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췌담도 ; 간세포암에 의해 발생된 간외담관종괴의 관강내 세경초음파검사(IDUS)의 소견
문종호 ( Mun Jong Ho ),주종우 ( Ju Jong U ),권계원 ( Kwon Gye Won ),진소영 ( Jin So Yeong ),차상우 ( Cha Sang U ),천영국 ( Cheon Yeong Gug ),김영석 ( Kim Yeong Seog ),조영덕 ( Jo Yeong Deog ),김연수 ( Kim Yeon Su ),이준성 ( Lee Ju 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<목적> 간세포암으로 인한 간외담관폐쇄는 간세포암의 1∼5% 정도에서 관찰되는 비교적 드문 병변이다. 이러한 병변은 수술적 절제가 가능한 경우가 많아(?) 수술전 진단이 중요하나 지금까지의 영상진단 방법으로는 간외담관암과의 감별이 어려웠다. 이에 연자 등은 간외담관협착으로 유도선하 관강내 세경초음파검사(intraductal US, 이하 IDUS)를 시행한 환자 중 간세포암으로 인한 간외담관폐쇄 소견을 보인 환자들을 후향적으로 조사하여 IDUS상 특징적인
대한간학회지 제8차 춘계학술대회 초록집 : 서울아산병원 간이식 500예 보고
이승규 ( Lee Seung Gyu ),황신 ( Hwang Sin ),박광민 ( Park Gwang Min ),김기훈 ( Kim Gi Hun ),이영주 ( Lee Yeong Ju ),안철수 ( An Cheol Su ),문덕복 ( Mun Deog Bog ),주종우 ( Ju Jong U ),정영화 ( Jeong Yeong Hwa ),이영상 ( Lee Yeong 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
대한간학회지 제7차 추계학술대회 논문집 : 전격성 간부전에 대한 응급 간이식수술: 생체간이식을 중심으로
이승규 ( Lee Seung Gyu ),박광민 ( Park Gwang Min ),황신 ( Hwang Sin ),김기훈 ( Kim Gi Hun ),전장용 ( Jeon Jang Yong ),주선형 ( Ju Seon Hyeong ),주종우 ( Ju Jong U ),문덕복 ( Mun Deog Bog ),이영주 ( Lee Yeong Ju ),민병철 ( Min Bye 대한간학회 2001 Clinical and Molecular Hepatology(대한간학회지) Vol.7 No.3(S)
간 세포암에서 VEGF, TGF-β1, b-FGF 발현의 의의
김성용,남충현,주종우,채만규,백무준,이문수,김형철,안현철,김홍수,김창진,김창호 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1
Purpose: Angiogenesis is important for the proliferation and the metastasis of solid tumors. The growth of a solid tumor is widely recognized to depend on the process of neovascularrozation. Without angiogenesis, tumors cease to grow beyond even a few milimeters in diameter. It has been shown that tumor vascular density is an independent prognostic marker in several types of human tumors and is known to correlate with poor prognosis. To date, many angiogenic factors have been identified, such as transforming growth factor-α(TGF-α), transforming growth factor-β(TGF-β), fibroblast growth factor family(FGF), vascular endothelial growth factor(VEGF), platelet derived endothelial cell growth factor(PD-ECGF), tumor necrosis factor-α(TNF-α), and angiogenin. Hepatocellular carcinoma(HCC) is the second most common tumor in Korean males and is known as a typical hypervascular tumor with frequent portal vein invastion. The authors identified the expreesion of VEGF, TGF-β1, and b-FGF in HCC specimens and evaluated the relationship between these growth factors and the clinicopathologic characteristics of HCC. Method: We reviewed the medical records of 30 patients who were diagnosed as hepatocellular carinoma treated with hepatic resection between January 1994 and December 1998 in Soonchunhyang University Chunan Hospital. The selection of the cases was decided according to the condition of paraffin block fixation. The prognostic factors such as age, sex, tumor size, concentration of serum α-fetoprotein, presence of liver cirrhosis, presence of tumor emboli in portal vein, TMN stage, amount of transfusion during the operation, hepatitis B virus(HBV) infection, and Edmonson-Steiner(E-S) grade were investigated. Relationship between the prognostic factors and the immunopathologic expression of the TGF-β1, b-FGF, and VEGF was examined. Result: Thirty patients (24 males, 6 females) were included in the current study. The patient's mean age was 50.6 years and the age ranged from 36 to 65 years. The mean size of the tumor was found to be 5.2cm. All the patients were follewed up for 7 to 63 months. Child's classification A patients were 23(76.7%)cases, B patients were 7(23.3%)cases, and C was none. Immunohistochemical staining of HCC tumor mass in VEGF expression patients were 17(56.7%), b-FGF expression patients were 10(33.3%), and TGF-β1 expression patients were 10(33.3%). VEGF expression or more than one positive expression among the three factors correlated with tumor size and the stage of HCC but did not correlated with other clinicopathological characteristics. TGF-β1 and b-FGF did not correlate with any clinicopathological characteristics. Conclusion: The results suggest that the expression of VEGF or more than one positive expression among the three factors in HCC cells may be a significant prognostic factor of HCC.