기니픽을 이용한 Sweet Bee Venom의 항원성 평가

조병준,권기록,Cho, Byung-Jun,Kwon, Ki-Rok 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.4

Objectives: This study was performed to examine the antigenic potential of pure melittin (Sweet Bee Venom - SBV) extracted from the bee venom by utilizing protein isolation method of gel filtration. Methods: All experiments were conducted at Biotoxtech (Chungwon, Korea), authorized a non-clinical studies institution, under the regulations of Good Laboratory Practice (GLP). Antigenic potential of SBV was examined by active systemic anaphylaxis (ASA) and passive cutaneous anaphylaxis (PCA) in guinea pigs. SBV was subcutaneously administered at 0.07 and 0.28mg/kg and also as a suspension with adjuvant (Freund's complete adjuvant: FCA). Ovalbumin (OVA) as a suspension with adjuvant was used to induce positive control response ($5mg/m{\ell}$-FCA). Results: 1. In the ASA test, experimental groups showed some symptoms of anaphylaxis like piloerection, hyperpnea and staggering gait. 2. In the PCA test, low dosage group did not show any antibody responses, whereas high dosage group showed positive responses. 3. In the weight measurement and clinical observation, experimental groups didn't show any significant changes compared with control group. 4. In the autopsy of body, the abnormalities of lung were detected in the corpse. This means that the cause of death may induced anaphylactic shock. Conclusions: Above findings suggested that SBV had antigenic potential in guinea pig. Further studies on the subject should be conducted to yield more concrete evidences.

Colon26-L5 대장암 세포를 이용한 간전이 모델에 산삼약침 처치가 혈중 cytokine에 미치는 영향

조병준,권기록,Cho, Byung-Jun,Kwon, Ki-Rok 대한약침학회 2006 Journal of pharmacopuncture Vol.9 No.1

Objective : This experiment was conducted to evaluate inhibitory effects against hepatic metastasis by cultivated wild ginseng Herbal Acupuncture. Methods : Colon26-L5 carcinoma cells were injected through hepatic portal vein to induce hepatic metastatic cancer. After treated cultivated wild ginseng Herbal Acupuncture and investigated various kinds of cytokine level using cytokine chip. Results : 1. Mice treated with cultivated wild ginseng Herbal Acupuncture reduced the level of $IL-l{\alpha}$, $IL-{\beta}$, and $TNF-{\alpha}$ compared to the control group. 2. Mice treated with cultivated wild ginseng Herbal Acupuncture was not showed significant change in the level of IL-4, IL-l0, IL-12 and $INF-{\gamma}$ compared to the control group. 3. Observing the level of various kinds of cytokine, cultivated wild ginseng Herbal Acupuncture was suppressed pro-inflammatory cytokine. These findings indicate cultivated wild ginseng Herbal Acupuncture is possible to use the inflammatory disease and futher studies carry out for the explanation of anticancer mechanism.

산삼약침의 자가치료능에 대한 제언

조병준,권기록,Cho, Byung-Jun,Kwon, Ki-Rok 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.2

Objectives & Methods: This research may accounts for Self Targeting Therapy (STT) which is a peculiar operation of Mountain Ginseng Pharmacopuncture. The objectives include analysis of its mechanism and reporting of clinical cases. Results: 1. STT of Mountain Ginseng Pharmacopuncture refers to the function of curing and making a diagnosis of the disease by oneself. 2. The mechanism of STT is to pursue the latent illness and make the remedial action by oneself. In this process, the symptom of latent disease is outwardly expressed. 3. The most popular symptom expressed is manifestation of pecular sensation along the specific meridians. Then followed headache, dizziness, powerless and etc. Diverse symptoms can be expressed by a patient. 4. If the revealed symptoms are carefully observed, the cause of the disease or the patient state can be diagnosed easily. Conclusion: The mechanism of STT of Mountain Ginseng Pharmacopuncture can be a great asset in clinical trials. Other studies on STT of Mountain Ginseng Pharmacopuncture should be followed in the future.

질병 발생의 원인과 특성에 대한 제언

조병준,권기록,Cho, Byung-Jun,Kwon, Ki-Rok 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.2

Objectives & Methods: This suggestion was attempted to be elevated the recognition of common characteristics in disease. So, we performed to analyze the correlation of common cause of disease, characteristics of human body, and medical treatment. And the results are as follows. Results: 1. The cause of disease is consist of genetic factor, aging, habit, food of not good in health, weather, environment, deficit of the physical activity, stress and so on. 2. Generally, human has common and individual weakness. Individual weakness is appeared similar to the occurrence of volcano and lapse. 3. The correlation of disease and medical treatments is possible to explain using the quotation of the law of motion made by Isaac Newton, the great physicist. 4. When the process of the medical treatment was not progressed, the prognosis is determined by the correlation of the homeostasis(H') in human body and the homeostasis(H) of disease. 5. The prognosis of disease is determined by the relationship between the energy of disease(F) and medical treatment(F'). 6. The exact diagnosis is possible to predict the treatment sequence, and the facts that homeostasis in human body and disease, relationship between the energy of disease(F) and medical treatment(F'), action and reaction are important to determine the prognosis. 7. The careful observation of improving response and worsening action of disease becomes available for exact prognosis. Conclusion: The above described contents may be useful in clinical studies, and the concrete clinical reports about this will be made afterward.

FCAW 이종접합에서 용접자세에 따른 기계적 시험 특성 평가

조병준(Byung-Jun Cho),이성준(Soung-Jun Lee) 한국산학기술학회 2019 한국산학기술학회논문지 Vol.20 No.8

조선소, 교량 구조물, 건설기계, 플랜트 산업 등 다양한 분야에서 폭 넓게 활용되고 있는 이산화탄소 아크용접(FCAW: Flux Cored Arc Welding)은 피복 아크 용접(SMAW: Shielded Metal Arc Welding)의 단점을 보완하기 위한 대안으로 1950년대 초 개발되었다. FCAW는 모든 자세에서 용접이 가능하고 작업여건 변수가 많은 현장에서 우수한 품질을 얻을 수 있는 장점이 있어 탄소강과 합금강의 중판, 후판 용접에 많이 사용되고 있다. 본 연구에서는 FCAW를 이용하여 SS400(일반구조용 압연강재)와 SM490A(용접구조용 압연강재)를 이종용접한 후 용접부의 기계적 특성(인장시험, 굽힘시험, 경도시험, 충격시험, 매크로시험)을 분석하고 다음과 같은 결론을 도출하였다. 인장시험 결과, 모든 용접자세에서 KS 규격 인장강도 범위(400∼510 N/㎟)를 만족하였다. 굽힘시험 결과, 대부분의 시편에서 굽힘시 표면의 터짐 현상이나 기타 결점이 나타나지 않았고, 소성변형 후에도 충분한 인성을 발휘하는 것을 확인할 수 있었다. 경도시험결과, 모든 결과 값이 KS B 0893의 규격치 350Hv보다 낮게 나타나 양호한 것으로 판단된다. 충격시험 결과, 모든 결과가 KS 기준 수치인 27J 보다 큰 것으로 나타났다. 매크로시험 결과 용접부의 형상별로 균일한 조직 상태를 나타냈으며, 용접부 전단면에 걸쳐 내부 결함, 기포 또는 불순물 등이 발견되지 않아 라미네이션의 우려가 없는 것으로 나타났다. Flux cored arc welding (FCAW), which is used widely in many fields, such as shipyards, bridge structures, construction machinery, and plant industry, is an alternative to shielded metal arc welding (SMAW). FCAW is used largely in the welding of carbon and alloy steel because it can be welded in all poses and obtain excellent quality in the field under a range of working conditions. In this study, the mechanical properties of welded parts were analyzed after different welding of SS400 and SM490A using FCAW. The following conclusions were drawn. The tensile test results satisfied the KS standard tensile strength in the range of 400~510 N/mm2 in all welding positions. The bending test confirmed that most of the specimens did not show surface breakage or other defects during bending and exhibited sufficient toughness, even after plastic deformation. The hardness test results were lower than the standard value of 350 Hv of KS B 0893. Similar to the hardness test, were greater than the KS reference value. The macro test revealed no internal flaws, non-metallic inclusions, bubbles or impurities on the entire cross section of the weld, and there were no concerns regarding lamination.

한국형 119 구급헬멧의 컨센트 디자인 개선에 관한 연구

조병준(Byung-Jun Cho),신동민(Dong-min Shin) 한국컴퓨터정보학회 2018 韓國컴퓨터情報學會論文誌 Vol.23 No.2

In this paper, we propose an optimized size for paramedic helmets as personal safety equipment for emergency medical technician. This identified priorities for advanced loT technologies that need to be attached to paramedic Helmets. Paramedic helmets with advanced technology have been developed others, but they have not been developed for Korea. The products of kinds do not exist in Korea. Based on the average size of Korean men’s heads, this derived an optimized size for paramedic helmets. The optical width of this product would be 205 mm. The length would be 265 mm. The height would be 155 mm. The verified that this size meets the requirements of the authorizing certification institution. What paramedic most need in helmets is various kinds of functionality. The communication and information transmission features. In this study, many personal safety equipment for paramedics, including the extraction of an optimal size of strong emergency head-protection helmets to protect the head of the human body on helmets based on an design. We anticipate this result to be a basis for developing an even more sophisticated and functional paramedic helmet than those that currently exist

키넥트센서 데이터를 이용한 동작 인식 및 분류

조병준(Byung-jun Cho),장하영(Ha-Young Jang),장병탁(Byoung-Tak Zhang) 한국정보과학회 2012 한국정보과학회 학술발표논문집 Vol.39 No.2B

어려운 기도기 시뮬레이션에서 Macintosh, GlideScope®, AWS®, McGrath® 비디오 후두경의 비교분석

조병준(Byung-Jun Cho),문태영(Tae-Young Moon),김지희(Ji-Hee Kim),고장식(Jang-Sik Ko),문수재(Soo-Jae Moon) 한국산학기술학회 2015 한국산학기술학회 학술대회 Vol.2015 No.1

본 연구는 병원 전 단계 기도유지기의 성공 비율, 삽관 시간 및 도구 선호도에 관한 연구를 분석하기 위하여 강원도 지역에 소재한 K대학교 응급구조학과에 재학 중 22명을 대상으로 실시하였다. 수집된 자료는 SPSS 13.0 프로그램을 이용하여 빈도와 백분율, 병원 전 단계 시뮬레이션 교육에 대한 영향을 알아보기 위해 One-way ANOVA test 및 카이제곱 검정을 실시하였다. 결과는 다음과 같다. 연구는 Macintosh, GlideScope®, AWS®, McGrath® 비디오 후두경의 기관내 삽관 성공률과 삽관 시간, 시행자의 선호도를 비교하고 각 기구에 대한 응급구조학과 학생의 선호도를 비교 분석하고자 하였다. Macintosh, GlideScope®, AWS®, McGrath® 비디오 후두경의 기관내 삽관 성공률과 삽관 시간, 시행자의 선호도를 비교한 결과 의미 있는 차이를 보였다. 마네킨을 이용한 병원전 기도기인 1차 시도에서는 유의한 차이를 보였지만 2차에서 숙련이 된 경우이라서 큰 차이를 보이지 않았다. 기관내 삽관 기구의 선호도 조사에서는 AWS®를 가장 선호하였다. Purpose : It is proposed to compare the usefulness of Macintosh laryngoscope, GlideScope®, the AWS®, McGrath® and recorded performance skill and preference on Simman manikin. Methods : 22 EMT students were enrolled and performed. We tested the success rate, preference among the 4 devices, and the total procedure time of airway device insertion in different rooms. Results : There was statistically significant difference among the groups with Macintosh laryngoscope, GlideScope®, the AWS®, McGrath® respectively at the success rates, success times and the preference survey after the performance test. Conclusion: Airway devices of Macintosh laryngoscope, GlideScope®, the AWS®, McGrath® showed differences in success rate or time. The AWS® was the most preferred.

일반인의 벌자상에 대한 병원 전 약물투여의 영향요인분석

조병준(Byung-Jun Cho),문태영(Tae-Young Moon),김지희(Jee-Hee Kim),문수재(Soo-Jae Moon),이효철(Hyo-Cheol Lee),김진우(Jin-Woo Kim) 한국산학기술학회 2014 한국산학기술학회 학술대회 Vol.- No.-

본 연구는 벌자상에 대한 병원 전 응급처치와 약물투여가 환자의 예후에 미치는 영향정도를 파악하여 119 구급대의 병원 전 약물투여(에피네프린)를 고려해 보고자 시도하였다. 본 연구는 국내 언론 매체의 벌자상 기사를 중심으로 관련 자료를 조사 고찰한 연구로서 2013년 7월부터 10월까지 벌 자상으로 119 구급대를 이용한 환자를 대상으로 하였다. 벌자상으로 이송된 22명을 대상으로 119 구급 대원에 의해 작성된 구급일지와 아나필낙시스 환자 응급처치 세부 상황표, 환자의 연령과 성별, 약물투 여 여부, 환자 이송시간, 활력징후, 주요 증상, 응급처치내용 등을 조사하였다. 연구결과 환자의 중증도 가 심해질수록 산소공급, 정맥로 확보 후 수액투여, ECG 모니터링, 항히스타민제 투여가 높게 나타났 다. 케이스별로 보면 의료지도하에 병원 전 에피네프린을 투여한 경우 환자가 중증이었음에도 불구하 고 생존하였다. 결론적으로 벌자상 아나필낙시스 환자에 대한 119 구급대의 약물투여와 응급처치는 생 존에 중요한 영향을 나타내었다. 산소공급, 기도유지, 정맥로 확보와 함께 약물투여가 환자의 생존에 큰 영향을 미치므로, 119 구급대가 에피네프린을 사용할 수 있는 법적장치를 마련하여 아나필낙시스 환자의 생존율을 개선해야겠다.

약물투여가 벌자상환자에게 미치는 효과

조병준(Byung-Jun Cho),문수재(Soo-Jae Moon),김선예(Seon-Rye Kim) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.1

본 연구는 벌자상에 대한 병원 전 응급처치와 약물투여가 환자의 예후에 미치는 영향정도를 파악하여 119구급대의 병원 전 에피네프린 약물투여를 도입해 보고자 시도하였다. 본 연구는 소방본부 구급활동일지 정보를 통하여 벌자상 환자를 선별하여 후향적으로 조사하였다. 2013년 벌자상으로 119 구급대를 이용한 환자를 대상으로 하였다. 벌자상으로 이송된 22명을 대상으로 119 구급대원에 의해 작성된 구급활동일지와 아나필락시스 환자 응급처치 세부 상황표, 환자의 연령과 성별, 약물투여 여부, 환자 이송시간, 활력징후, 주요 증상, 응급처치내용 등을 조사하였다. 연구결과 환자의 중증도가 심해질수록 산소공급, 정맥로 확보 후수액투여, ECG 모니터링, 항히스타민제 투여가 나타났다. 케이스별로 보면 의료지도 하에 병원 전 에피네프린을 투여한 경우 환자가 중증이었음에도 불구하고 생존하였다. 결론적으로 벌자상 아나필락시스 환자에 대한 119 구급대의 약물투여와 응급처치는 생존에 중요한 영향을 나타내었다. 산소공급, 기도유지, 정맥로 확보와 함께 약물투여가 환자의 생존에 큰 영향을 미치므로, 119 구급대가 에피네프린을 사용할 수 있는 법적장치를 마련하여 아나필락시스 환자의 생존율을 개선해야할 것이다. The purpose of this study is effect factors of Pre-Hospital Medication in the Patients with Bee-Sting. This study is to identify the necessity of using epinephrine in prehospital stage from the perspective of early management of anaphylaxis following a bee sting. Methods: Patients suffering from a bee sting who used the 119 rescue between 2013 from 119 center data were included. Age, sex, month of injury, time factors, vital signs, medication, signs, distance factors, presence of cardiac arrest, AVPU triage by EMT were extracted. The severity of bee sting injury was divided into mild, moderate, and severe according to the presenting symptoms and signs. Results: The severe patients treated by using oxygen, IV, ECG, Medication. Anaphylaxis is a serious allergic reaction of rapid onset that may lead to death. One of Anaphylaxis patients lived by using epinephrine. Most patients collapsed at the scene of mount. Bee sting injuries occurred primarily during summer to the farmer. Nine patients collapsed at the scene. Bee sting injuries occurred primarily from June to October. Conclusion: The primary treatment for anaphylaxis is epinephrine. Epinephrine in pre-hospital stage is factors of essential for patients. Also epinephrine will permit to be equipped in the EMT-P and use of epinephrine by law.