrapper approach. In contrast to the methods guided by the filter technique of feature selection, this approach uses the wrapper based method to select the optimal and a very low dimensional feature space from the wavelet features. Results The highlight of the algorithm is that in addition to increase the computational efficiency, it also enhances the predictive power of the system without any loss of relevant information. This paper includes the experimentation performed on EEG datasets using WFO algorithm. Conclusions The algorithm gives consistent and excellent performance for the EEG datasets. The feature sets obtained with the help of WFO are also tested using mutual information methods to confirm the optimality of the wavelet feature subset.

Patient-reported quality of life recovery curves after robotic prostatectomy are similar across body mass index categories

Tullika Garg,Amanda J. Young,Korey A. Kost,Alyssa M. Park,John F. Danella,H. Lester Kirchner 대한비뇨의학회 2017 Investigative and Clinical Urology Vol.58 No.5

Purpose: To assess the impact of body mass index (BMI) on postoperative recovery curve of urinary and sexual function after robotic-assisted laparoscopic prostatectomy (RALP). We hypothesized that overweight and obese men have different recovery curves than normal weight men. Materials and Methods: We reviewed preoperative and postoperative surveys from 691 men who underwent RALP from 2004–2014 in an integrated healthcare delivery system. Survey instruments included: sexual health inventory for men (SHIM), urinary behavior, leakage, and incontinence impact questionnaire (IIQ). A repeated measures analysis with autoregressive covariance structure was employed with linear splines with 2 knots for the time factor. We fit unadjusted and adjusted models and stratified by BMI (under/normal weight, overweight, and obese). Adjusted models included age, race/ethnicity, smoking status, diabetes, operation length, prostate-specific antigen, pathologic stage, nerve-sparing status, and surgery year. Results: Mean age was 59 years. Most men were overweight (43%) and obese (42%). There were no significant differences in mean baseline SHIM, urinary behavior, leakage, and IIQ scores by BMI category. All groups had initial steep declines in urinary and sexual function in the first 3 months after RALP. There were no significant differences in postoperative urinary and sexual function score curves by BMI category. Conclusions: The pattern of urinary and sexual function recovery was similar across all BMI categories. Overweight and obese men may be counseled that urinary and sexual function recovery curves after surgery is similar to that of normal weight men.

Effects of glenohumeral corticosteroid injection on stiffness following arthroscopic rotator cuff repair: a prospective, multicentric, case-control study with 18-month follow-up

Amyn M. Rajani,Urvil A Shah,Anmol RS Mittal,Sheetal Gupta,Rajesh Garg,Alisha A. Rajani,Gautam Shetty,Meenakshi Punamiya,Richa Singhal 대한견주관절학회 2023 대한견주관절의학회지 Vol.26 No.1

Background: This study aimed to analyze the efficacy of single-dose corticosteroid injection (CSI) administered at 6 weeks postoperative to treat stiffness following arthroscopic rotator cuff repair (ARCR). Methods: In this prospective, multicentric, case-control study, post-ARCR stiffness at 6 weeks was treated with either a single dose of intra-articular CSI (CSI group) or physical therapy with oral analgesics (non-CSI group). Pain intensity according to visual analog scale (VAS), functional outcome using the Constant Murley Shoulder Score, time to return to activities of daily living (ADLs), and retear rate were recorded at 6 weeks, 9 weeks, 12 weeks, 6 months, 12 months, and 18 months postoperatively in both groups. Results: A total of 149 patients (54.5%) in the CSI group and 124 patients (45.5%) in the non-CSI group were included in this study. Pain and function were significantly better in the CSI group at 9-week, 12-week, and 6-month (P<0.001) follow-up, whereas they were not significantly different when the groups were compared at 12- and 18-month follow-up. The mean duration to return to ADLs was significantly shorter (P<0.001) in the CSI group. The incidence of retears was not significantly different (P=0.36) between groups at the end of 18 months of follow-up. Conclusions: Single-dose intra-articular CSI administered at 6 weeks postoperative to treat post-ARCR stiffness significantly improved pain, function, and duration of return to ADLs without increasing the risk of retears compared to patients who did not receive intra-articular CSI.