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한국에서 지역에 따른 Helicobacter pylori 균주 내성
김재연 ( Jae Yeon Kim ),김나영 ( Na Young Kim ),김성중 ( Sung Jung Kim ),백광호 ( Gwang Ho Baik ),김광하 ( Gwang Ha Kim ),김정목 ( Jung Mogg Kim ),남령희 ( Ryoung Hee Nam ),김홍빈 ( Hong Bin Kim ),이동호 ( Dong Ho Lee ),정현채 ( H 대한소화기학회 2011 대한소화기학회지 Vol.57 No.4
Background/Aims: This study was performed to compare the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates among different regions of Korea. Methods: H. pylori were isolated from gastric mucosal biopsy specimens of 99 Koreans who lived in Gyeonggi (n=40), Kangwon province (n=40) and Busan (n=19) from April to August in 2008. All the patients had no history of H. pylori eradication therapy. The susceptibilities of the H. pylori isolates to amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin, and moxifloxacin were tested according to the agar dilution method. Results: There was a difference in resistance to clarithromycin in three institutes located among Gyeonggi (32.5%), Kangwon province (12.5%) and Busan (42.1%) by One way ANOVA test (p=0.027) and nonparametric Kruskal Wallis test (p=0.027). However, by post-hoc analysis, there was no statistically significant difference among three regions. Similarly, the other 7 antibiotics (amoxicillin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin) did not show any significant difference. Conclusions: There was no significant regional difference of the primary antibiotic resistance of H. pylori. However, the included patient number might not be enough for this conclusion demanding further evaluations. (Korean J Gastroenterol 2011;57:221-229)
체류성 장 증후군에서의 미소융모막효소 활성 및 점액 조성의 변화
백현욱(H . W . Baik),송영욱(Y . W . Song),최상운(S . W . Choi),정현채(H . C . Chung),이효석(H . S . Lee),윤용범(Y . B . Yun),송인성(I . S . Song),김정룡(C . Y . Kim) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A The effect of intestinal bacterial overgrowth on brush border hydrolases and composition of mucus was studied in rats with surgically introduced jejunal self-filling blind 1oops (SFBL), Enzymes and mucus were analyzed from blind loop segments, segments above and below the blind loops in the rats with SFBL, and three corresponding segments in the nonoperated controls. Sucrase and lactase activities were significantly reduced in homogenates from the self-filling blind loop, but alkaline phosphatase was not affected. Lactase activities were significantly reduced in homogenates from the three segments (proximal, blind loop, distal) of small intestine of rats with SFBL. The carbohydrate content of purified mucin was reduced in rats with SFBL than that of normal controls. N-acetyl neuraminic acid was significantly reduced in purified mucin from the SFBL. The results indicate that bacteria enhance the destruction of intestinal surface glycoproteins including disaccharidases. Since alkaline phosphatase, a glycoprotein, is not affected, the destruction is selective and presumably involves only the most exposed membrane components. And among disaccharidases, lactase activities were depressed in segments without direct contact with bacteria, suggesting that bacterial byproducts may exert effect on lactase synthesis systematically.
진행성 전신경화증 환자에서 식도관련증상과 식도 운동성과의 상호관계
송인성(I S Song),최규완(K W Choi),김정룡(C Y Kim),정영화(Y H Chung),이풍렬(P L Rhee),정현채(H C Jung),송영욱(Y W Song),이효석(H S Lee),윤용범(Y B Yoon) 대한소화기학회 1988 대한소화기학회지 Vol.20 No.3
N/A To investigate the correlation of esophageal symptoms w ith esophageal manometric parameters in patients with progressive systemic sclerosis (PSS) we tested esophageal motility in 10 patients with PSS who were admitted to Seoul National University Hospital from Feb. 1988 to Aug. 1988 and in 5 normal subjects, and we analyzed every parameters. The results were as follows: 1) 4 patients with esophageal symptoms showed marked decrease of lower esophageal sphincter pressure (LESP) (9.I+4.4 mmHg vs 27.9+8.5 mmHg; p< 0.005) while 6 patients having no esophageal symptoms showed normal LESP (29.4+4.0 mmHg vs 27.9+8.5 mmHg). 2) Normally propagating peristaltic waves were not found in the lower esophageal bodies of 4 patients who had esophagea] symptoms. On the other hand, among 6 patients without symptoms, 3 patients showed no propagating peristaltic waves while the other 3 patients showed normally propagating peristaltic waves in the lower esophagus. 3) The amplitudes of contraction waves at upper esophageal body of patients with esophageal symptoms were decreased compared with those of patients who had no esophageal symptom. (29.0+6.1 mmHg vs 21.0+4.4 mmHg; p<0.05) 4) In cases not showing normally propagating peristaltic waves, nonpropagating, hroad-based, low-amplitude contractions were found at the lower esophageal body. In conclusion, LESP is the esophageal manornetric parameter vhich seemed to be the most closely correlated with esophagea) symptoms in patients with PSS. And PSS seems to influence the upper esophageal contraction. Our data also indicates that esophageal manometry may be useful in the early detection of esophageal involvement in patients with PSS.