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마그네슘 이온이 적출한 흰쥐 자궁근의 수축성에 미치는 효과
장상호,황상익,성호경,Chang, Sang-Ho,Hwang, Sang-Ik,Sung, Ho-Kyung 대한생리학회 1986 대한생리학회지 Vol.20 No.2
The effects of $Mg^{++}$ upon the spontaneous contraction activated by 1 IU/l oxytocin were studied in the isolated rat uterine muscle. Longitudinal muscle strips u·ere prepared from the rat uteri at the estrous stage. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100% $O_2$ and kept at $35^{\circ}C$. The results obtained were as follows: 1) In the uterine strips contracting spontaneously, as $Mg^{++}$ concentration increased in the Tyrode solution the amplitude of peak tension decreased in all the experimental solutions containing the various concentrations of $Ca^{++}\;(0.5{\sim}4 mM)$. And the amplitude of peak tension increased in inverse proportion to the $[Mg^{++}]/[Ca^{++}]\; ratio$. It is suggested that the tension-lowering effect of $Mg^{++}$ would be developed through decreasing intracellular ionized free calcium ion concentration by uncertain mechanism. 2) The frequency of the uterine contraction activated by oxytocin increased as the $[Mg^{++}]/[Ca^{++}]\;ratio$ ratio increased up to 1/2, but the frequency decreased above this ratio. It is speculated that $Mg^{++}$ would influence the excitability control action of $Ca^{++}$.
만성폐질환에서 haemophilus influenzae 의 분리 및 약제 감수성에 관한 연구
김성규(Sung Kyu Kim),조철호(Chul Ho Cho),장상호(Sang Ho Jang),장준(Joon Chang),임명기(Myung Gi Lim),이원영(Won Young Lee),정윤섭(Jun Sop Chong) 대한내과학회 1990 대한내과학회지 Vol.39 No.3
N/A Hemophilus influenzae is being recognized with increasing frequenzy in various literature as a cause of pneumonia and of acute exacerbations of chronic lung disease indluding COPD and bronchiectasis. Currently, however, the incidence of H. influenzae ae a respiratory pathogen in adults is often underestimated in our country, In this study, the prevalence of H. iefluenzae and the antimicrobial resistance rate and efficacy of Cefaclor were assessed among a total of 155 patients with chronic lung diseases during the period from July 198S to June 1989. The following results were obtained: 1) The prevalence of H. influenzae in chronic airway diseases was 16.1% when routine media were used. With selective media, the positive rate was significantly highter (66.5%). 2) Among the 101 strains, 2% were serotype b and 90.1% were non-typable. 3) In the total 98% H. influenzae isolates studied, 18.4%, were resistant to ampicillin and none to Cefaclor and tetracycline, 4) The overall bacterialogical response of H. influenzae to Cefaclor, which is one of the two most active drugs, was found to be as follows: Eliminated 60.0%, Reduced markedly 22.9%, Persistent 11.4% and lncreased 5.7%, However, the results of Persistent and Increased could be found in selective media only. This study revealed the relatively high prevalence of H. influenzae in patients with Chronic airway diseases. The prevalence of H. influenzae was significantly higher when selective media was used for culture.
원저 : 흉막삼출 원인질환의 감별진단에 있어서 흉막액 Adenosine Deaminase 활성도 및 Carcinoembryonic Antigen 병행측정의 임상적 의의
이장훈 ( Jang Hoon Lee ),장상호 ( Sang Ho Jang ),이홍렬 ( Hong Lyeol Lee ),곽승민 ( Seung Min Kwak ),장중현 ( Jung Hyun Chang ),김병일 ( Byung Il Kim ),천선희 ( Sun Hee Cheon ),김세규 ( Se Kyu Kim ),장준 ( Joong Chang ),김성규 ( 대한결핵 및 호흡기학회 1993 Tuberculosis and Respiratory Diseases Vol.40 No.1
원저 : 폐결핵 환자의 기관지폐포세척액에서 Adenosine Deaminase 활성도에 관한 연구
천선희 ( Seon Hee Cheon ),조철호 ( Chul Ho Cho ),김병일 ( Byung Il Kim ),장상호 ( Sang Ho Jang ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),한지숙 ( Jee Sook Hahn ),이원영 ( Won Young Lee ),권오헌 ( Oh Hun Kwon ) 대한결핵 및 호흡기학회 1991 Tuberculosis and Respiratory Diseases Vol.38 No.1
백서 폐동맥 내피세포에서 cytokine 및 내독소에 의한 nitric oxide 생성과 미토콘드리아 aconitase 활성도의 관계
김세규(Se Kyu Kim),장준(Joon Chang),이원영(Won Young Lee),장상호(Sang Ho Jang),박전한(Jeon Han Park),김세종(Se Jong Kim),김성규(Sung Kyu Kim),(Boaz A . Markewitz),(John R . Michael) 대한내과학회 1999 대한내과학회지 Vol.56 No.2
N/A Objective : Both constitutive and inducible forms of nitric oxide synthase exist in endothelial cells. Disorders that produce acute lung injury frequently release endotoxin and cytoknes, such as interferon(IFNγ) and tumor necrosis factor (TNFα). Endotoxin and these cytokines likely act as important mediators of cell injury. Because nitric oxide (NO) avidly reacts with iron, it may affect the activity of key enzymes, such as mitochondrial aconitase, which contain an iron-sulfur structure as a prosthetic group. Method : We studied the effect of IFNγ, TNFα and E. coli lipopolysaccharide(LPS) on NO production and mitochondrial aconitase activity in cultured rat lung microvascular endothelial cells(RLMVC). Result : Exposing RLMVC for 24 hours to IFNγ(500 U/mL), TNFα(300 U/mL) and LPS(5 ㎍/mL) significantly increases nitrite production to 20±1 μM compared to 0.07 μM in control cells(P<0.05, n=4). Cytokine treatment also reduced mitochondrial aconitase activity from 196±8 to 102±34 nmole/min/mg of cell protein(P<0.05, n=4). Treatment with the inhibitor of nitric oxide synthase N-monomethyl-L-arginine(NMMA) (0.5 mM) not only significantly blunted the cytokine- mediated increase in nitrite formation (3±0.5 μM vs 20±1 μM with cytokines, P<0.05, n=4), but also prevented the cytokine-mediated drop in aconitase activity (161± 24 vs. 196±8 nmole/min/mg of cell protein, NS). Conclusion : Exposing RLMVC to IFNγ, TNFα and E. coli LPS substantially decreases mitochondrial aconitase activity. Nitric oxide appears to mediate this effect. Our results suggest that the excessive production of NO by endothelial cells, in response to cytokines and endotoxin, may inhibit the function of the endothelial cell itself.
경미한 호흡기질환 환자에서 정상 및 건축 폐에서의 기관지폐포 세척액내 세포 분포에 관한 연구
김병일 ( Byung Il Kim ),조철호 ( Chul Ho Cho ),강신욱 ( Shin Wook Kang ),천선희 ( Seon Hee Heon ),장상호 ( Sang Ho Jang ),이장훈 ( Jang Hoon Lee ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ) 대한결핵 및 호흡기학회 1991 Tuberculosis and Respiratory Diseases Vol.38 No.2