수종의 치근형 골내매식체와 조직간의 반응에 관한 조직학적 연구

이호영,김영수,Lee, Ho-Young,Kim, Yung-Soo 대한치과보철학회 1990 대한치과보철학회지 Vol.28 No.1

The success or failure of endosseous dental implants is related to the cellular activity at the implant surface. Success seems to be associated with the enclosure of the implant in a non-inflammed connective tissue or the formation of a direct bone implant interface. The purpose of this study was to examine the tissue reactions to the various implants at the submergible state in dog mandible. The $Br\"{a}nemark$, Core-Vent, Intergral, Bone spiral were selected for evaluation and also the Kimplant, Nephrite were used for the experimental study. After 4 months the animals were sacrificed. The interface zone between bone and implant was investigated using x-rays, light microscope, scanning electron microscope, transmission electron microscope. The following results were obtained from this study. 1. $Br\"{a}nemark$, Core-Vent, Kimplant, Integral showed no mobility and bone growth over the healing screws of the implants. Histologically most of the implant surface were covered by remodelled lamellar bone, and partly by a cellular layer or the thin fibrous tissue layer. 2. The Bone spiral showed no mobility and partially radiolucent line around the implant. The upper part of the implant was surrounded by a thin fibrous connective tissue and the middle, apical part of it were contacted with bone directly. 3. The Nephrite implant showed severe mobility and a radiolucent line around the implant. Histologically it showed mild inflammation and was surrounded by a fibrous connective tissue. 4. Scanning electron microscope showed that there was no amorphous ground substance in the Nephrite implant but the formation of ground substance over the collagen filaments in other implants. 5. Transmission electron microscope showed that collagen filaments were approached irregularly to the surface of all implants and in the $Br\"{a}nemark$, Core-Vent, Kimplant, Integral there was amorphous layer between the implant and the collagen filaments. It seemed to be ground substances.

신증후군 환자에서 발생한 혈전증의 임상적 고찰

이호영(Ho Yung Lee),한승희(Seung Hee Han),정현철(Hyun Cheol Chung),황성철(Sung Chul Hwang),이영식(Young Sik Lee),조준구(Jun Koo Cho),한대석(Dae Suk Han) 대한내과학회 1988 대한내과학회지 Vol.34 No.2

N/A It is well known that thromboembolic complication can develop in patients with nephrotic syndrome. The precise mechanism for this complication is not clear yet, but several clotting disorders may be operable in combination to induce the hypercoagulable state espicially in nephrotic syndrome with predisposing factors. The authors reviewed 474 patients with nephrotic syndrome who admitted to Severance Hosipal from January 1980 to April 1987 and the following results were obtained. 1) The incidence of thromboembolism in patients with nephrotic syndrome was 3% with 14 cases among 474 cases of nephrotic syndrome. This complication developed most commonly in patients with membranous nephropathy with 13% among 46 cases. 2) Venous thrombosis were noted in 12 cases and aterial thrombosis in 2 cases of all 14 cases of these complications. Renal vein thrombosis was the most common type with 6 cases (43%). 3) The demonstrable precipitating conditions to this thromboembolic complication were membranous nephropathy in 6 cases (43%) and long-term use of diuretics in 4 cases (28.8%). 4) The clotting tests revealed increased fibrinogen level and decreased antithrombin III, but platelet counts, prothrombin time and partial thromboplastin time were within normal limits. 5) Almost all patients with this complication improved considerably with conservative treatment including anticoagulants but amputation in a patient with arterial thrombosis and nephrectomy in a patient with extensive renal vein thrombosis were needed and a patient died of massive pulmonary thromboembolism. In conclusion, although the incidence of acute massive thromboembolism is not so high in nephrotic syndrome it is necessary to give a full attention to detect this complication at early stage for the reduction of morbidity and mortality in the patients with nephrotic syndrome.

Gentamicin 과 Tobramycin 의 Nephrotoxicity 에 관한 비교 연구

이호영 ( Ho Yung Lee ),박양생 ( Yang Saeng Park ) 대한내과학회 1985 대한내과학회지 Vol.29 No.2

장기 투석치료 환자에서 투석유형별 임상지표에 관한 비교연구

이호영(Ho Yung Lee),함영환(Young Hwan Ham),윤여운(Yoe Wun Yoon),김형길(Hyung Kil Kim),정동균(Dong Kyoon Chung),최규헌(Kyu Hun Choi),한대석(Dae Suk Han) 대한내과학회 1989 대한내과학회지 Vol.36 No.2

N/A We investingated 71 cases with ESRD who had undergone CAPD or hemodialysis for more than 2 years without diabetic nephropathy, and the following results were obtained: 1. The mean age and male to female ratio for the patients in the hemodialysis group (n:38) were 50 and 2.8;1, respectively. The mean age of the CAPD group (n:33) was 43 and the male to female reatio was 1,2:l. The mean duration of dialysis in hemodialysis and CAPD was 3.6 and 2.9 years, respectively. 2. Hypertension and anemia associated with ESRD were more easily controlled in the CAPD patients than in the hemodialysis group. So, after 3 months of dialysis, both the systolic and diastolic blood pressures were lower in the CAPD group(p<0.05) The average value of annual transfusion requirements in hemodialysis patients was 1.9 pints and that in CAPD patients was 0.35 pints. 3. Values of BUN, serum potassium and CO, content were more stable in the CAPD group as compared to hemodialysis patients after 3 months of dialysis, However, serum cholesterol, triglyseride and HDL - cholesterol values were significantly higher in the CAPD group than in hemodialysis patients(p<0.05), 4 The number of days spent in the hosjpital during dialysis was longer in the CAPD group, probably due to peritonitis The annual duration of hospitalization per patient in the CAPD group was 6.3 days as compared to 1.9 days in hemodialysis patients, 5 The quality of life of the CAPD group, as assessed by the physical performance status, was superior to that of the hemodialysis group Based on these results, although CAPD still has the unsolved problems of a longer duration of hospitalization and hyperlipidemia, it seemed to have many advantages in controlling hypertension, electrolyte imbalance, acidosis and anemia Therefore it could be employed as a primary mode of treatment in ESRD patients, especially in Korea with shortage of hemodialyeis machines.

The Role of Cyclosporine A in the Treatment of Nephrotic Syndrome

이호영(Ho Yung Lee) 대한신장학회 2000 춘계학술대회 초록집 Vol.2000 No.-

N/A

지속성 외래 복막투석 환자에서 갑상선기능의 변화

이호영 ( Ho Yung Lee ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.1

Background : In peritoneal dialysis patients, altered thyroid function was reported but the frequncy and pathophysiology were not well understood. The object of this study is to evaluate the effect of continuous ambulatory peritoneal dialysis (CAPD) on thyroid function by observing the frequency of primary thyroid dysfunction and the sequential change of thyroid function after CAPD. Methods : In a cross-sectional study, thyroid function test (TFT) was don for 192 CAPD patients between Jan. 2001 and Jan. 2002. For another 38 CAPD patients, we observed sequential change of thyroid function by performing TFT before and 6, 12, 24 months after 200 mL sample of 24-hour dialysate effluent was lyophilized. TFTs were interpreted as subclinical hypothyroidism (shhypo) when TSH is over 5 uIu/mL, mild hypothyroidism (mhypo) when TSH is between 5 and 10 uIu/mL with decreased fT4, and overt hypothyroidism (ohypo) when TSH level is over 10 uIu/mL with decreased fT4. Results : Frequencies of normal thyroid function sbhypo. mhypo and ohypo were 81.2%, 11%, 5.2%, and 2.6% respectively. Serum levels of TSH before and 6, 12, 24 months after CAPD were 2.6±0.1, 3.8±0.3, 4.2±0.5, 4.1±0.5 uIu/mL respectively and the frequencies of thyroid dysfunction including subclinical hypothyroidism were 6.4, 23.6, 26.3, 28.8% respectively, which showed the increasing tendency. Peritoneal loss of TSH was 11,067±1,776 uIu/day, and that of TT4 was 11.68±2.7 ㎍/day. These were approximately 7%, and 10% of daily production rate. Conclusion : TSH increased after start of CAPD and thyroid dysfunction including subclinical hypothyoidism wea observed in significant proportion of CAPD patients. Thyroid hormones were eliminated by peritoneal dialysis. It can be suggested that CAPD affects thyroid function. Clinical significance of the above observation needs further well-controlled study.

지속성 외래 복막투석 환자에서 복막염의 위험인자에 관한 연구

이호영(Ho Yung Lee),김영수(Young Soo Kim),김영기(Young Ki Kim),김흥수(Heung Soo Kim),손승환(Seung Hwan Sohn),최규헌(Kyu Hun Choi),한대석(Dae Suk Han) 대한내과학회 1991 대한내과학회지 Vol.40 No.6

N/A Continuous ambulatory peritoneal dialysis (CAPD) has many advantages over hemodialysis, but it has certain inherent difficulties and is will known for its failure due to peritonitis. The authors studied CAPD patients of Yonsei University, College of Medicine, Severance Hospital, who were receiving CAPD up to September 1, 1990. They were individually studied for relative risk of possible risk factors, which are sex, age, place of domicile, status of marriage, motivation, educational level, economic status, employment status, sterile technique in exchanging a fluid bag, place of exchanging a fluid bag, CAPD duration, type of dialysate, diabetes, hypertension, hyperlipidemia, exit site infection, BUN, serum creatinine, and HBs Ag. The follow-up study traced the frequency of peritonitis in a total of 237 subjects. It was possible to study 127 patients who were subjected to a questionnaire and nutritional score system and who were receiving at least 6 months of CAPD. Through this study, material on the annual incidence of peritonitis, the interval between the insertion of CAPD and onset of the first peritonitis, the interval between the onset of the first and second peritonitis, and the risk factors which influenced the above subjects were obtained. The results obtained were as follows: 1) The number of patients comprised 53 men and 74 women, and the age distribution was between 17 and 80 years with a mean of 45.8 years. The mean duration of CAPD was 28.7 months with a range between 6.1 and 80.4 months. 2) The incidence ot peritonitis was higher in patients with poor nutritional status, no employment, and low education level according to univariate analysis (p<0.05). The results of the multiple regression model showed that the significant risk factors affecting the incidence of peritonitis were nutritional status, employment status, and place of domicile (relative risk<0.5 or >1.5). 3) The interval between the insertion of CAPD and the onset of the first peritonitis was shorter in poor nuteritional patients according to univariate analysis. In subjects who were unemployed, had diabetes mellitus, and who were women, the interval between the onset of the first and second peritonitis was shorter according to the Cox regression model (p<0.05). 4) The results of the Cox hazard regression model showed that the interval between the onset of the first and second peritonitis was shorter in patients without employment, with diabetes mellitus, and those living in rural areas (relative risk<0.5 or >1.5). From the above results, it can be seen that the risk factors significantly affecting the incidence of peritonitis were nutritional status, employment status. type of dialysate, and place of domicile. Significant risk factors affecting the interval before the onset of the first peritonitis were not found, but the interval from the first to the second pertionitis was affected by significant risk factors such as diabetes mellitus, employment status, and place of domicile. In conclusion, the maintenance of nutrition up to the level of normal physical activity can reduce the incidence of peritonitis in patients with CAPD.

Aminoglycoside 항생제에 의하여 유발되는 신장장애 기전에 관한 연구

이호영 ( Ho Yung Lee ),박양생 ( Yang Saeng Park ) 대한내과학회 1985 대한내과학회지 Vol.29 No.4

논문 : 시장 세분화와 모형 결합을 활용한 효과적인 생명보험 고객이탈예측모형에 관한 연구

이호영 ( Ho Yung Lee ),김성재 ( Sung Jae Kim ),이훈영 ( Hoon Young Lee ) 한국보험학회 2006 保險學會誌 Vol.74 No.-

신장이식후 발병하는 당뇨병의 특성에 관한 연구

김유리(Yoo Lee Kim),조용욱(Yong Wook Cho),이관우(Kwan Woo Lee),김한수(Han Soo Kim),임승길(Sung Kil Lim),이현철(Hyun Chul Lee),허갑범(Kap Bum Huh),이호영(Ho Yung Lee),한대석(Dae Suk Han),김유선(Yu Seun Kim),박기일(Ki Il Park) 대한내과학회 1989 대한내과학회지 Vol.37 No.2

N/A To investigate the etiopathogenic factors in the development of posttransplant diabetes, we reiviewed 163 kidney transplant patients among whom 16 patients developed diabetes after transplantation. The results were of follows: 1) Patients who developed posttransplant diabetes were 16 cases (9.8%). 2) Patients whose fasting blood sugar levels were more than 121mg% and less than 140mg% before transplantation were 35 cases (21.4%) and the prevalence of posttransplant diabetes (22.8%) in this group was higher than that (6.2%) in patients whose fasting blood sugar levels were less than 121mg% before transplantation. 3) Posttransplant diabetic patients, usually under-weight and in a nutritionally deprived state, developed diabetes in a relatively short period after transplantation with high blood sugar levels while some patients devleoped diabetes more than 1 year after transplantation with marked weight gain. 4) The mean age of patients at transplantation and the phenotype frequency of HLA-B15 antigen were higher in patients who developed posttransplant diabetes than in patients who did not, but there was no difference in the number of rejection episodes and kinds of immunsuppressants. It might be suggested that the preperative state of glucose tolerance associated with the nutritional state of patients receiving kidney transplantation could have a permissive role when various factors interact in the development of posttransplant diabetes.