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적색식용색소인 아마란스의 약동학 특성 및 위장관 투과도 연구
한유진(Youjin Han),구수현(Soo Hyeon Goo),남소정(So Jeong Nam),강윤주(Yun Ju Kang),권미화(Mihwa Kwon),송임숙(Im-Sook Song) 한국생명과학회 2017 생명과학회지 Vol.27 No.7
적색 아조류 타르색소인 아마란스는 인공식용색소로 식품, 화장품, 의약품에 광범위하게 사용되고 있음에도 불구하고, 경구로 복용하였을 때 위장관 흡수율이나 흡수특성에 대해 연구된 바가 없다. 본 연구의 목적은 아마란스의 정맥투여 또는 경구 투여 후 약동학 특성을 평가하고 diffusion chamber system을 이용하여 위장관 흡수율 및 투과도를 평가하고자 하였다. 정맥투여된 아마란스는 38.8분의 소실반감기로 빠르게 혈중에서 소실된다. 그러나 경구투여된 아마란스는 생체이용률도 55.6%로 높은 위장관 흡수율을 나타내며 408분까지 혈중농도가 증가하고 24시간까지 혈중에 남아있는 특성을 나타내었다. 이는 아마란스의 위장관 흡수가 오랫동안 지속적으로 일어나는 것을 의미한다. 이를 확인하기 위하여 소장의 흡수부위를 공장, 회장사부, 회장하부로 나누어 위장관 투과도를 평가하고 투과성이 잘 알려진 지표물질과 비교하였다. 연구결과 아마란스의 위장관투과성은 투과도가 매우 높은 caffeine의 1/3정도의 투과도를 보이고, 중등도의 투과도를 보이는 atenolol과 유사한 투과도를 나타내었으며 회장상부에서의 투과도가 가장 높았다. 결과를 종합하면, 아마란스는 경구투여된 뒤 지속적으로 흡수되며 흡수율도 50% 이상을 보이므로, 식품, 립케어 화장용품, 경구용 의약품에 아마란스 등의 색소가 포함될 경우에는 첨가량 등을 고려하여 신중하게 사용해야 할 것이다. Although amaranth, a red-colored tar dye, is usually used in foods, cosmetics, and pharmaceutics, its bioavailability and intestinal absorption have not previously been investigated. Therefore, the purpose of this study was to investigate the pharmacokinetics properties and intestinal permeability of amaranth in rats following the intravenous and oral administration of this dye. Amaranth rapidly disappeared from the plasma following the intravenous injection, with a half-life of 38.8 minutes. However, the plasma concentration of amaranth was increased to 400 minutes following the oral administration of amaranth, and the absorption time and bioavailability of amaranth were calculated to be 356 minutes and 55.6%, respectively. This suggests that once amaranth exists in the gut, this dye may be efficiently and effectively absorbed. Consistent with this result, the intestinal permeability of amaranth was comparable to atenolol, a marker compound of moderate permeability, and to one-third of caffeine’s intestinal permeability (a highly permeable compound). In conclusion, a significantly long absorption time and substantial intestinal absorption of amaranth was observed following the oral administration of amaranth at a dose of 300 mg/kg in rats, despite the rapid elimination of this dye from the plasma. These results may suggest the necessity of a careful and limited use of amaranth dye when it is added to food, lip-care cosmetics, and orally administered pharmaceutics.
아동상담자의 자기돌봄이 심리적 소진에 미치는 영향에서 마음챙김과 직무열의의 순차적 이중매개효과
김보은(Boeun Kim),한유진(Youjin Han) 한국생애놀이치료학회 2023 한국생애놀이치료학회지 Vol.6 No.1
This study examined the relationship between self-care and burnout of child counselors, focusing on the sequential mediational role of mindfulness and work engagement. A survey was conducted on 229 child counselors in Seoul and the metropolitan area. In addition, Data analysis was performed using SPSS 25.0 and Process macro ver. 4.1(Model 6). The main results of this study are as follows. First of all, child counselor’ self-care was found to have a significant direct effect on burnout. After that, both child counselor’ mindfulness and work engagement had significant single mediator effect on the relationship between their self-care and burnout. Finally, the indirect path linking child counselor’ self-care and burnout through their mindfulness and work engagement was significant, and the sequential mediational model was supported. Through these results, practical measures to deal with the burnout of child counselors can be considered.
원형탈모증을 앓고 있는 만 4세 유아의 아동중심놀이치료 사례연구
장정순(Jeong Soon Chang),한유진(Youjin Han) 한국생애놀이치료학회 2023 한국생애놀이치료학회지 Vol.6 No.1
This study is a case study of child-centered play therapy for a four-year-old child suffering from circular alopecia. It aims to analyze the play theme, and verify changes in psychological evaluation. The child received one year of hospital treatment for circular alopecia, which was relieved but recurred. In order to resolve the child’s psychosocial difficulties due to the recurrence, this case was referred to play therapy. In this study has found first, the themes of play manifested in the early stages were relationship, dependence, parenting, and mastery. In the 1st middle stage, the themes were relationship, dependence, mastery, parenting and anxiety appeared. Also in the 2nd middle stage, the themes of relationship, power and control, dependence, revenge, safety and security, mastery, parenting, protection were found. In the later stage, the themes of relationship, safety and security, mastery, parenting, integration, self-sufficiency, and resilience appeared. Second, child-centered play therapy was confirmed to provide positive changes as a result of psychological evaluations conducted before and after. The significance of this study is that after child-centered play therapy was performed on a four-year-old child suffering from circular alopecia, the play themes were analyzed and changes in psychological evaluation were confirmed.