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이광재(Kwang Jae Lee),한광협(Kwang Heup Han),전재윤(Jae Yun Chun),문영명(Young Myoung Moon),이상인(Sang In Lee),박인서(In Suh Park),김호근(Ho Guen Kim),박찬일(Chan Il Park),오희철(Hee Chul Oh) 대한소화기학회 1997 대한소화기학회지 Vol.29 No.3
N/A Background/Aims: Chronic hepatitis type B is highly-prevalent in Korea. However, few studies about its natural history and prognostic factors have been presented until now. The natural course and long-term prognosis of chronic hepatitis type B varies greatly, and this diversity makes it difficu]t to predict the clinical course of individual patients. The histologic finding is known to be a important prognostic factor. Thus we conducted this study to evaluate the natural history and prognostic factors of chronic hepatitis type B in Korea. Methods: The authors analyzed the clinical courses of 147 patients with clinicopathologically proven chronic hepatitis type B through long-term follow-up from the time of the initial biopsy according to histologic classification. 15 patients had chronic persistent hepatitis(CPH). 61 patients had chronic active hepatitis without bridging necrosis(CAH-BN). 46 patients had chronic hepatitis with bridgung necrosis(CAH+BN). 25 patients had chronic active hepatitis with early cirrhotic change(CAH+LC). They were followed for 24 to 150 months(mean 70.8(+25.8)). Results: The probability of developing cirrhosis in chronic hepatitis type B was 0%, 2%, 10%, 18%, 23%, 28%, 37%, 49%, 54% in 1 year to 9 years, respectively. The 5-year cumulative probability of developing cirrhosis was 9% in CPH, 14% in CAH-BN, 22% in CAH+BN, and 55% in CAH+LC. The significant prognostic factors of developing cirrhosis were age(p<0.01) and histologic classification(p<0.001). The probability of developing decompensated cirrhosis in chronic hepatitis type B was 0%, 0%, 0%, 1%, 5%, 13%, 17%, 28%, and 32% in 1 year to 9 years, respectively. The probability of developing hepatocellular carcinoma(HCC) in chronic hepatitis type B was 0%, 0%, 0%, 1%, 3%, 3%, 6%, 8% and 8% in 1 year to 9 years, respectively. The significant prognostic factor of developing HCC was age. Conclusions: The results of this study explored the natural history and prognostic factors of chronic hepatitis type B. 5-year cumulative probability of developing cirrhosis, decompensated cirrhosis and HCC was 23%, 5% and 3%, respectively. Histologic classification and age were significant prognostic factors for the development of cirrhosis. Age was a significant prognostic factor for the development of HCC. (Korean J Gastroenterol 1997;29:343 - 351)
비인강악성종양에서 유도화학요법과 방사선요법을 병행치료한 결과
서장수(Jang Su Suh),김용대(Yong Dae Kim),전재윤(Jae Yun Chun),김준홍(Jun Hong Kim),이정화(Jung Hwa Lee),신세원(Sei Won Shin) 대한두경부종양학회 1994 대한두경부 종양학회지 Vol.10 No.2
The malignant tumor of nasopharynx occurs in china and other oriental contries as high incidence and its prognosis is relatively poor because of frequent intracranial extension and early metastasis. Traditional therapeutic modality of nasopharyngeal cancer was definite radiotherapy, but recently some cancer institute had tried combined modality with induction chemotherapy and reported it may be valuable. We report the clinical evaluation and therapeutic result about 28 nasopharyngeal cancer patients which were treated with 2 courses of induction chemotherapy(Cisplatin+5-FU) and radiotherapy. The results were as follows: 1) The 3 years and 5 years survival rate were 76% and 47% in total patients. 2) The 3 years and 5 years survival rate were 92% and 63% in T1, T2, T3 group, and 25% and 0% in T4 group. 3) The 3 year and 5 year survival rate were 100% and 60% in neck node negative group, and 60% and 40% in neck node positive group. 4) The 3 year and 5 years survival rate were 100% and 50% in stage I II group, and 71% and 44% in stage III, IV group.
강진경(Jin Kyung Kang),최흥재(Heung Jai Choi),박인서(In Suh Park),문영명(Young Myoung Moon),이상인(Sang In Lee),김경희(Kyung Hee Kim),전재윤(Jae Yun Chun) 대한소화기학회 1984 대한소화기학회지 Vol.16 No.1
N/A ERCP were studied in 20 patients with clonorchiasis and 13 patients with ascariasis from July, 1973 to October, 1983. The following results were obtained. 1) In biliary clonorchiasis, the intrahepatic duct was more severely affected than common bile duct and gall bladder. The distinct cholangiographic findings were dilatation, irregular contour, small filling defect and hazy appearance of bile duct. 2) In 12 of 13 patients with ascariasis, adult worms were demonstrated in CBD and in 1 patient, it was in main pancreatic duct. 3) Biliary stones were associated in 7 of 20 patients with clonorchiasis and in 7 of 13 patients with ascariasis. 4) 2 of 13 patients with ascariasis were treated by endoscopic removal of ascaris worm. 5) ERCP seems to be a more accurate way to make diagnosis of biliary parasites. In addition, with the use of newer instrumentation, it may become possible to manually remove ascaris worm via endoscope.